CD045_HUMAN
ID CD045_HUMAN Reviewed; 186 AA.
AC Q96LM5; A8MPU3; C9J0T8;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 3.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Uncharacterized protein C4orf45;
GN Name=C4orf45;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS GLY-75 AND GLU-93.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
CC -!- INTERACTION:
CC Q96LM5; Q8N9N5-2: BANP; NbExp=3; IntAct=EBI-12020542, EBI-11524452;
CC Q96LM5; P41182: BCL6; NbExp=3; IntAct=EBI-12020542, EBI-765407;
CC Q96LM5; Q8N9W6-4: BOLL; NbExp=3; IntAct=EBI-12020542, EBI-11983447;
CC Q96LM5; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-12020542, EBI-3866279;
CC Q96LM5; Q86Z20: CCDC125; NbExp=3; IntAct=EBI-12020542, EBI-11977221;
CC Q96LM5; Q2TAC2-2: CCDC57; NbExp=3; IntAct=EBI-12020542, EBI-10961624;
CC Q96LM5; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-12020542, EBI-3867333;
CC Q96LM5; O60662: KLHL41; NbExp=3; IntAct=EBI-12020542, EBI-5353084;
CC Q96LM5; Q6A162: KRT40; NbExp=3; IntAct=EBI-12020542, EBI-10171697;
CC Q96LM5; Q9UPY8: MAPRE3; NbExp=3; IntAct=EBI-12020542, EBI-726739;
CC Q96LM5; Q99750: MDFI; NbExp=3; IntAct=EBI-12020542, EBI-724076;
CC Q96LM5; Q9BU76: MMTAG2; NbExp=3; IntAct=EBI-12020542, EBI-742459;
CC Q96LM5; Q8NI38: NFKBID; NbExp=3; IntAct=EBI-12020542, EBI-10271199;
CC Q96LM5; Q99471: PFDN5; NbExp=3; IntAct=EBI-12020542, EBI-357275;
CC Q96LM5; O15160: POLR1C; NbExp=3; IntAct=EBI-12020542, EBI-1055079;
CC Q96LM5; O75400-2: PRPF40A; NbExp=3; IntAct=EBI-12020542, EBI-5280197;
CC Q96LM5; Q8N9Q2: SREK1IP1; NbExp=3; IntAct=EBI-12020542, EBI-10268630;
CC Q96LM5; Q9NVV9: THAP1; NbExp=3; IntAct=EBI-12020542, EBI-741515;
CC Q96LM5; Q13077: TRAF1; NbExp=3; IntAct=EBI-12020542, EBI-359224;
CC Q96LM5; Q86WT6-2: TRIM69; NbExp=3; IntAct=EBI-12020542, EBI-11525489;
CC Q96LM5; O43167: ZBTB24; NbExp=3; IntAct=EBI-12020542, EBI-744471;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB71665.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK058100; BAB71665.1; ALT_FRAME; mRNA.
DR EMBL; AC093700; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC109823; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS47156.1; -.
DR RefSeq; NP_689756.2; NM_152543.2.
DR RefSeq; XP_016863297.1; XM_017007808.1.
DR RefSeq; XP_016863298.1; XM_017007809.1.
DR RefSeq; XP_016863299.1; XM_017007810.1.
DR AlphaFoldDB; Q96LM5; -.
DR SMR; Q96LM5; -.
DR BioGRID; 127473; 22.
DR IntAct; Q96LM5; 22.
DR MINT; Q96LM5; -.
DR STRING; 9606.ENSP00000412215; -.
DR iPTMnet; Q96LM5; -.
DR PhosphoSitePlus; Q96LM5; -.
DR BioMuta; C4orf45; -.
DR DMDM; 296439413; -.
DR MassIVE; Q96LM5; -.
DR PaxDb; Q96LM5; -.
DR PeptideAtlas; Q96LM5; -.
DR PRIDE; Q96LM5; -.
DR Antibodypedia; 56684; 23 antibodies from 6 providers.
DR DNASU; 152940; -.
DR Ensembl; ENST00000434826.3; ENSP00000412215.2; ENSG00000164123.7.
DR GeneID; 152940; -.
DR KEGG; hsa:152940; -.
DR MANE-Select; ENST00000434826.3; ENSP00000412215.2; NM_152543.3; NP_689756.2.
DR UCSC; uc003iqf.2; human.
DR CTD; 152940; -.
DR DisGeNET; 152940; -.
DR GeneCards; C4orf45; -.
DR HGNC; HGNC:26342; C4orf45.
DR HPA; ENSG00000164123; Tissue enriched (testis).
DR neXtProt; NX_Q96LM5; -.
DR OpenTargets; ENSG00000164123; -.
DR PharmGKB; PA162379953; -.
DR VEuPathDB; HostDB:ENSG00000164123; -.
DR eggNOG; ENOG502S3MZ; Eukaryota.
DR GeneTree; ENSGT00390000012736; -.
DR HOGENOM; CLU_105465_0_0_1; -.
DR InParanoid; Q96LM5; -.
DR OMA; DRRNSKW; -.
DR OrthoDB; 1526686at2759; -.
DR PhylomeDB; Q96LM5; -.
DR TreeFam; TF329701; -.
DR PathwayCommons; Q96LM5; -.
DR SignaLink; Q96LM5; -.
DR BioGRID-ORCS; 152940; 18 hits in 1037 CRISPR screens.
DR ChiTaRS; C4orf45; human.
DR GenomeRNAi; 152940; -.
DR Pharos; Q96LM5; Tdark.
DR PRO; PR:Q96LM5; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q96LM5; protein.
DR Bgee; ENSG00000164123; Expressed in sperm and 88 other tissues.
DR Genevisible; Q96LM5; HS.
DR InterPro; IPR027814; DUF4562.
DR PANTHER; PTHR34833; PTHR34833; 1.
DR Pfam; PF15123; DUF4562; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..186
FT /note="Uncharacterized protein C4orf45"
FT /id="PRO_0000325755"
FT REGION 163..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 46
FT /note="A -> V (in dbSNP:rs17037864)"
FT /id="VAR_039901"
FT VARIANT 75
FT /note="S -> G (in dbSNP:rs662473)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_039902"
FT VARIANT 84
FT /note="Y -> C (in dbSNP:rs17037858)"
FT /id="VAR_039903"
FT VARIANT 93
FT /note="G -> E (in dbSNP:rs619128)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_039904"
FT VARIANT 134
FT /note="R -> H (in dbSNP:rs10517695)"
FT /id="VAR_039905"
FT CONFLICT 72
FT /note="E -> K (in Ref. 1; BAB71665)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 186 AA; 21723 MW; 5DF02D604613DF2B CRC64;
MASVSYQKPT STTVGKQMIF TGPDYIKDYL PKIHQHTSYV GEQHLALEKT GDLRYLWRPA
SNRSLPAKYK HEYVSEIGWR IPQYNFINKS RLGSGFHIKY EELSQASLDS ITHRYQNPWQ
PKPHVLDMQG KQSRASFAWH MSAFEDTDQR NSKWAILVRQ CKSSLPRASK PPKLPKLPKK
EKKRKH
