CCT1_VARVA
ID CCT1_VARVA Reviewed; 113 AA.
AC E2E4E4;
DT 21-SEP-2011, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 1.
DT 25-MAY-2022, entry version 26.
DE RecName: Full=Cholecystoxin;
DE AltName: Full=Cholecystoxin-Vvar1;
DE Contains:
DE RecName: Full=Cholecystoxin-22;
DE Short=CCK-22;
DE Contains:
DE RecName: Full=Cholecystoxin-8;
DE Short=CCK-8;
DE Flags: Precursor;
OS Varanus varius (Lace monitor).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Anguimorpha; Paleoanguimorpha; Varanoidea; Varanidae; Varanus.
OX NCBI_TaxID=8559;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SYNTHESIS OF 80-101 AND 94-101, AND FUNCTION.
RC TISSUE=Venom gland;
RX PubMed=20631207; DOI=10.1074/mcp.m110.001370;
RA Fry B.G., Winter K., Norman J.A., Roelants K., Nabuurs R.J., van Osch M.J.,
RA Teeuwisse W.M., van der Weerd L., McNaughtan J.E., Kwok H.F., Scheib H.,
RA Greisman L., Kochva E., Miller L.J., Gao F., Karas J., Scanlon D., Lin F.,
RA Kuruppu S., Shaw C., Wong L., Hodgson W.C.;
RT "Functional and structural diversification of the Anguimorpha lizard venom
RT system.";
RL Mol. Cell. Proteomics 9:2369-2390(2010).
CC -!- FUNCTION: Cholecystokinin-22: hypotensive neuropeptide that binds
CC cholecystokinin receptor type A receptor (CCKAR).
CC {ECO:0000269|PubMed:20631207}.
CC -!- FUNCTION: Cholecystokinin-8: hypotensive neuropeptide that binds
CC cholecystokinin receptor type A receptor (CCKAR).
CC {ECO:0000269|PubMed:20631207}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the mandibular venom gland.
CC -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
CC {ECO:0000305}.
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DR EMBL; GU441461; ADK39225.1; -; mRNA.
DR AlphaFoldDB; E2E4E4; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
DR InterPro; IPR015499; CCK-like.
DR InterPro; IPR001651; Gastrin/CCK.
DR InterPro; IPR013152; Gastrin/cholecystokinin_CS.
DR PANTHER; PTHR10786; PTHR10786; 1.
DR Pfam; PF00918; Gastrin; 1.
DR PROSITE; PS00259; GASTRIN; 1.
PE 2: Evidence at transcript level;
KW Amidation; Cleavage on pair of basic residues;
KW G-protein coupled receptor impairing toxin; Hypotensive agent; Secreted;
KW Signal; Sulfation; Toxin.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT PROPEP 21..79
FT /evidence="ECO:0000250"
FT /id="PRO_0000412832"
FT PEPTIDE 80..101
FT /note="Cholecystoxin-22"
FT /id="PRO_0000412833"
FT PEPTIDE 94..101
FT /note="Cholecystoxin-8"
FT /id="PRO_0000412834"
FT PROPEP 102..113
FT /evidence="ECO:0000250"
FT /id="PRO_0000412835"
FT REGION 77..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..97
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 95
FT /note="Sulfotyrosine"
FT /evidence="ECO:0000250"
FT MOD_RES 101
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000250"
SQ SEQUENCE 113 AA; 12541 MW; 33DB9248D64D10D1 CRC64;
MYGGICLCVL LAVLAISSSG QHISRSLNGN SLAAAIEQNF PEKHRPARTP DSNQRVESNI
DEKANLGVLL ARYLQKARRG TNGKPPDPKK ESQDYLGWMD FGRRSAEEYE YSS
