ID   CCTQ_TALIS              Reviewed;         252 AA.
AC   A0A0U1LSP7;
DT   18-JAN-2017, integrated into UniProtKB/Swiss-Prot.
DT   17-FEB-2016, sequence version 1.
DT   25-MAY-2022, entry version 17.
DE   RecName: Full=Probable MFS transporter cctQ {ECO:0000303|PubMed:26954535};
DE   AltName: Full=Cyclochlorotine biosynthesis protein Q {ECO:0000303|PubMed:26954535};
GN   Name=cctQ {ECO:0000303|PubMed:26954535}; ORFNames=PISL3812_02622;
OS   Talaromyces islandicus (Penicillium islandicum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC   Talaromyces sect. Islandici.
OX   NCBI_TaxID=28573;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 26535 / WF-38-12;
RX   PubMed=26197417; DOI=10.1016/j.jbiotec.2015.07.004;
RA   Schafhauser T., Wibberg D., Rueckert C., Winkler A., Flor L., van Pee K.H.,
RA   Fewer D.P., Sivonen K., Jahn L., Ludwig-Mueller J., Caradec T., Jacques P.,
RA   Huijbers M.M., van Berkel W.J., Weber T., Wohlleben W., Kalinowski J.;
RT   "Draft genome sequence of Talaromyces islandicus ('Penicillium islandicum')
RT   WF-38-12, a neglected mold with significant biotechnological potential.";
RL   J. Biotechnol. 211:101-102(2015).
RN   [2]
RP   FUNCTION.
RX   PubMed=26954535; DOI=10.1111/1462-2920.13294;
RA   Schafhauser T., Kirchner N., Kulik A., Huijbers M.M., Flor L., Caradec T.,
RA   Fewer D.P., Gross H., Jacques P., Jahn L., Jokela J., Leclere V.,
RA   Ludwig-Mueller J., Sivonen K., van Berkel W.J., Weber T., Wohlleben W.,
RA   van Pee K.H.;
RT   "The cyclochlorotine mycotoxin is produced by the nonribosomal peptide
RT   synthetase CctN in Talaromyces islandicus ('Penicillium islandicum').";
RL   Environ. Microbiol. 18:3728-3741(2016).
CC   -!- FUNCTION: Probable MFS transporter; part of the gene cluster that
CC       mediates the biosynthesis of the mycotoxin cyclochlorotine, a
CC       hepatotoxic and carcinogenic cyclic chlorinated pentapeptide
CC       (PubMed:26954535). With the ABC transporter cctS, is most likely
CC       responsible for cyclochlorotine secretion and thereby may contribute to
CC       intrinsic resistance (PubMed:26954535). {ECO:0000269|PubMed:26954535}.
CC   -!- PATHWAY: Mycotoxin biosynthesis. {ECO:0000305|PubMed:26954535}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; CVMT01000002; CRG85575.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0U1LSP7; -.
DR   EnsemblFungi; CRG85575; CRG85575; PISL3812_02622.
DR   OrthoDB; 1230185at2759; -.
DR   Proteomes; UP000054383; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport; Virulence.
FT   CHAIN           1..252
FT                   /note="Probable MFS transporter cctQ"
FT                   /id="PRO_0000438671"
FT   TRANSMEM        54..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        116..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        208..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        179
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   252 AA;  28151 MW;  57B7CB870CCBA88D CRC64;
     MGQKETFYRN WNGGGDFLRT VFGLGGLDHT NDSPAEQRYV NSLETSSMMA ENDIGSLMPL
     VYTTVAFFVA VVLPHGSPMS NSHSSKKAFA LLNWPRVLTS RNIWSISHGI FAASMFGSFW
     VQSAVGTIPL FGIVGFSWAV TCRIPYYLLH DELYRSSTQR NRQGDDLTDS QGLIHGIHNF
     SICLAQIVVL LMINTVWILA SDDDGDSFLV WFLLLGGACA LLAMYFTTRL REPENIKYEE
     IAMEEGDYGF SE