ID   CCZ1_TETNG              Reviewed;         480 AA.
AC   Q4S4I5;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Vacuolar fusion protein CCZ1 homolog;
GN   Name=ccz1; ORFNames=GSTENG00024165001;
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX   NCBI_TaxID=99883;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA   Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA   Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA   Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA   Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA   Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA   McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA   Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA   Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA   Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT   early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CCZ1 family. {ECO:0000305}.
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DR   EMBL; CAAE01014738; CAG04447.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q4S4I5; -.
DR   SMR; Q4S4I5; -.
DR   STRING; 99883.ENSTNIP00000002944; -.
DR   Ensembl; ENSTNIT00000016070; ENSTNIP00000015860; ENSTNIG00000012884.
DR   KEGG; tng:GSTEN00024165G001; -.
DR   GeneTree; ENSGT00390000004713; -.
DR   HOGENOM; CLU_037828_2_0_1; -.
DR   InParanoid; Q4S4I5; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0035658; C:Mon1-Ccz1 complex; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR013176; Ccz1.
DR   InterPro; IPR043987; CCZ1/INTU/HSP4_longin_1.
DR   InterPro; IPR043989; CCZ1/INTU/HSP4_longin_3.
DR   InterPro; IPR043988; CCZ1/INTU_longin_2.
DR   PANTHER; PTHR13056; PTHR13056; 1.
DR   Pfam; PF19031; Intu_longin_1; 1.
DR   Pfam; PF19032; Intu_longin_2; 1.
DR   Pfam; PF19033; Intu_longin_3; 1.
PE   3: Inferred from homology;
KW   Lysosome; Membrane; Reference proteome.
FT   CHAIN           1..480
FT                   /note="Vacuolar fusion protein CCZ1 homolog"
FT                   /id="PRO_0000327402"
SQ   SEQUENCE   480 AA;  55724 MW;  212E795049156A9A CRC64;
     MQMISPRMAS GMQEKQYTPS LLSFFIYNPT FGPREGEEEK KILFYHPSDV EKNEKIRNVG
     LCEAIVQFTR TFCPTKPAKS LHTQKNRQFF FEPENNFWIV MVVRNPMIEK PNKDGKSQTI
     EYQEEEILDT VYGAVVRQCY SMYKLFNGTF ARAMETGGVE LLMQKLEKFF YKYLQTLHLQ
     SSDLLDVFGG ISFFPLDKMT YLKIQSFVNR VEESLSLVKY TAFLYNDQLI WSGLEQDDMR
     ILYKYLTTSL FPRHTEPELA GRDSPLRPEL AGNLLHYGRF LTGPLNLNDP EAKFRFPKIF
     VSAEDGYEEL HLIVYKAMSA AACFMISASV ELTRDFCEQL DKLVGPQLTL LASDICEQFT
     INRRISGPEK EPQFKFIYFN HMNLAEKSTI HMRKTASVCL TSVHPDLMKI LGDINCDFAR
     VDEDEEIIVK AMTDYWVVGK KSDQRELYVI LNQKNANLIE VNEEVKKLCA TQFNNIFFLD