CD003_MOUSE
ID CD003_MOUSE Reviewed; 65 AA.
AC Q99M08; Q8CEY1;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Uncharacterized protein C4orf3 homolog;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Pancreas, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Kidney, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17208939; DOI=10.1074/mcp.m600218-mcp200;
RA Lee J., Xu Y., Chen Y., Sprung R., Kim S.C., Xie S., Zhao Y.;
RT "Mitochondrial phosphoproteome revealed by an improved IMAC method and
RT MS/MS/MS.";
RL Mol. Cell. Proteomics 6:669-676(2007).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AK007721; BAC25185.1; -; mRNA.
DR EMBL; AK009748; BAC25270.1; -; mRNA.
DR EMBL; AK170776; BAE42021.1; -; mRNA.
DR EMBL; BC002135; AAH02135.1; -; mRNA.
DR EMBL; BC086913; AAH86913.1; -; mRNA.
DR CCDS; CCDS38619.1; -.
DR RefSeq; NP_077781.1; NM_024461.2.
DR AlphaFoldDB; Q99M08; -.
DR SMR; Q99M08; -.
DR BioGRID; 212379; 1.
DR IntAct; Q99M08; 1.
DR STRING; 10090.ENSMUSP00000102037; -.
DR iPTMnet; Q99M08; -.
DR PhosphoSitePlus; Q99M08; -.
DR EPD; Q99M08; -.
DR MaxQB; Q99M08; -.
DR PaxDb; Q99M08; -.
DR PeptideAtlas; Q99M08; -.
DR PRIDE; Q99M08; -.
DR TopDownProteomics; Q99M08; -.
DR Antibodypedia; 26668; 97 antibodies from 14 providers.
DR Ensembl; ENSMUST00000106429; ENSMUSP00000102037; ENSMUSG00000054091.
DR GeneID; 67704; -.
DR KEGG; mmu:67704; -.
DR UCSC; uc008rey.1; mouse.
DR MGI; MGI:1914954; 1810037I17Rik.
DR VEuPathDB; HostDB:ENSMUSG00000054091; -.
DR eggNOG; ENOG502T0GP; Eukaryota.
DR GeneTree; ENSGT00530000064570; -.
DR HOGENOM; CLU_189559_0_0_1; -.
DR InParanoid; Q99M08; -.
DR OMA; DRFPKHS; -.
DR OrthoDB; 1648818at2759; -.
DR PhylomeDB; Q99M08; -.
DR TreeFam; TF343305; -.
DR BioGRID-ORCS; 67704; 3 hits in 69 CRISPR screens.
DR PRO; PR:Q99M08; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q99M08; protein.
DR Bgee; ENSMUSG00000054091; Expressed in esophagus and 66 other tissues.
DR Genevisible; Q99M08; MM.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IDA:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:1901895; P:negative regulation of ATPase-coupled calcium transmembrane transporter activity; IDA:MGI.
DR GO; GO:1901877; P:negative regulation of calcium ion binding; IDA:MGI.
DR InterPro; IPR038780; C4orf3.
DR PANTHER; PTHR37367; PTHR37367; 1.
DR Pfam; PF17696; DUF5542; 1.
PE 1: Evidence at protein level;
KW Acetylation; Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..65
FT /note="Uncharacterized protein C4orf3 homolog"
FT /id="PRO_0000325785"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q8WVX3"
FT MOD_RES 19
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17208939,
FT ECO:0007744|PubMed:19144319"
FT CONFLICT 4
FT /note="S -> T (in Ref. 1; BAC25270)"
FT /evidence="ECO:0000305"
FT CONFLICT 22
FT /note="A -> P (in Ref. 1; BAC25270)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 65 AA; 7404 MW; C84DC06A093A73A2 CRC64;
MEVSQAASGT DGVRERRGSF EAGRRNQDEA PQSGMNGLPK HSYWLDLWLF ILFDLALFVF
VYLLP
