CCX2_ARATH
ID CCX2_ARATH Reviewed; 559 AA.
AC Q9FKP2;
DT 18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Cation/calcium exchanger 2;
DE AltName: Full=Protein CATION EXCHANGER 8;
GN Name=CCX2; Synonyms=CAX8; OrderedLocusNames=At5g17850;
GN ORFNames=MPI7.1, MVA3.20, MVA3_200;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9679202; DOI=10.1093/dnares/5.2.131;
RA Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence
RT features of the regions of 1,381,565 bp covered by twenty one physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:131-145(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9405937; DOI=10.1093/dnares/4.4.291;
RA Kotani H., Nakamura Y., Sato S., Kaneko T., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. II. Sequence
RT features of the regions of 1,044,062 bp covered by thirteen physically
RT assigned P1 clones.";
RL DNA Res. 4:291-300(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11500563; DOI=10.1104/pp.126.4.1646;
RA Maeser P., Thomine S., Schroeder J.I., Ward J.M., Hirschi K., Sze H.,
RA Talke I.N., Amtmann A., Maathuis F.J.M., Sanders D., Harper J.F.,
RA Tchieu J., Gribskov M., Persans M.W., Salt D.E., Kim S.A., Guerinot M.L.;
RT "Phylogenetic relationships within cation transporter families of
RT Arabidopsis.";
RL Plant Physiol. 126:1646-1667(2001).
CC -!- FUNCTION: Membrane-localized H(+)-dependent K(+) and Na(+) transporter.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. Cation/calcium exchanger (CCX) subfamily. {ECO:0000305}.
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DR EMBL; AB011480; BAB11218.1; -; Genomic_DNA.
DR EMBL; AB006706; BAB11218.1; JOINED; Genomic_DNA.
DR EMBL; CP002688; AED92478.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM69450.1; -; Genomic_DNA.
DR RefSeq; NP_001318589.1; NM_001343526.1.
DR RefSeq; NP_197287.1; NM_121791.2.
DR AlphaFoldDB; Q9FKP2; -.
DR BioGRID; 16929; 2.
DR STRING; 3702.AT5G17850.1; -.
DR PaxDb; Q9FKP2; -.
DR PRIDE; Q9FKP2; -.
DR ProteomicsDB; 223964; -.
DR EnsemblPlants; AT5G17850.1; AT5G17850.1; AT5G17850.
DR EnsemblPlants; AT5G17850.2; AT5G17850.2; AT5G17850.
DR GeneID; 831653; -.
DR Gramene; AT5G17850.1; AT5G17850.1; AT5G17850.
DR Gramene; AT5G17850.2; AT5G17850.2; AT5G17850.
DR KEGG; ath:AT5G17850; -.
DR Araport; AT5G17850; -.
DR TAIR; locus:2175996; AT5G17850.
DR eggNOG; KOG2399; Eukaryota.
DR HOGENOM; CLU_004979_1_2_1; -.
DR InParanoid; Q9FKP2; -.
DR OMA; KCAYLKS; -.
DR OrthoDB; 478735at2759; -.
DR PhylomeDB; Q9FKP2; -.
DR PRO; PR:Q9FKP2; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FKP2; baseline and differential.
DR Genevisible; Q9FKP2; AT.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0008324; F:cation transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006812; P:cation transport; IBA:GO_Central.
DR GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR GO; GO:0006970; P:response to osmotic stress; IMP:TAIR.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1420.30; -; 2.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR Pfam; PF01699; Na_Ca_ex; 2.
PE 3: Inferred from homology;
KW Antiport; Ion transport; Membrane; Potassium; Potassium transport;
KW Reference proteome; Sodium; Sodium transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..559
FT /note="Cation/calcium exchanger 2"
FT /id="PRO_0000416823"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 331..351
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 362..382
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 393..413
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 416..436
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 480..500
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 506..526
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 531..551
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 559 AA; 61181 MW; B9AEC31E71F19408 CRC64;
MGFSFSSNRF GYLTVTFLLV ISCLLLGFFT NPVDSSALRP KSEHDCSALK HFHDYKSKCA
YLKSIDPCAS QGFFDYLSFL YCNFEGFPIL GQFLLFLWLL LLFYLLGHTA SEYFCSSLES
LSKLLNLSPT VAGVTLLSLG NGAPDLFASL VSFMGESKGT YDVGLNTVVG GSGFVTCVVV
GIISISLHKR RVRIERAAFI RDICFFCAAI GSLALILVYG KINFWGALGF CSLYAVYVAF
VVLSWRFGGD QGAESDLESI HKRGSLSEPI LQRDGLEEIE DGVVNGEHQI VDDDDDHQRY
YYWKRLVIWA ITLPLNLPRI LTIPVVSEDK WSKPLAVASV TFAPVLLSFL WNWKRKPTSF
EAGVVYLIGC LIGIALGFIA GATTKKLTPP KKWLLPWLAG GFVMSMTWSY ISAQELVALL
TSLGYIFGVS PSILGLTVLA WGNSIGDLIT NLTMALHDGN EGAQVAVSGC YAGPIFNTLF
ALGISLVGCA WEAYPLSIVI KTDPRLLESL GFLVAGLVWS FLVLFSNRMR LGGVMGIGLL
VIYLASLSLR IMQTVGDAH
