ID   CCZ1_BOVIN              Reviewed;         480 AA.
AC   Q0VD30;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Vacuolar fusion protein CCZ1 homolog;
GN   Name=CCZ1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts in concert with MON1A, as a guanine exchange factor
CC       (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from
CC       an inactive GDP-bound form into an active GTP-bound form.
CC       {ECO:0000250|UniProtKB:P86791}.
CC   -!- SUBUNIT: Interacts with MON1A. Found in a complex with RMC1, CCZ1,
CC       MON1A and MON1B. {ECO:0000250|UniProtKB:P86791}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CCZ1 family. {ECO:0000305}.
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DR   EMBL; BC119863; AAI19864.1; -; mRNA.
DR   RefSeq; NP_001068960.1; NM_001075492.1.
DR   AlphaFoldDB; Q0VD30; -.
DR   SMR; Q0VD30; -.
DR   STRING; 9913.ENSBTAP00000004259; -.
DR   PaxDb; Q0VD30; -.
DR   PRIDE; Q0VD30; -.
DR   Ensembl; ENSBTAT00000004259; ENSBTAP00000004259; ENSBTAG00000003288.
DR   GeneID; 511088; -.
DR   KEGG; bta:511088; -.
DR   CTD; 51622; -.
DR   VEuPathDB; HostDB:ENSBTAG00000003288; -.
DR   eggNOG; KOG2622; Eukaryota.
DR   GeneTree; ENSGT00390000004713; -.
DR   HOGENOM; CLU_037828_2_0_1; -.
DR   InParanoid; Q0VD30; -.
DR   OMA; FLRAQNF; -.
DR   OrthoDB; 448107at2759; -.
DR   TreeFam; TF314962; -.
DR   Proteomes; UP000009136; Chromosome 25.
DR   Bgee; ENSBTAG00000003288; Expressed in oocyte and 108 other tissues.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0035658; C:Mon1-Ccz1 complex; ISS:UniProtKB.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   InterPro; IPR013176; Ccz1.
DR   InterPro; IPR043987; CCZ1/INTU/HSP4_longin_1.
DR   InterPro; IPR043989; CCZ1/INTU/HSP4_longin_3.
DR   InterPro; IPR043988; CCZ1/INTU_longin_2.
DR   PANTHER; PTHR13056; PTHR13056; 1.
DR   Pfam; PF19031; Intu_longin_1; 1.
DR   Pfam; PF19032; Intu_longin_2; 1.
DR   Pfam; PF19033; Intu_longin_3; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Guanine-nucleotide releasing factor; Lysosome; Membrane;
KW   Phosphoprotein; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:P86791"
FT   CHAIN           2..480
FT                   /note="Vacuolar fusion protein CCZ1 homolog"
FT                   /id="PRO_0000327399"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:P86791"
FT   MOD_RES         74
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P86791"
FT   MOD_RES         264
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P86791"
SQ   SEQUENCE   480 AA;  55502 MW;  CC0B9A83EA233D97 CRC64;
     MAAAASGAGA GAAQEKQFPP ALLSFFIYNP RFGPREGEEE NKILFYYPNE VEKNEKIRNV
     GLCEAIVQFT RTFSPSKPAK SLHTQKNRQF FNEPEENFWM VMVVRNPIIE KQSKDGKPVV
     EYQEEELLDK VYSSVLQQCY SMYKLFNGTF LRAMEDGGVK LLKERLEKFF HRYLQTLHLQ
     SCDLLDIFGG ISFFPLDKMT YLKIQSFINR MEESLSIVKY TAFLYNDQLI WSGLEQDDMR
     ILYKYLTTSL FPRHIEPELA GRDSPIRAEM PGNLQHYGRF LTGPLNLNDP EAKCRFPKIF
     VNTDDTYEAL HLIVYKAMSA AVCFMIDASI QPTLDFCRRL DSIVGPQLTV LASDICEQFN
     INKRMSGSEK EPQFKFIYFN HMNLAEKSTV HMRKTPSVSL TSVHPDLMKI LGDINSDFTR
     VDEDEEIIVK AMSDYWVVGK KSDQRELYVI LNQKNANLIE VNEEVKKLCA TQFNNIFFLD