CD019_MOUSE
ID CD019_MOUSE Reviewed; 313 AA.
AC Q99K99; Q8BQG8; Q9DCE0;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Uncharacterized protein C4orf19 homolog;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-104 AND SER-107, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60; SER-64; SER-107; SER-237
RP AND SER-240, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP ANALYSIS].
RC TISSUE=Brain, and Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
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DR EMBL; AK002869; BAB22418.1; -; mRNA.
DR EMBL; AK050792; BAC34413.1; -; mRNA.
DR EMBL; AK159779; BAE35363.1; -; mRNA.
DR EMBL; BC004797; AAH04797.1; -; mRNA.
DR CCDS; CCDS39092.1; -.
DR RefSeq; NP_083830.3; NM_029554.4.
DR RefSeq; XP_006504241.1; XM_006504178.3.
DR RefSeq; XP_011239094.1; XM_011240792.2.
DR AlphaFoldDB; Q99K99; -.
DR STRING; 10090.ENSMUSP00000080443; -.
DR iPTMnet; Q99K99; -.
DR PhosphoSitePlus; Q99K99; -.
DR MaxQB; Q99K99; -.
DR PaxDb; Q99K99; -.
DR PRIDE; Q99K99; -.
DR Antibodypedia; 43802; 72 antibodies from 15 providers.
DR DNASU; 76261; -.
DR Ensembl; ENSMUST00000081747; ENSMUSP00000080443; ENSMUSG00000060512.
DR GeneID; 76261; -.
DR KEGG; mmu:76261; -.
DR UCSC; uc008xmg.1; mouse.
DR MGI; MGI:1923511; 0610040J01Rik.
DR VEuPathDB; HostDB:ENSMUSG00000060512; -.
DR eggNOG; ENOG502S5D9; Eukaryota.
DR GeneTree; ENSGT00390000013778; -.
DR HOGENOM; CLU_076375_0_0_1; -.
DR InParanoid; Q99K99; -.
DR OMA; GNYVEKD; -.
DR OrthoDB; 1420708at2759; -.
DR PhylomeDB; Q99K99; -.
DR TreeFam; TF337421; -.
DR BioGRID-ORCS; 76261; 0 hits in 71 CRISPR screens.
DR PRO; PR:Q99K99; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q99K99; protein.
DR Bgee; ENSMUSG00000060512; Expressed in dorsal pancreas and 194 other tissues.
DR ExpressionAtlas; Q99K99; baseline and differential.
DR Genevisible; Q99K99; MM.
DR GO; GO:0030054; C:cell junction; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR InterPro; IPR031528; DUF4699.
DR PANTHER; PTHR16106; PTHR16106; 1.
DR Pfam; PF15770; DUF4699; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..313
FT /note="Uncharacterized protein C4orf19 homolog"
FT /id="PRO_0000286562"
FT REGION 40..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 253..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..77
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..286
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 60
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 64
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 104
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:17242355"
FT MOD_RES 107
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 237
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 240
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 161
FT /note="V -> M (in Ref. 2; AAH04797)"
FT /evidence="ECO:0000305"
FT CONFLICT 194
FT /note="T -> A (in Ref. 2; AAH04797)"
FT /evidence="ECO:0000305"
FT CONFLICT 226
FT /note="L -> Q (in Ref. 2; AAH04797)"
FT /evidence="ECO:0000305"
FT CONFLICT 270
FT /note="S -> N (in Ref. 2; AAH04797)"
FT /evidence="ECO:0000305"
FT CONFLICT 271
FT /note="E -> D (in Ref. 1; BAC34413)"
FT /evidence="ECO:0000305"
FT CONFLICT 272
FT /note="R -> P (in Ref. 2; AAH04797)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 313 AA; 33916 MW; 8BD6A1CB5AE6D0F3 CRC64;
MGCRCCKMIQ SYLFDPVQVP SPGFVNEVNN CKLEEDDTVR LKGTQNSEVE VPRNALHDGS
LSNSESRGST TGLPHQGPLP QEDSEERPCV EKQGIVNGIS PTATLQSVRS SRLHQVDNSS
WASSPWVATI DSAHLAQPFL EGEDYRKQSC LLPTLEGTQM VGHGDCRAPA EALAVADHIP
YIPAPDYPQL WSPTVDNADP EEKDCLFENH SEVEPLPGIQ PRVSQLGLNV PFSLQRSWDS
LNEAGTTEVL SDYFKEEGPT HPTPAADSGS EREDPHTYNG DREGVVVDED AEVAEALAAL
EAATAGEDAD DAD
