CD017_HUMAN
ID CD017_HUMAN Reviewed; 359 AA.
AC Q53FE4; Q6FI84; Q6IS77; Q8NA78; Q9H0D9;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 3.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Uncharacterized protein C4orf17;
GN Name=C4orf17;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS GLU-64;
RP PRO-85 AND LYS-91.
RC TISSUE=Testis;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS GLU-64;
RP PRO-85 AND LYS-91.
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RA Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
RA Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS GLU-64;
RP PRO-85 AND LYS-91.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q53FE4; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-715110, EBI-11096309;
CC Q53FE4; P28799: GRN; NbExp=3; IntAct=EBI-715110, EBI-747754;
CC Q53FE4; Q9NSC5: HOMER3; NbExp=3; IntAct=EBI-715110, EBI-748420;
CC Q53FE4; Q17RB8: LONRF1; NbExp=3; IntAct=EBI-715110, EBI-2341787;
CC Q53FE4; O43639: NCK2; NbExp=3; IntAct=EBI-715110, EBI-713635;
CC Q53FE4; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-715110, EBI-740727;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q53FE4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q53FE4-2; Sequence=VSP_056907, VSP_056908;
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DR EMBL; AL136838; CAB66772.1; -; mRNA.
DR EMBL; CR533542; CAG38573.1; -; mRNA.
DR EMBL; AK093085; BAC04048.1; -; mRNA.
DR EMBL; AK223345; BAD97065.1; -; mRNA.
DR EMBL; AC083902; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP001960; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC069805; AAH69805.1; -; mRNA.
DR EMBL; BC074759; AAH74759.1; -; mRNA.
DR CCDS; CCDS3649.1; -. [Q53FE4-1]
DR RefSeq; NP_115525.2; NM_032149.2. [Q53FE4-1]
DR AlphaFoldDB; Q53FE4; -.
DR BioGRID; 123892; 15.
DR IntAct; Q53FE4; 14.
DR MINT; Q53FE4; -.
DR STRING; 9606.ENSP00000322582; -.
DR iPTMnet; Q53FE4; -.
DR PhosphoSitePlus; Q53FE4; -.
DR BioMuta; C4orf17; -.
DR MassIVE; Q53FE4; -.
DR PaxDb; Q53FE4; -.
DR PeptideAtlas; Q53FE4; -.
DR PRIDE; Q53FE4; -.
DR Antibodypedia; 63838; 41 antibodies from 11 providers.
DR DNASU; 84103; -.
DR Ensembl; ENST00000326581.9; ENSP00000322582.4; ENSG00000138813.10. [Q53FE4-1]
DR Ensembl; ENST00000477187.1; ENSP00000423411.1; ENSG00000138813.10. [Q53FE4-2]
DR GeneID; 84103; -.
DR KEGG; hsa:84103; -.
DR MANE-Select; ENST00000326581.9; ENSP00000322582.4; NM_032149.3; NP_115525.2.
DR UCSC; uc003huw.3; human. [Q53FE4-1]
DR CTD; 84103; -.
DR DisGeNET; 84103; -.
DR GeneCards; C4orf17; -.
DR HGNC; HGNC:25274; C4orf17.
DR HPA; ENSG00000138813; Tissue enriched (testis).
DR neXtProt; NX_Q53FE4; -.
DR OpenTargets; ENSG00000138813; -.
DR PharmGKB; PA134913125; -.
DR VEuPathDB; HostDB:ENSG00000138813; -.
DR eggNOG; ENOG502SU2P; Eukaryota.
DR GeneTree; ENSGT00510000048844; -.
DR HOGENOM; CLU_134784_0_0_1; -.
DR InParanoid; Q53FE4; -.
DR OMA; KPMSARS; -.
DR OrthoDB; 1111761at2759; -.
DR PhylomeDB; Q53FE4; -.
DR TreeFam; TF330946; -.
DR PathwayCommons; Q53FE4; -.
DR SignaLink; Q53FE4; -.
DR BioGRID-ORCS; 84103; 13 hits in 1036 CRISPR screens.
DR GenomeRNAi; 84103; -.
DR Pharos; Q53FE4; Tdark.
DR PRO; PR:Q53FE4; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q53FE4; protein.
DR Bgee; ENSG00000138813; Expressed in left ventricle myocardium and 37 other tissues.
DR ExpressionAtlas; Q53FE4; baseline and differential.
DR Genevisible; Q53FE4; HS.
DR InterPro; IPR037394; TBATA-like.
DR PANTHER; PTHR33772; PTHR33772; 1.
DR Pfam; PF15256; SPATIAL; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..359
FT /note="Uncharacterized protein C4orf17"
FT /id="PRO_0000089433"
FT REGION 90..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 132..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 235..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 286..303
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..344
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 183..186
FT /note="ILAK -> ATLL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056907"
FT VAR_SEQ 187..359
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056908"
FT VARIANT 64
FT /note="G -> E (in dbSNP:rs13143848)"
FT /evidence="ECO:0000269|PubMed:11230166,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.2"
FT /id="VAR_028110"
FT VARIANT 85
FT /note="S -> P (in dbSNP:rs13119384)"
FT /evidence="ECO:0000269|PubMed:11230166,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.2"
FT /id="VAR_028111"
FT VARIANT 91
FT /note="E -> K (in dbSNP:rs17029087)"
FT /evidence="ECO:0000269|PubMed:11230166,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.2"
FT /id="VAR_028112"
FT CONFLICT 289
FT /note="K -> R (in Ref. 2; CAG38573)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 359 AA; 39644 MW; CA29C013A6D13273 CRC64;
MNLNPPTSAL QIEGKGSHIM ARNVSCFLVR HTPHPRRVCH IKGLNNIPIC TVNDDENAFG
TLWGVGQSNY LEKNRIPFAN CSYPSSTAVQ ESPVRGMSPA PNGAKVPPRP HSEPSRKIKE
CFKTSSENPL VIKKEEIKAK RPPSPPKACS TPGSCSSGMT STKNDVKANT ICIPNYLDQE
IKILAKLCSI LHTDSLAEVL QWLLHATSKE KEWVSALIHS ELAEINLLTH HRRNTSMEPA
AETGKPPTVK SPPTVKLPPN FTAKSKVLTR DTEGDQPTRV SSQGSEENKE VPKEAEHKPP
LLIRRNNMKI PVAEYFSKPN SPPRPNTQES GSAKPVSARS IQEYNLCPQR ACYPSTHRR
