CCSE1_MOUSE
ID CCSE1_MOUSE Reviewed; 895 AA.
AC Q8C0C4; Q3KN97; Q69ZD5; Q8C822;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 2.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Serine-rich coiled-coil domain-containing protein 1;
DE AltName: Full=Coiled-coil serine-rich protein 1;
GN Name=Ccser1; Synonyms=Fam190a, Kiaa1680;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 513-895 (ISOFORM 3).
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 321-895 (ISOFORM 1).
RC TISSUE=Fetal brain;
RX PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 11:205-218(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8C0C4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8C0C4-2; Sequence=VSP_035320, VSP_035321;
CC Name=3;
CC IsoId=Q8C0C4-3; Sequence=VSP_035322, VSP_035323;
CC -!- SIMILARITY: Belongs to the CCSER family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD32509.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK031754; BAC27537.1; -; mRNA.
DR EMBL; AK048645; BAC33408.1; -; mRNA.
DR EMBL; AC122505; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC103630; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC113320; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC122524; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC125119; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC137119; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC154007; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC154008; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC168089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC174640; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC174778; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC107398; AAI07399.1; -; mRNA.
DR EMBL; BC107399; AAI07400.1; -; mRNA.
DR EMBL; BC117738; AAI17739.1; -; mRNA.
DR EMBL; AK173231; BAD32509.1; ALT_INIT; mRNA.
DR CCDS; CCDS51800.1; -. [Q8C0C4-1]
DR RefSeq; NP_001157788.1; NM_001164316.1. [Q8C0C4-1]
DR RefSeq; NP_899133.2; NM_183310.2. [Q8C0C4-1]
DR RefSeq; XP_006506017.1; XM_006505954.1. [Q8C0C4-3]
DR AlphaFoldDB; Q8C0C4; -.
DR SMR; Q8C0C4; -.
DR STRING; 10090.ENSMUSP00000122894; -.
DR iPTMnet; Q8C0C4; -.
DR PhosphoSitePlus; Q8C0C4; -.
DR PaxDb; Q8C0C4; -.
DR PRIDE; Q8C0C4; -.
DR ProteomicsDB; 279953; -. [Q8C0C4-1]
DR ProteomicsDB; 279954; -. [Q8C0C4-2]
DR ProteomicsDB; 279955; -. [Q8C0C4-3]
DR Antibodypedia; 44922; 85 antibodies from 17 providers.
DR Ensembl; ENSMUST00000045522; ENSMUSP00000040251; ENSMUSG00000039578. [Q8C0C4-1]
DR Ensembl; ENSMUST00000126214; ENSMUSP00000122894; ENSMUSG00000039578. [Q8C0C4-1]
DR GeneID; 232035; -.
DR KEGG; mmu:232035; -.
DR UCSC; uc009cdu.2; mouse. [Q8C0C4-2]
DR UCSC; uc009cdw.2; mouse. [Q8C0C4-1]
DR CTD; 401145; -.
DR MGI; MGI:3045354; Ccser1.
DR VEuPathDB; HostDB:ENSMUSG00000039578; -.
DR eggNOG; ENOG502QXW4; Eukaryota.
DR GeneTree; ENSGT00940000153912; -.
DR HOGENOM; CLU_011774_0_0_1; -.
DR InParanoid; Q8C0C4; -.
DR OMA; TDWPLQG; -.
DR OrthoDB; 308075at2759; -.
DR PhylomeDB; Q8C0C4; -.
DR TreeFam; TF331021; -.
DR BioGRID-ORCS; 232035; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Ccser1; mouse.
DR PRO; PR:Q8C0C4; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q8C0C4; protein.
DR Bgee; ENSMUSG00000039578; Expressed in animal zygote and 195 other tissues.
DR ExpressionAtlas; Q8C0C4; baseline and differential.
DR Genevisible; Q8C0C4; MM.
DR InterPro; IPR029627; CCSER.
DR InterPro; IPR029628; CCSER1.
DR PANTHER; PTHR22461; PTHR22461; 1.
DR PANTHER; PTHR22461:SF1; PTHR22461:SF1; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..895
FT /note="Serine-rich coiled-coil domain-containing protein 1"
FT /id="PRO_0000349293"
FT REGION 1..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 154..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 332..394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 459..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 731..754
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 675..705
FT /evidence="ECO:0000255"
FT COMPBIAS 27..62
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..142
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..174
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 440..485
FT /note="VLASSLSPYREGRYIERRLRSSSEGTAGSSRMVLKPKDGHVEASSL -> GM
FT QIFLVQKLCTLIFILFEQLFLRHIVNERHVSFVFIISVKSLLWF (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_035320"
FT VAR_SEQ 486..895
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_035321"
FT VAR_SEQ 721..743
FT /note="GLSLKRLEAVQGGRETTHRNRTM -> TNLKHLGAFRRIIPGINGIPNSY
FT (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_035322"
FT VAR_SEQ 744..895
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_035323"
FT CONFLICT 432
FT /note="G -> R (in Ref. 1; BAC27537)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 895 AA; 98217 MW; F630C3EB4233E4A9 CRC64;
MGDSGSRRCT LVSRLPIFRK SINRRHDSLP SSPSSSNTAG VHSSSPSSTN SSSGSTGKRR
SIFRAPSISF HHKKGSEPKP EPTEQNLSIS NGAQPSHSNM QKLSLEEHVK TRGRHSVGFS
SSRSKKITRS LTEDFEREKE PSTNKNVFIN CLSSGRSEGD DSGFTEEQSR RSIKQSTKKL
LPKSFSSHYK FCKSVPQSQS TSLIQQPEFS LAIAQYQEQE AALGRPSPSC SVDVTERAGS
SLQSPLLSAD LTTAQTPSEF LALTEDSLSE ADAFPKSGST ASHCDNFGHN DATSQPTSSL
TAVSKTKMEF VGTAPCVMSP GRYRLEGRCS TELHSSPETP AGNRREVSLQ STELSVGNGS
DPETHLPAHH QRGESPLAHA GEPALRTGSP RTLGSYDQHK ALAERFKGVH PVSDSRVIPS
SGDHVFNKTS YGYEASAAKV LASSLSPYRE GRYIERRLRS SSEGTAGSSR MVLKPKDGHV
EASSLRKHRT GSSSSKMNSL DVLNHLGSCE LDEDDLMLDL EFLEEQNLQP PVCREDSCHS
VMSCTAVLLS PVDPGKEVNM LEEPKCPEPS KQNLSLRITK DTDQEARCSH VSCMPNSPSA
DWPQQGVEEN GGIDSLPFRL MLQECTAVKT LLLKMKRVLQ ESDVSPSSST TSLPISPLTE
EPLPFKDITR DECSMLRLQL KDRDELISQL QAELEKVQHL QKAFASRVDK STQTELLGCD
GLSLKRLEAV QGGRETTHRN RTMSQSHSTR DRKAIHTPTE DRFRYSTADQ TSPYKNICQL
PGLCLSNFLK DKELGGVMKH TRGNHEAVTS EMTQNSRTTM GQSFLKAAAK PEGLPMFSEK
PKDPAALSRQ HSTFTGRFGQ PPRGPISLHT YSRKNVFLHH NLHTTEFQTL GQQDG
