ID   CCZ_ORYSJ               Reviewed;         492 AA.
AC   Q7EY72;
DT   30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Vacuolar fusion protein CCZ1 homolog {ECO:0000305};
GN   Name=CCZ1 {ECO:0000305}; Synonyms=NP70 {ECO:0000305};
GN   OrderedLocusNames=Os08g0427300 {ECO:0000312|EMBL:BAF23756.1},
GN   LOC_Os08g33076 {ECO:0000305};
GN   ORFNames=OJ1663_D06.7 {ECO:0000312|EMBL:BAD01185.1},
GN   OSJNBb0032E15.114 {ECO:0000312|EMBL:BAD01463.1};
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947 {ECO:0000312|EMBL:BAD01463.1};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
CC   -!- FUNCTION: Plays an important role in membrane trafficking through the
CC       secretory apparatus. In complex with MON1, acts as a guanine exchange
CC       factor (GEF) for Rab7 protein family. Promotes the exchange of GDP to
CC       GTP, converting it from an inactive GDP-bound form into an active GTP-
CC       bound form. The active form is involved in protein trafficking from
CC       prevacuolar compartments (PVCs) to vacuoles. May serve as a linker
CC       between Rab5 and Rab7 protein families in PVCs and mediate PVC
CC       maturation. {ECO:0000250|UniProtKB:F4I2S4}.
CC   -!- SUBUNIT: Interacts with MON1. {ECO:0000250|UniProtKB:F4I2S4}.
CC   -!- SUBCELLULAR LOCATION: Endosome {ECO:0000250|UniProtKB:F4I2S4}.
CC       Prevacuolar compartment {ECO:0000250|UniProtKB:F4I2S4}.
CC   -!- SIMILARITY: Belongs to the CCZ1 family. {ECO:0000305}.
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DR   EMBL; AP003898; BAD01185.1; -; Genomic_DNA.
DR   EMBL; AP005734; BAD01463.1; -; Genomic_DNA.
DR   EMBL; AP008214; BAF23756.1; -; Genomic_DNA.
DR   EMBL; AP014964; BAT05515.1; -; Genomic_DNA.
DR   EMBL; AK066491; BAG89996.1; -; mRNA.
DR   RefSeq; XP_015648148.1; XM_015792662.1.
DR   AlphaFoldDB; Q7EY72; -.
DR   SMR; Q7EY72; -.
DR   STRING; 4530.OS08T0427300-01; -.
DR   PaxDb; Q7EY72; -.
DR   PRIDE; Q7EY72; -.
DR   EnsemblPlants; Os08t0427300-01; Os08t0427300-01; Os08g0427300.
DR   GeneID; 4345617; -.
DR   Gramene; Os08t0427300-01; Os08t0427300-01; Os08g0427300.
DR   KEGG; osa:4345617; -.
DR   eggNOG; KOG2622; Eukaryota.
DR   HOGENOM; CLU_037828_1_1_1; -.
DR   InParanoid; Q7EY72; -.
DR   OMA; FLRAQNF; -.
DR   OrthoDB; 448107at2759; -.
DR   Proteomes; UP000000763; Chromosome 8.
DR   Proteomes; UP000059680; Chromosome 8.
DR   ExpressionAtlas; Q7EY72; baseline and differential.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0035658; C:Mon1-Ccz1 complex; IEA:InterPro.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   InterPro; IPR013176; Ccz1.
DR   InterPro; IPR043987; CCZ1/INTU/HSP4_longin_1.
DR   PANTHER; PTHR13056; PTHR13056; 1.
DR   Pfam; PF19031; Intu_longin_1; 1.
PE   2: Evidence at transcript level;
KW   Endosome; Guanine-nucleotide releasing factor; Reference proteome.
FT   CHAIN           1..492
FT                   /note="Vacuolar fusion protein CCZ1 homolog"
FT                   /id="PRO_0000438483"
FT   REGION          255..275
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        255..272
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   492 AA;  54850 MW;  CB153F9F8AD56DE1 CRC64;
     MGLSSAAAGE GPQLCVFDLR RGQQEGQELD KILFFHPTDC PILLQLSVIG LCEGIITFAR
     IFSPDDDCEV IESEKHSHVF YQAEADIWMV LVVEKNKDIE STWRCGALQG ILKEVHSLFT
     MFHGPIRTLL DRQPSAELAR GHLRTFFTDY LSDFNAGKKI QLPTFRDCLK ERGTVQMLTI
     SREVALEVQS LTTVLGSCLG NVMCQSLVLF EDLLVSTTLP PDDTLNLYTY AILRLTPRAL
     LSNATSWSYL RKGTSVHAGP TSSSSNGTAS VERPLQREKL YKGKDGFVAA GSTTSEVRGA
     VAWVPILWFQ QAEDRMHLCV YQHKNITILL LIPASSLING DDGIAHVKRH LLENASQNIV
     TLELKLSRGW GGENAYHVGG YRYLLVDPDR KVSRASPPGK VTTLSKDSLL SLNRLREEID
     LEKSRAKRSD SCHDKDFEVC IRAKNNAWVI AKVTRGRELY MALEKAGETL LYASTAIEKF
     SNRYCEGAFS TD