CD033_HUMAN
ID CD033_HUMAN Reviewed; 199 AA.
AC Q8N1A6; D3DNY2; Q6PJF3; Q8NBC5;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=UPF0462 protein C4orf33;
GN Name=C4orf33;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS VAL-107 AND ARG-166.
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-107.
RC TISSUE=Endometrium;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-107.
RC TISSUE=Brain, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- INTERACTION:
CC Q8N1A6; P55212: CASP6; NbExp=3; IntAct=EBI-10264911, EBI-718729;
CC Q8N1A6; P13473-2: LAMP2; NbExp=3; IntAct=EBI-10264911, EBI-21591415;
CC Q8N1A6; Q9Y371: SH3GLB1; NbExp=3; IntAct=EBI-10264911, EBI-2623095;
CC Q8N1A6; Q15645: TRIP13; NbExp=7; IntAct=EBI-10264911, EBI-358993;
CC Q8N1A6; Q08AM6: VAC14; NbExp=8; IntAct=EBI-10264911, EBI-2107455;
CC -!- SIMILARITY: Belongs to the UPF0462 family. {ECO:0000305}.
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DR EMBL; AK091022; BAC03568.1; -; mRNA.
DR EMBL; BX538164; CAD98044.1; -; mRNA.
DR EMBL; AC093826; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471056; EAX05162.1; -; Genomic_DNA.
DR EMBL; CH471056; EAX05166.1; -; Genomic_DNA.
DR EMBL; BC016358; AAH16358.1; -; mRNA.
DR EMBL; BC032582; AAH32582.1; -; mRNA.
DR CCDS; CCDS3741.1; -.
DR RefSeq; NP_001093253.1; NM_001099783.1.
DR RefSeq; NP_775758.2; NM_173487.2.
DR RefSeq; XP_005262791.1; XM_005262734.4.
DR AlphaFoldDB; Q8N1A6; -.
DR SMR; Q8N1A6; -.
DR BioGRID; 126319; 5.
DR IntAct; Q8N1A6; 5.
DR STRING; 9606.ENSP00000281146; -.
DR iPTMnet; Q8N1A6; -.
DR PhosphoSitePlus; Q8N1A6; -.
DR BioMuta; C4orf33; -.
DR EPD; Q8N1A6; -.
DR jPOST; Q8N1A6; -.
DR MassIVE; Q8N1A6; -.
DR MaxQB; Q8N1A6; -.
DR PaxDb; Q8N1A6; -.
DR PeptideAtlas; Q8N1A6; -.
DR PRIDE; Q8N1A6; -.
DR ProteomicsDB; 71579; -.
DR Antibodypedia; 27038; 88 antibodies from 19 providers.
DR DNASU; 132321; -.
DR Ensembl; ENST00000281146.9; ENSP00000281146.4; ENSG00000151470.13.
DR Ensembl; ENST00000425929.6; ENSP00000401090.1; ENSG00000151470.13.
DR GeneID; 132321; -.
DR KEGG; hsa:132321; -.
DR MANE-Select; ENST00000425929.6; ENSP00000401090.1; NM_001099783.2; NP_001093253.1.
DR UCSC; uc003igu.5; human.
DR CTD; 132321; -.
DR DisGeNET; 132321; -.
DR GeneCards; C4orf33; -.
DR HGNC; HGNC:27025; C4orf33.
DR HPA; ENSG00000151470; Low tissue specificity.
DR neXtProt; NX_Q8N1A6; -.
DR OpenTargets; ENSG00000151470; -.
DR PharmGKB; PA162379743; -.
DR VEuPathDB; HostDB:ENSG00000151470; -.
DR eggNOG; ENOG502R3ZD; Eukaryota.
DR GeneTree; ENSGT00390000006284; -.
DR InParanoid; Q8N1A6; -.
DR OMA; NGLWDYE; -.
DR OrthoDB; 1462707at2759; -.
DR PhylomeDB; Q8N1A6; -.
DR TreeFam; TF313077; -.
DR PathwayCommons; Q8N1A6; -.
DR SignaLink; Q8N1A6; -.
DR BioGRID-ORCS; 132321; 10 hits in 1050 CRISPR screens.
DR GenomeRNAi; 132321; -.
DR Pharos; Q8N1A6; Tdark.
DR PRO; PR:Q8N1A6; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q8N1A6; protein.
DR Bgee; ENSG00000151470; Expressed in monocyte and 146 other tissues.
DR ExpressionAtlas; Q8N1A6; baseline and differential.
DR Genevisible; Q8N1A6; HS.
DR InterPro; IPR029674; C4orf33.
DR PANTHER; PTHR31475:SF3; PTHR31475:SF3; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..199
FT /note="UPF0462 protein C4orf33"
FT /id="PRO_0000295714"
FT VARIANT 40
FT /note="R -> M (in dbSNP:rs35199409)"
FT /id="VAR_033334"
FT VARIANT 104
FT /note="S -> L (in dbSNP:rs2271570)"
FT /id="VAR_033335"
FT VARIANT 107
FT /note="M -> V (in dbSNP:rs337277)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:17974005"
FT /id="VAR_033336"
FT VARIANT 166
FT /note="H -> R (in dbSNP:rs17351999)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_033337"
FT CONFLICT 130
FT /note="T -> A (in Ref. 1; BAC03568)"
FT /evidence="ECO:0000305"
FT CONFLICT 159
FT /note="Q -> R (in Ref. 5; AAH16358)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 199 AA; 23468 MW; 797E0259540AFAA4 CRC64;
MDFKIEHTWD GFPVKHEPVF IRLNPGDRGV MMDISAPFFR DPPAPLGEPG KPFNELWDYE
VVEAFFLNDI TEQYLEVELC PHGQHLVLLL SGRRNVWKQE LPLSFRMSRG ETKWEGKAYL
PWSYFPPNVT KFNSFAIHGS KDKRSYEALY PVPQHELQQG QKPDFHCLEY FKSFNFNTLL
GEEWKQPESD LWLIEKCDI
