CCX4_ARATH
ID CCX4_ARATH Reviewed; 644 AA.
AC Q9SYG9;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Cation/calcium exchanger 4;
DE Short=AtCCX4;
DE AltName: Full=Protein CATION CALCIUM EXCHANGER 4;
DE AltName: Full=Protein CATION EXCHANGER 10;
GN Name=CCX4; Synonyms=CAX10; OrderedLocusNames=At1g54115; ORFNames=F15I1.21;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11500563; DOI=10.1104/pp.126.4.1646;
RA Maeser P., Thomine S., Schroeder J.I., Ward J.M., Hirschi K., Sze H.,
RA Talke I.N., Amtmann A., Maathuis F.J.M., Sanders D., Harper J.F.,
RA Tchieu J., Gribskov M., Persans M.W., Salt D.E., Kim S.A., Guerinot M.L.;
RT "Phylogenetic relationships within cation transporter families of
RT Arabidopsis.";
RL Plant Physiol. 126:1646-1667(2001).
RN [4]
RP FUNCTION, DISRUPTION PHENOTYPE, AND TISSUE SPECIFICITY.
RX PubMed=18775974; DOI=10.1104/pp.108.118810;
RA Morris J., Tian H., Park S., Sreevidya C.S., Ward J.M., Hirschi K.D.;
RT "AtCCX3 is an Arabidopsis endomembrane H+ -dependent K+ transporter.";
RL Plant Physiol. 148:1474-1486(2008).
CC -!- FUNCTION: Membrane-localized H(+)-dependent K(+) and Na(+) transporter.
CC {ECO:0000250, ECO:0000269|PubMed:18775974}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, leaves, stems, flowers and
CC pollen. {ECO:0000269|PubMed:18775974}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype.
CC {ECO:0000269|PubMed:18775974}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. Cation/calcium exchanger (CCX) subfamily. {ECO:0000305}.
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DR EMBL; AC006577; AAD25785.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE33051.1; -; Genomic_DNA.
DR PIR; B96582; B96582.
DR RefSeq; NP_564650.1; NM_104289.3.
DR AlphaFoldDB; Q9SYG9; -.
DR STRING; 3702.AT1G54115.1; -.
DR PaxDb; Q9SYG9; -.
DR PRIDE; Q9SYG9; -.
DR ProteomicsDB; 223965; -.
DR EnsemblPlants; AT1G54115.1; AT1G54115.1; AT1G54115.
DR GeneID; 841851; -.
DR Gramene; AT1G54115.1; AT1G54115.1; AT1G54115.
DR KEGG; ath:AT1G54115; -.
DR Araport; AT1G54115; -.
DR TAIR; locus:505006185; AT1G54115.
DR eggNOG; KOG2399; Eukaryota.
DR HOGENOM; CLU_004979_1_1_1; -.
DR InParanoid; Q9SYG9; -.
DR OMA; EDIPMYS; -.
DR OrthoDB; 478735at2759; -.
DR PhylomeDB; Q9SYG9; -.
DR PRO; PR:Q9SYG9; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SYG9; baseline and differential.
DR Genevisible; Q9SYG9; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0008324; F:cation transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006812; P:cation transport; IDA:TAIR.
DR GO; GO:0010150; P:leaf senescence; IGI:TAIR.
DR GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1420.30; -; 2.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR Pfam; PF01699; Na_Ca_ex; 2.
PE 2: Evidence at transcript level;
KW Antiport; Ion transport; Membrane; Potassium; Potassium transport;
KW Reference proteome; Sodium; Sodium transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..644
FT /note="Cation/calcium exchanger 4"
FT /id="PRO_0000378326"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..263
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..290
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 414..434
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 444..464
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 475..495
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 499..519
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 553..573
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 587..607
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 619..639
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 644 AA; 70801 MW; EC6D816F756B1EAC CRC64;
MRAVNFMYSS NNPKFRGIFN GLCAIILFIF FFDQSDIYRN PLLKNLSFVD SSGKFNRGFS
QFTVPRRHLS EVDTNGSSGN SSLSGDSTVS CSGLHEHRGY ADQCEFLKSN PICSPDGFFD
YLKFFYCSCR DFKILGYILL GVWLVALFYL LGNTAADYFC CSLEKLSKLL RLPPTVAGVT
LLPLGNGAPD VFASIAAFVG SDKGEVGLNS VLGGAVFVTC VVVGIVSLCV ADKEVKIDKK
CFIRDLSFFL FTLVALMVIL MVGKVTVGIA IAFVSIYVFY ASLVAANEIL RKHSRRLKLD
SITPLLPMQG SVFSSPSVEE DIPMYSPLME LDTGEGPPRL HDSLPQWMWA TNVAIYSNHF
AKANVHDEER PPWGWTEDGA EVESSLCSKI TSLLETPLTV PRRLTIPLIE EDSWSKTYAV
ASVSLAPVLL SFLWSSQDDT SLQARIVAYF IGIAIGSTLG YLAFKNTEPD RPPQIYLIPW
VLGGFIMSIV WFYMIANELV ALLVTFGGIY GINPSILGLT VLAWGNSMGD LVSNIALSMN
GGDGVQIALS GCYAGPMFNT LVGLGMSMFL GAWSKSPETY MIPEDNSLFY TLGFLIFGLI
WSLVMLPRNE MRPNKVMGIG LITLYLIFVT FRLSSAMGFI PWAS
