CCX5_ARATH
ID CCX5_ARATH Reviewed; 546 AA.
AC O04034;
DT 18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Cation/calcium exchanger 5;
DE AltName: Full=Protein CATION EXCHANGER 11;
GN Name=CCX5; Synonyms=CAX11; OrderedLocusNames=At1g08960; ORFNames=F7G19.17;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Carninci P., Hayashizaki Y.,
RA Ishida J., Kamiya A., Kawai J., Narusaka M., Sakurai T., Satou M., Seki M.,
RA Shinozaki K., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11500563; DOI=10.1104/pp.126.4.1646;
RA Maeser P., Thomine S., Schroeder J.I., Ward J.M., Hirschi K., Sze H.,
RA Talke I.N., Amtmann A., Maathuis F.J.M., Sanders D., Harper J.F.,
RA Tchieu J., Gribskov M., Persans M.W., Salt D.E., Kim S.A., Guerinot M.L.;
RT "Phylogenetic relationships within cation transporter families of
RT Arabidopsis.";
RL Plant Physiol. 126:1646-1667(2001).
RN [6]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=21945443; DOI=10.1016/j.bbrc.2011.09.030;
RA Zhang X., Zhang M., Takano T., Liu S.;
RT "Characterization of an AtCCX5 gene from Arabidopsis thaliana that involves
RT in high-affinity K uptake and Na transport in yeast.";
RL Biochem. Biophys. Res. Commun. 414:96-100(2011).
CC -!- FUNCTION: Membrane-localized H(+)-dependent K(+) and Na(+) transporter.
CC {ECO:0000269|PubMed:21945443}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21945443};
CC Multi-pass membrane protein {ECO:0000269|PubMed:21945443}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. Cation/calcium exchanger (CCX) subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC000106; AAB70411.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE28373.1; -; Genomic_DNA.
DR EMBL; BT012294; AAS76781.1; -; mRNA.
DR EMBL; AK221635; BAD95271.1; -; mRNA.
DR PIR; D86221; D86221.
DR RefSeq; NP_172370.3; NM_100767.6.
DR AlphaFoldDB; O04034; -.
DR BioGRID; 22657; 14.
DR IntAct; O04034; 14.
DR STRING; 3702.AT1G08960.1; -.
DR TCDB; 2.A.19.4.8; the ca(2+):cation antiporter (caca) family.
DR PaxDb; O04034; -.
DR PRIDE; O04034; -.
DR ProteomicsDB; 224467; -.
DR EnsemblPlants; AT1G08960.1; AT1G08960.1; AT1G08960.
DR GeneID; 837416; -.
DR Gramene; AT1G08960.1; AT1G08960.1; AT1G08960.
DR KEGG; ath:AT1G08960; -.
DR Araport; AT1G08960; -.
DR TAIR; locus:2036049; AT1G08960.
DR eggNOG; KOG2399; Eukaryota.
DR HOGENOM; CLU_004979_1_1_1; -.
DR InParanoid; O04034; -.
DR OMA; IYLWQAV; -.
DR OrthoDB; 478735at2759; -.
DR PhylomeDB; O04034; -.
DR PRO; PR:O04034; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; O04034; baseline and differential.
DR Genevisible; O04034; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0034399; C:nuclear periphery; IDA:TAIR.
DR GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0008324; F:cation transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015079; F:potassium ion transmembrane transporter activity; IDA:TAIR.
DR GO; GO:0015081; F:sodium ion transmembrane transporter activity; IDA:TAIR.
DR GO; GO:0006812; P:cation transport; IBA:GO_Central.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IDA:TAIR.
DR GO; GO:0006814; P:sodium ion transport; IDA:TAIR.
DR Gene3D; 1.20.1420.30; -; 2.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR Pfam; PF01699; Na_Ca_ex; 2.
PE 2: Evidence at transcript level;
KW Antiport; Cell membrane; Ion transport; Membrane; Potassium;
KW Potassium transport; Reference proteome; Sodium; Sodium transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..546
FT /note="Cation/calcium exchanger 5"
FT /id="PRO_0000416824"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 218..238
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 323..343
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 356..376
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 388..408
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 423..445
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 455..475
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 492..512
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 522..542
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 546 AA; 59801 MW; DA1729BF3A12BC5F CRC64;
MELISSSTIG NSALCLTLIS ILIFFFLTTT TIPTFPDHPL RSLLDDSQIT TNSSSIVNPK
SSCVSSRSHD NGGVINYFSL HYCIFNENLF FSIPILSLLI LLHFYILIKT AQTHFSTVTT
KLADRLNLSP SMAAVTLLAL GNGAPDVFAS VAALRGGQYR TGFGAILSAG TFVSAFVVGF
VAIYAAPFPV DAASFVRDVL FYLIAALFLF YVYLSGEIFV WQAIGFVGFY IFFVGFVFWM
DFGTNVEKGK SISEEEKDLL RLQDCEIAAG SLGSYKAEKE HQFSGIFRLY GTISRMWETP
VSVLLNLTIP KPSPSEWSRF YRSANIVFCP FALLYTCNSF VQLNHPISFL FPNTHLPLWL
VVLFMTSSLA FLHFTVEKQP PKTEQLPVIV VAFIMSVFWI STIAGELLNC LAALGTLLKL
PPALLGLTVL AWGNSVGDLV ADVAVAKAGR PAMAMAGCFA GPMFNMLVGL GSALVMQTAN
VYPDAYKLGF HVGIVIAFVF LLLSLMGSLL VITWSRFRVP RFWGICLVGL YVAFTFVSLI
IASVST
