CCX3_ARATH
ID CCX3_ARATH Reviewed; 643 AA.
AC Q9LJI2;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Cation/calcium exchanger 3;
DE Short=AtCCX3;
DE AltName: Full=Protein CATION CALCIUM EXCHANGER 3;
DE AltName: Full=Protein CATION EXCHANGER 9;
GN Name=CCX3; Synonyms=CAX9; OrderedLocusNames=At3g14070; ORFNames=MAG2.9;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT clones.";
RL DNA Res. 7:217-221(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11500563; DOI=10.1104/pp.126.4.1646;
RA Maeser P., Thomine S., Schroeder J.I., Ward J.M., Hirschi K., Sze H.,
RA Talke I.N., Amtmann A., Maathuis F.J.M., Sanders D., Harper J.F.,
RA Tchieu J., Gribskov M., Persans M.W., Salt D.E., Kim S.A., Guerinot M.L.;
RT "Phylogenetic relationships within cation transporter families of
RT Arabidopsis.";
RL Plant Physiol. 126:1646-1667(2001).
RN [4]
RP FUNCTION, DISRUPTION PHENOTYPE, INDUCTION, TISSUE SPECIFICITY, AND
RP SUBCELLULAR LOCATION.
RX PubMed=18775974; DOI=10.1104/pp.108.118810;
RA Morris J., Tian H., Park S., Sreevidya C.S., Ward J.M., Hirschi K.D.;
RT "AtCCX3 is an Arabidopsis endomembrane H+ -dependent K+ transporter.";
RL Plant Physiol. 148:1474-1486(2008).
CC -!- FUNCTION: Endomembrane-localized H(+)-dependent K(+) and Na(+)
CC transporter. May have a function associated with the pollen vacuole
CC during tube elongation and polarized top growth.
CC {ECO:0000269|PubMed:18775974}.
CC -!- SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000269|PubMed:18775974};
CC Multi-pass membrane protein {ECO:0000269|PubMed:18775974}. Endosome
CC membrane {ECO:0000269|PubMed:18775974}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:18775974}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, leaves, stems and flowers.
CC {ECO:0000269|PubMed:18775974}.
CC -!- INDUCTION: Up-regulated by exogenous Na(+), K(+) and Mn(2+).
CC {ECO:0000269|PubMed:18775974}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype.
CC {ECO:0000269|PubMed:18775974}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. Cation/calcium exchanger (CCX) subfamily. {ECO:0000305}.
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DR EMBL; AP000600; BAB02970.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE75462.1; -; Genomic_DNA.
DR RefSeq; NP_566474.1; NM_112262.2.
DR AlphaFoldDB; Q9LJI2; -.
DR STRING; 3702.AT3G14070.1; -.
DR TCDB; 2.A.19.4.7; the ca(2+):cation antiporter (caca) family.
DR PaxDb; Q9LJI2; -.
DR PRIDE; Q9LJI2; -.
DR ProteomicsDB; 223936; -.
DR EnsemblPlants; AT3G14070.1; AT3G14070.1; AT3G14070.
DR GeneID; 820622; -.
DR Gramene; AT3G14070.1; AT3G14070.1; AT3G14070.
DR KEGG; ath:AT3G14070; -.
DR Araport; AT3G14070; -.
DR TAIR; locus:2087507; AT3G14070.
DR eggNOG; KOG2088; Eukaryota.
DR eggNOG; KOG2399; Eukaryota.
DR HOGENOM; CLU_004979_1_1_1; -.
DR InParanoid; Q9LJI2; -.
DR OMA; MNIANEV; -.
DR OrthoDB; 478735at2759; -.
DR PhylomeDB; Q9LJI2; -.
DR PRO; PR:Q9LJI2; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LJI2; baseline and differential.
DR Genevisible; Q9LJI2; AT.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IDA:TAIR.
DR GO; GO:0012505; C:endomembrane system; IDA:TAIR.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005774; C:vacuolar membrane; IDA:TAIR.
DR GO; GO:0005773; C:vacuole; IDA:TAIR.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0008324; F:cation transmembrane transporter activity; IDA:TAIR.
DR GO; GO:0005384; F:manganese ion transmembrane transporter activity; IMP:TAIR.
DR GO; GO:0015079; F:potassium ion transmembrane transporter activity; IMP:TAIR.
DR GO; GO:0015081; F:sodium ion transmembrane transporter activity; IMP:TAIR.
DR GO; GO:0006812; P:cation transport; IBA:GO_Central.
DR GO; GO:0030003; P:cellular cation homeostasis; IDA:TAIR.
DR GO; GO:0043157; P:response to cation stress; IEP:TAIR.
DR Gene3D; 1.20.1420.30; -; 2.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR Pfam; PF01699; Na_Ca_ex; 2.
PE 2: Evidence at transcript level;
KW Antiport; Endosome; Ion transport; Membrane; Potassium;
KW Potassium transport; Reference proteome; Sodium; Sodium transport;
KW Transmembrane; Transmembrane helix; Transport; Vacuole.
FT CHAIN 1..643
FT /note="Cation/calcium exchanger 3"
FT /id="PRO_0000378325"
FT TRANSMEM 18..38
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..232
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 413..433
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 443..463
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 475..495
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 498..518
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 552..572
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 586..606
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 619..639
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 643 AA; 70157 MW; 3A0E0A91731DFA11 CRC64;
MSAVSFLYSS KTPKFRGVFN GICALVLFCF FFDRSELLRN PLLRNASFVN GGSGSTSGGI
TQFMVIRRNA RQIETNGSGN NSSLSSSSTV LCSGLHKHMG YADQCEFLKA NPICSPDGFF
DYLSFFYCSC RDFSILGYMM LGVWLVALFY LLGNTAADYF CCSLEKLSKL LRLPPTVAGV
TLLPLGNGAP DVFASIAAFV GTDKGEVGLN SVLGGAVFVT SVVVGIVSLC VADKEVKIDK
NCFIRDLSFF LFSLVSLLVI LMVGRVTVRI AIAFVSIYVV YAFLVAANVI LRKHAKRFKL
EALTPLLPMQ GSVFSPSVGE DMPMNTPLIE TETEDGPPRL QSLPQWMWAS NVAIYSNHFA
KVSVHDEDRP PWGWIDDTAE VESSSCTKFT SLLEIPLTIP RRLTIPSVEE DTWSKTYAVA
SVSLAPVLLA SLWSSQDDVS LQACGVAYFF SVVIGSTLGF LAYKNTEPDH PPRRFLIPWV
LGGFIMSIVW FYMIANELVA LLVTFGEIYG INPSILALTV LAWGNSMGDL VSNIALTMNG
GDGVQIALSG CYAGPMFNTL VGLGMSMLFG AWSKSPDTYM LPEDKSLFYT LGFLVLGLVW
AMVILPRNDM QPSRTLGVGL IAIYLIFVTF RLSCAMGFIP WAA
