CCSA_PROMM
ID CCSA_PROMM Reviewed; 318 AA.
AC Q7V806;
DT 04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Cytochrome c biogenesis protein CcsA {ECO:0000255|HAMAP-Rule:MF_01391};
GN Name=ccsA {ECO:0000255|HAMAP-Rule:MF_01391}; OrderedLocusNames=PMT_0570;
OS Prochlorococcus marinus (strain MIT 9313).
OC Bacteria; Cyanobacteria; Synechococcales; Prochlorococcaceae;
OC Prochlorococcus.
OX NCBI_TaxID=74547;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MIT 9313;
RX PubMed=12917642; DOI=10.1038/nature01947;
RA Rocap G., Larimer F.W., Lamerdin J.E., Malfatti S., Chain P., Ahlgren N.A.,
RA Arellano A., Coleman M., Hauser L., Hess W.R., Johnson Z.I., Land M.L.,
RA Lindell D., Post A.F., Regala W., Shah M., Shaw S.L., Steglich C.,
RA Sullivan M.B., Ting C.S., Tolonen A., Webb E.A., Zinser E.R.,
RA Chisholm S.W.;
RT "Genome divergence in two Prochlorococcus ecotypes reflects oceanic niche
RT differentiation.";
RL Nature 424:1042-1047(2003).
CC -!- FUNCTION: Required during biogenesis of c-type cytochromes (cytochrome
CC c6 and cytochrome f) at the step of heme attachment.
CC {ECO:0000255|HAMAP-Rule:MF_01391}.
CC -!- SUBUNIT: May interact with ccs1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cellular thylakoid membrane {ECO:0000255|HAMAP-
CC Rule:MF_01391}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01391}.
CC -!- SIMILARITY: Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.
CC {ECO:0000255|HAMAP-Rule:MF_01391}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX548175; CAE20745.1; -; Genomic_DNA.
DR RefSeq; WP_011129949.1; NC_005071.1.
DR AlphaFoldDB; Q7V806; -.
DR SMR; Q7V806; -.
DR STRING; 74547.PMT_0570; -.
DR EnsemblBacteria; CAE20745; CAE20745; PMT_0570.
DR KEGG; pmt:PMT_0570; -.
DR eggNOG; COG0755; Bacteria.
DR HOGENOM; CLU_049710_2_4_3; -.
DR OMA; WLVMHVS; -.
DR OrthoDB; 955123at2; -.
DR Proteomes; UP000001423; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031676; C:plasma membrane-derived thylakoid membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0015232; F:heme transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0017004; P:cytochrome complex assembly; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01391; CytC_CcsA; 1.
DR InterPro; IPR002541; Cyt_c_assembly.
DR InterPro; IPR003557; Cyt_c_biogenesis_CcmC.
DR InterPro; IPR017562; Cyt_c_biogenesis_CcsA.
DR InterPro; IPR045062; Cyt_c_biogenesis_CcsA/CcmC.
DR PANTHER; PTHR30071; PTHR30071; 1.
DR Pfam; PF01578; Cytochrom_C_asm; 1.
DR PRINTS; PR01386; CCMCBIOGNSIS.
DR TIGRFAMs; TIGR03144; cytochr_II_ccsB; 1.
PE 3: Inferred from homology;
KW Cytochrome c-type biogenesis; Membrane; Reference proteome; Thylakoid;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..318
FT /note="Cytochrome c biogenesis protein CcsA"
FT /id="PRO_5000096686"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01391"
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01391"
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01391"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01391"
FT TRANSMEM 149..169
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01391"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01391"
FT TRANSMEM 258..275
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01391"
FT TRANSMEM 287..307
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01391"
SQ SEQUENCE 318 AA; 34376 MW; 260C28BD267A602D CRC64;
MFGVTLAELS ASLGDPVLAL GLAAFALLLL AIPISFWMVS GGSNSAVVTL LVALANLVLT
AQLVLRWWQS GHFPISNLYE SLCFLAWACT LAQLLVERSL SSPIVSAAAT PMALLCVAFA
SFALPETLQE ASPLVPALRS SWLVMHVSVI MCSYAALLVG SFLSMAVLFT DRQQTLELRS
SSIGTGGFRQ AKLATSSMDQ SDGLRLSSIN LSRTEQLDSL SYRTITVGFL LLTLGLISGA
VWANEAWGSW WSWDPKETWA LICWMVYAAY LHTRFSRGWS GRRPALVAVA GIVVIVVCYI
GVNLLGIGLH SYGWFFEA