CCT13_ARATH
ID CCT13_ARATH Reviewed; 317 AA.
AC Q8LBC0; Q9SFZ4; Q9SFZ5; Q9SXC3;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Cyclin-T1-3;
DE Short=CycT1;3;
GN Name=CYCT1-3; Synonyms=CYCT; OrderedLocusNames=At1g27630;
GN ORFNames=T17H3.12, T22C5.7, T22C5.8;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP TISSUE SPECIFICITY, AND INTERACTION WITH CDKC-1 AND CDKC-2.
RX PubMed=12678503; DOI=10.1007/s000180300033;
RA Barroco R.M., de Veylder L., Magyar Z., Engler G., Inze D., Mironov V.;
RT "Novel complexes of cyclin-dependent kinases and a cyclin-like protein from
RT Arabidopsis thaliana with a function unrelated to cell division.";
RL Cell. Mol. Life Sci. 60:401-412(2003).
RN [8]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15208425; DOI=10.1104/pp.104.040436;
RA Wang G., Kong H., Sun Y., Zhang X., Zhang W., Altman N., dePamphilis C.W.,
RA Ma H.;
RT "Genome-wide analysis of the cyclin family in Arabidopsis and comparative
RT phylogenetic analysis of plant cyclin-like proteins.";
RL Plant Physiol. 135:1084-1099(2004).
CC -!- SUBUNIT: Interacts with CDKC-1 and CDKC-2.
CC {ECO:0000269|PubMed:12678503}.
CC -!- INTERACTION:
CC Q8LBC0; Q9LFT8: CDKC-1; NbExp=4; IntAct=EBI-2025764, EBI-2025736;
CC Q8LBC0; Q8W4P1: CDKC-2; NbExp=2; IntAct=EBI-2025764, EBI-2025894;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8LBC0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8LBC0-2; Sequence=VSP_025286;
CC -!- TISSUE SPECIFICITY: Abundantly expressed in flowers. Expressed in
CC roots, seedlings, rosettes and stems. {ECO:0000269|PubMed:12678503}.
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin T subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF24942.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC005916; AAD46000.1; -; Genomic_DNA.
DR EMBL; AC012375; AAF24941.1; -; Genomic_DNA.
DR EMBL; AC012375; AAF24942.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE30856.1; -; Genomic_DNA.
DR EMBL; AK117692; BAC42344.1; -; mRNA.
DR EMBL; AF344323; AAK06874.1; -; mRNA.
DR EMBL; AY062805; AAL32883.1; -; mRNA.
DR EMBL; AY081601; AAM10163.1; -; mRNA.
DR EMBL; AK229729; BAF01567.1; -; mRNA.
DR EMBL; AY087303; AAM67327.1; -; mRNA.
DR PIR; D86401; D86401.
DR RefSeq; NP_001321314.1; NM_001332773.1.
DR RefSeq; NP_001321315.1; NM_001332774.1.
DR RefSeq; NP_001321317.1; NM_001332776.1.
DR RefSeq; NP_001321318.1; NM_001332777.1.
DR RefSeq; NP_174084.1; NM_102528.4. [Q8LBC0-1]
DR AlphaFoldDB; Q8LBC0; -.
DR SMR; Q8LBC0; -.
DR BioGRID; 24890; 2.
DR IntAct; Q8LBC0; 2.
DR STRING; 3702.AT1G27630.1; -.
DR PaxDb; Q8LBC0; -.
DR PRIDE; Q8LBC0; -.
DR EnsemblPlants; AT1G27630.1; AT1G27630.1; AT1G27630. [Q8LBC0-1]
DR GeneID; 839655; -.
DR Gramene; AT1G27630.1; AT1G27630.1; AT1G27630. [Q8LBC0-1]
DR KEGG; ath:AT1G27630; -.
DR Araport; AT1G27630; -.
DR TAIR; locus:2196919; AT1G27630.
DR eggNOG; KOG0834; Eukaryota.
DR HOGENOM; CLU_022000_4_1_1; -.
DR InParanoid; Q8LBC0; -.
DR OMA; FANDGPP; -.
DR OrthoDB; 1437076at2759; -.
DR PhylomeDB; Q8LBC0; -.
DR PRO; PR:Q8LBC0; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q8LBC0; baseline and differential.
DR Genevisible; Q8LBC0; AT.
DR GO; GO:0008024; C:cyclin/CDK positive transcription elongation factor complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; HDA:TAIR.
DR GO; GO:0061575; F:cyclin-dependent protein serine/threonine kinase activator activity; IBA:GO_Central.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0032786; P:positive regulation of DNA-templated transcription, elongation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00043; CYCLIN; 1.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR043198; Cyclin/Ssn8.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10026; PTHR10026; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR SMART; SM00385; CYCLIN; 2.
DR SUPFAM; SSF47954; SSF47954; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell cycle; Cell division; Cyclin;
KW Reference proteome.
FT CHAIN 1..317
FT /note="Cyclin-T1-3"
FT /id="PRO_0000287055"
FT VAR_SEQ 78..317
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14593172, ECO:0000303|Ref.5"
FT /id="VSP_025286"
FT CONFLICT 305
FT /note="S -> G (in Ref. 6; AAM67327)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 317 AA; 36762 MW; 7DFB614BB525A5E7 CRC64;
MGEEHPRKRS RQHFEAEARN VSLFESPQCE TSKWYFSREE IERFSPSRKD GIDLVKESFL
RSSYCTFLQR LGMKLHVSQV TISCAMVMCH RFYMRQSHAK NDWQTIATSS LFLACKAEDE
PCQLSSVVVA SYEIIYEWDP SASIRIHQTE CYHEFKEIIL SGESLLLSTS AFHLDIELPY
KPLAAALNRL NAWPDLATAA WNFVHDWIRT TLCLQYKPHV IATATVHLAA TFQNAKVGSR
RDWWLEFGVT TKLLKEVIQE MCTLIEVDRR RNMPPPPPPP RRELSWAIPA AVKPVHMARA
YPFHSYPLQS YRQAGIW
