ID   CCYL2_HUMAN             Reviewed;         361 AA.
AC   Q5T2Q4;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 2.
DT   25-MAY-2022, entry version 112.
DE   RecName: Full=Cyclin-Y-like protein 2;
GN   Name=CCNYL2; Synonyms=C10orf21;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA   Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA   Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA   Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA   Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA   Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA   Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA   Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA   McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA   Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA   Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA   Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA   Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA   Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA   Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA   Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
CC   -!- SIMILARITY: Belongs to the cyclin family. Cyclin Y subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AL391099; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; Q5T2Q4; -.
DR   SMR; Q5T2Q4; -.
DR   iPTMnet; Q5T2Q4; -.
DR   PhosphoSitePlus; Q5T2Q4; -.
DR   BioMuta; HGNC:23495; -.
DR   DMDM; 162416272; -.
DR   MassIVE; Q5T2Q4; -.
DR   MaxQB; Q5T2Q4; -.
DR   PaxDb; Q5T2Q4; -.
DR   PeptideAtlas; Q5T2Q4; -.
DR   PRIDE; Q5T2Q4; -.
DR   ProteomicsDB; 64352; -.
DR   GeneCards; CCNYL2; -.
DR   HGNC; HGNC:23495; CCNYL2.
DR   neXtProt; NX_Q5T2Q4; -.
DR   InParanoid; Q5T2Q4; -.
DR   PhylomeDB; Q5T2Q4; -.
DR   TreeFam; TF314464; -.
DR   ChiTaRS; CCNYL2; human.
DR   Pharos; Q5T2Q4; Tdark.
DR   PRO; PR:Q5T2Q4; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q5T2Q4; protein.
DR   GO; GO:0000308; C:cytoplasmic cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0061575; F:cyclin-dependent protein serine/threonine kinase activator activity; IBA:GO_Central.
DR   GO; GO:0019901; F:protein kinase binding; IEA:InterPro.
DR   GO; GO:0060828; P:regulation of canonical Wnt signaling pathway; IBA:GO_Central.
DR   GO; GO:0045859; P:regulation of protein kinase activity; IBA:GO_Central.
DR   InterPro; IPR013763; Cyclin-like.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR013922; Cyclin_PHO80-like.
DR   InterPro; IPR012399; Cyclin_Y.
DR   Pfam; PF08613; Cyclin; 1.
DR   PIRSF; PIRSF028934; Cyclin_CG14939; 1.
DR   SMART; SM00385; CYCLIN; 1.
DR   SUPFAM; SSF47954; SSF47954; 1.
PE   3: Inferred from homology;
KW   Cyclin; Reference proteome.
FT   CHAIN           1..361
FT                   /note="Cyclin-Y-like protein 2"
FT                   /id="PRO_0000311816"
FT   DOMAIN          204..286
FT                   /note="Cyclin N-terminal"
FT   VARIANT         57
FT                   /note="V -> E (in dbSNP:rs2490085)"
FT                   /id="VAR_037297"
FT   VARIANT         176
FT                   /note="R -> Q (in dbSNP:rs2489720)"
FT                   /id="VAR_037298"
FT   VARIANT         288
FT                   /note="I -> V (in dbSNP:rs2505861)"
FT                   /id="VAR_037299"
SQ   SEQUENCE   361 AA;  41278 MW;  03CA99A71832235A CRC64;
     MGNILTCCVC PRASPGLHQH QGLVCHCESE IYEAAAGDLI AGVPVAAAVE PGEVTFVAGE
     GLHMHHICER EMPEDIPLEP NPSDHPKAST IFLRKSQTDV QEKKKKQLCK VSTEHFTQQY
     SSCSTIFLDD SIASQPHLTM TLKSCDLGTI LSYQAKRDAH RSLGIFDEQL HPLTVRKEVL
     EEYFKYDPEH KLIFRFVRTL FKAMRLTAEF AIVSLIYIER LVSYADIDIC PTNWKRIVLG
     AILLASKVWS DMAVWNEDYC KLFKNITVEE MNELERQFLK LINYNNSITN SVYSRFYFDL
     RTLAHNNGLY SPVYLLDRER AWKLEAFSRM EQDKVFYSAA KNGSLSADDL IHLQRAKAIL
     F