CCSDS_ARATH
ID CCSDS_ARATH Reviewed; 578 AA.
AC Q1PFW3; Q8RYC7; Q9LQV6;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-MAY-2007, sequence version 2.
DT 25-MAY-2022, entry version 105.
DE RecName: Full=Cyclin-SDS;
DE AltName: Full=Protein SOLO DANCERS;
GN Name=SDS; OrderedLocusNames=At1g14750; ORFNames=F10B6.15;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, DEVELOPMENTAL STAGE,
RP INTERACTION WITH CDKA-1 AND CDKB1-1, AND DISRUPTION PHENOTYPE.
RX PubMed=12065421; DOI=10.1093/emboj/cdf285;
RA Azumi Y., Liu D., Zhao D., Li W., Wang G., Hu Y., Ma H.;
RT "Homolog interaction during meiotic prophase I in Arabidopsis requires the
RT SOLO DANCERS gene encoding a novel cyclin-like protein.";
RL EMBO J. 21:3081-3095(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15208425; DOI=10.1104/pp.104.040436;
RA Wang G., Kong H., Sun Y., Zhang X., Zhang W., Altman N., dePamphilis C.W.,
RA Ma H.;
RT "Genome-wide analysis of the cyclin family in Arabidopsis and comparative
RT phylogenetic analysis of plant cyclin-like proteins.";
RL Plant Physiol. 135:1084-1099(2004).
CC -!- FUNCTION: Meiosis-specific cyclin. Required for normal homolog synapsis
CC and recombination in early to mid-prophase 1. May regulate the timing
CC of sister chromatid separation. {ECO:0000269|PubMed:12065421}.
CC -!- SUBUNIT: May interact with CDKA-1 AND CDKB1-1.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q1PFW3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q1PFW3-2; Sequence=VSP_025289;
CC -!- DEVELOPMENTAL STAGE: Expressed during male meiosis specifically in male
CC meiotic cells (male meiocytes within anther locules). Expressed during
CC female meiosis specifically in the female meiocytes within the ovule.
CC {ECO:0000269|PubMed:12065421}.
CC -!- DISRUPTION PHENOTYPE: Plants exhibit a severe defect in homolog
CC synapsis recombination and bivalent formation in prophase 1, resulting
CC in random chromosome distribution and formation of abnormal meiotic
CC products. {ECO:0000269|PubMed:12065421}.
CC -!- SIMILARITY: Belongs to the cyclin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF79244.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AJ457977; CAD30003.1; -; mRNA.
DR EMBL; AC006917; AAF79244.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE29217.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE29218.1; -; Genomic_DNA.
DR EMBL; DQ446250; ABE65620.1; -; mRNA.
DR RefSeq; NP_001077539.1; NM_001084070.2. [Q1PFW3-2]
DR RefSeq; NP_172928.2; NM_101344.3. [Q1PFW3-1]
DR AlphaFoldDB; Q1PFW3; -.
DR SMR; Q1PFW3; -.
DR IntAct; Q1PFW3; 2.
DR STRING; 3702.AT1G14750.1; -.
DR PaxDb; Q1PFW3; -.
DR EnsemblPlants; AT1G14750.1; AT1G14750.1; AT1G14750. [Q1PFW3-1]
DR EnsemblPlants; AT1G14750.2; AT1G14750.2; AT1G14750. [Q1PFW3-2]
DR GeneID; 838040; -.
DR Gramene; AT1G14750.1; AT1G14750.1; AT1G14750. [Q1PFW3-1]
DR Gramene; AT1G14750.2; AT1G14750.2; AT1G14750. [Q1PFW3-2]
DR KEGG; ath:AT1G14750; -.
DR Araport; AT1G14750; -.
DR TAIR; locus:2006827; AT1G14750.
DR eggNOG; KOG0653; Eukaryota.
DR InParanoid; Q1PFW3; -.
DR OMA; CSEMELQ; -.
DR PhylomeDB; Q1PFW3; -.
DR PRO; PR:Q1PFW3; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q1PFW3; baseline and differential.
DR Genevisible; Q1PFW3; AT.
DR GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0051026; P:chiasma assembly; IMP:TAIR.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IMP:TAIR.
DR GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central.
DR GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IBA:GO_Central.
DR CDD; cd00043; CYCLIN; 2.
DR InterPro; IPR039361; Cyclin.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR004367; Cyclin_C-dom.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10177; PTHR10177; 2.
DR Pfam; PF02984; Cyclin_C; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SUPFAM; SSF47954; SSF47954; 2.
DR PROSITE; PS00292; CYCLINS; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell cycle; Cell division; Cyclin; Meiosis;
KW Reference proteome.
FT CHAIN 1..578
FT /note="Cyclin-SDS"
FT /id="PRO_0000287062"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 90..257
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17147637"
FT /id="VSP_025289"
SQ SEQUENCE 578 AA; 65201 MW; 545EA75BD084DADD CRC64;
MKEIAMRNSK RKPEPTPFAG KKLRSTRLRR KRAQISPVLV QSPLWSKQIG VSAASVDSCS
DLLADDNVSC GSSRVEKSSN PKKTLIEEVE VSKPGYNVKE TIGDSKFRRI TRSYSKLHKE
KEGDEIEVSE SSCVDSNSGA GLRRLNVKGN KINDNDEISF SRSDVTFAGH VSNSRSLNFE
SENKESDVVS VISGVEYCSK FGSVTGGADN EEIEISKPSS FVEADSSLGS AKELKPELEI
VGCVSDLACS EKFSEEVSDS LDDESSEQRS EIYSQYSDFD YSDYTPSIFF DSGSEFSEKS
SSDSPISHSR SLYLQFKEQF CRSTIPNDFG SSCEEEIHSE LLRFDDEEVE ESYLRLRERE
RSHAYMRDCA KAYCSRMDNT GLIPRLRSIM VQWIVKQCSD MGLQQETLFL GVGLLDRFLS
KGSFKSERTL ILVGIASLTL ATRIEENQPY NSIRKRNFTI QNLRYSRHEV VAMEWLVQEV
LNFKCFTPTI FNFLWFYLKA ARANPEVERK AKSLAVTSLS DQTQLCFWPS TVAAALVVLA
CIEHNKISAY QRVIKVHVRT TDNELPECVK SLDWLLGQ
