ID   CCZ1_DANRE              Reviewed;         480 AA.
AC   Q803R2;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Vacuolar fusion protein CCZ1 homolog;
GN   Name=ccz1; ORFNames=zgc:55344;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CCZ1 family. {ECO:0000305}.
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DR   EMBL; BC044374; AAH44374.1; -; mRNA.
DR   RefSeq; NP_956428.1; NM_200134.1.
DR   AlphaFoldDB; Q803R2; -.
DR   SMR; Q803R2; -.
DR   STRING; 7955.ENSDARP00000073520; -.
DR   PaxDb; Q803R2; -.
DR   PRIDE; Q803R2; -.
DR   GeneID; 393103; -.
DR   KEGG; dre:393103; -.
DR   CTD; 51622; -.
DR   ZFIN; ZDB-GENE-040426-698; ccz1.
DR   eggNOG; KOG2622; Eukaryota.
DR   InParanoid; Q803R2; -.
DR   OrthoDB; 448107at2759; -.
DR   Reactome; R-DRE-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR   PRO; PR:Q803R2; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0035658; C:Mon1-Ccz1 complex; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   InterPro; IPR013176; Ccz1.
DR   InterPro; IPR043987; CCZ1/INTU/HSP4_longin_1.
DR   InterPro; IPR043989; CCZ1/INTU/HSP4_longin_3.
DR   InterPro; IPR043988; CCZ1/INTU_longin_2.
DR   PANTHER; PTHR13056; PTHR13056; 1.
DR   Pfam; PF19031; Intu_longin_1; 1.
DR   Pfam; PF19032; Intu_longin_2; 1.
DR   Pfam; PF19033; Intu_longin_3; 1.
PE   2: Evidence at transcript level;
KW   Lysosome; Membrane; Reference proteome.
FT   CHAIN           1..480
FT                   /note="Vacuolar fusion protein CCZ1 homolog"
FT                   /id="PRO_0000327401"
SQ   SEQUENCE   480 AA;  55895 MW;  93116CF22F0BE2C5 CRC64;
     MLMISPRMAS GMQEKQYTPS LLSFFIYNPK FGPREGEEEK KILFYHPIEI EKNEKIRNVG
     LCEAIVQFTR TFCPTKPAKS LHTQKNRQFF HEPEENYWMV MVVRNPMVEK PNKDGKPPTV
     EYQEEEIIDS VYGSVLQQCY SMYKLFNGTF SRAFEAGGVE LLTQKLEKFF YRYLQTLHLQ
     SCDLLDVFGG ISFFPLDKMT YLKIQSFVNR VEESLSLVKY TAFLYNDQLI WSGLEQDDMR
     ILYKYLTTSL FPRHTEPELA GRDSPLRPEV AGNLLHYGRF LTGPANLKDP EAKFRFPRIF
     VNTEDSCEEL HLIVYKAMSA AVCFMINASV DLNREFCEKL DSLVGPQLTL LASDICEQYN
     INRRISGPEK EPQFKFIYFN HMNLAEKSTI HMRKMASVSL TSVHPDLMKI LGDINCDFAR
     VDEDEEIIVK AMTDYWVVGK KSDQRELYVI LNQKNANLIE VNEEVKRLCA TQFNNIFFLD