CD019_HUMAN
ID CD019_HUMAN Reviewed; 314 AA.
AC Q8IY42; Q9NV03;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Uncharacterized protein C4orf19;
GN Name=C4orf19;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLY-274.
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30 AND SER-238, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- INTERACTION:
CC Q8IY42; Q9NX38: ABITRAM; NbExp=3; IntAct=EBI-10216552, EBI-9105722;
CC Q8IY42; Q96LK0: CEP19; NbExp=3; IntAct=EBI-10216552, EBI-741885;
CC Q8IY42; P60228: EIF3E; NbExp=4; IntAct=EBI-10216552, EBI-347740;
CC Q8IY42; Q9BUL8: PDCD10; NbExp=8; IntAct=EBI-10216552, EBI-740195;
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DR EMBL; AK001879; BAA91958.1; -; mRNA.
DR EMBL; BC037906; AAH37906.1; -; mRNA.
DR CCDS; CCDS3442.1; -.
DR RefSeq; NP_001098099.1; NM_001104629.1.
DR RefSeq; NP_060772.2; NM_018302.2.
DR RefSeq; XP_011512014.1; XM_011513712.2.
DR RefSeq; XP_011512015.1; XM_011513713.2.
DR RefSeq; XP_016863850.1; XM_017008361.1.
DR AlphaFoldDB; Q8IY42; -.
DR BioGRID; 120574; 9.
DR IntAct; Q8IY42; 9.
DR MINT; Q8IY42; -.
DR STRING; 9606.ENSP00000284437; -.
DR iPTMnet; Q8IY42; -.
DR PhosphoSitePlus; Q8IY42; -.
DR BioMuta; C4orf19; -.
DR DMDM; 74728286; -.
DR MassIVE; Q8IY42; -.
DR PaxDb; Q8IY42; -.
DR PeptideAtlas; Q8IY42; -.
DR PRIDE; Q8IY42; -.
DR ProteomicsDB; 71104; -.
DR Antibodypedia; 43802; 72 antibodies from 15 providers.
DR DNASU; 55286; -.
DR Ensembl; ENST00000284437.6; ENSP00000284437.6; ENSG00000154274.15.
DR Ensembl; ENST00000381980.9; ENSP00000371408.4; ENSG00000154274.15.
DR GeneID; 55286; -.
DR KEGG; hsa:55286; -.
DR MANE-Select; ENST00000381980.9; ENSP00000371408.4; NM_001104629.2; NP_001098099.1.
DR UCSC; uc003gsw.5; human.
DR CTD; 55286; -.
DR DisGeNET; 55286; -.
DR GeneCards; C4orf19; -.
DR HGNC; HGNC:25618; C4orf19.
DR HPA; ENSG00000154274; Tissue enhanced (liver).
DR neXtProt; NX_Q8IY42; -.
DR OpenTargets; ENSG00000154274; -.
DR PharmGKB; PA144596500; -.
DR VEuPathDB; HostDB:ENSG00000154274; -.
DR eggNOG; ENOG502S5D9; Eukaryota.
DR GeneTree; ENSGT00390000013778; -.
DR HOGENOM; CLU_076375_0_0_1; -.
DR InParanoid; Q8IY42; -.
DR OMA; GNYVEKD; -.
DR OrthoDB; 1420708at2759; -.
DR PhylomeDB; Q8IY42; -.
DR TreeFam; TF337421; -.
DR PathwayCommons; Q8IY42; -.
DR SignaLink; Q8IY42; -.
DR BioGRID-ORCS; 55286; 14 hits in 1038 CRISPR screens.
DR ChiTaRS; C4orf19; human.
DR GenomeRNAi; 55286; -.
DR Pharos; Q8IY42; Tdark.
DR PRO; PR:Q8IY42; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q8IY42; protein.
DR Bgee; ENSG00000154274; Expressed in amniotic fluid and 159 other tissues.
DR ExpressionAtlas; Q8IY42; baseline and differential.
DR Genevisible; Q8IY42; HS.
DR GO; GO:0030054; C:cell junction; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR InterPro; IPR031528; DUF4699.
DR PANTHER; PTHR16106; PTHR16106; 1.
DR Pfam; PF15770; DUF4699; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..314
FT /note="Uncharacterized protein C4orf19"
FT /id="PRO_0000286561"
FT REGION 36..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 267..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..71
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 30
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 106
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q99K99"
FT MOD_RES 238
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 241
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q99K99"
FT VARIANT 39
FT /note="D -> E (in dbSNP:rs6852908)"
FT /id="VAR_050770"
FT VARIANT 151
FT /note="A -> T (in dbSNP:rs2973275)"
FT /id="VAR_032118"
FT VARIANT 274
FT /note="E -> G (in dbSNP:rs3733500)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_032119"
SQ SEQUENCE 314 AA; 33742 MW; 65A8FEBD0F1B08EA CRC64;
MGCRCCKIIQ SYLFDPVQVP SPGYVNEVNS CKLDEDDTDK LKGKWSSEVL VQKNDPQRQG
SKKTESSSRT ADPWEPCWPH QGPLPQGDAG GEHHACGVNG IGPAATPQPT GNSSPTQDDR
GSWASTANTV PPTQPFLEGG GTRKQDCVLL ASEGTQVMRN GDSRAPSEAE SFALEVQDHV
FQIPAPDYLQ HWGPAGDNVD HNEKDCVFKN HTEDESLEGI QPPVGEHGLN TPFSVRRSWD
SLNEDVETEV LSICFNEKGP VHAMPVVDSG NRQEDTHGSD GDGDGEIVDE DAAVAEALAA
LEAATAGEDL DETD
