CD046_HUMAN
ID CD046_HUMAN Reviewed; 113 AA.
AC Q504U0; B3KNH7;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2005, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Renal cancer differentiation gene 1 protein {ECO:0000303|PubMed:25059753};
GN Name=C4orf46; Synonyms=RCDG1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pancreas, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=25059753; DOI=10.3892/mmr.2014.2388;
RA Yu Z., Ni L., Chen D., Su Z., Yu W., Zhang Q., Wang Y., Li C., Gui Y.,
RA Lai Y.;
RT "Expression and clinical significance of RCDG1 in renal cell carcinoma: a
RT novel renal cancer-associated gene.";
RL Mol. Med. Report. 10:1583-1589(2014).
CC -!- INTERACTION:
CC Q504U0; Q9UL45: BLOC1S6; NbExp=3; IntAct=EBI-6657981, EBI-465781;
CC Q504U0; Q01850: CDR2; NbExp=7; IntAct=EBI-6657981, EBI-1181367;
CC Q504U0; Q86X02: CDR2L; NbExp=8; IntAct=EBI-6657981, EBI-11063830;
CC Q504U0; O75031: HSF2BP; NbExp=3; IntAct=EBI-6657981, EBI-7116203;
CC Q504U0; O60921: HUS1; NbExp=6; IntAct=EBI-6657981, EBI-1056174;
CC Q504U0; Q9BQD3: KXD1; NbExp=6; IntAct=EBI-6657981, EBI-739657;
CC Q504U0; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-6657981, EBI-79165;
CC Q504U0; P0C1Z6-2: TFPT; NbExp=3; IntAct=EBI-6657981, EBI-10178002;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25059753}.
CC -!- TISSUE SPECIFICITY: Expressed in the kidney, in epithelial cells in
CC both proximal tubules and distal convoluted tubules.
CC {ECO:0000269|PubMed:25059753}.
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DR EMBL; AK027539; BAG51339.1; -; mRNA.
DR EMBL; AK074948; BAG52038.1; -; mRNA.
DR EMBL; CH471056; EAX04855.1; -; Genomic_DNA.
DR EMBL; BC065017; AAH65017.1; -; mRNA.
DR EMBL; BC094775; AAH94775.1; -; mRNA.
DR CCDS; CCDS34088.1; -.
DR RefSeq; NP_001008394.1; NM_001008393.3.
DR AlphaFoldDB; Q504U0; -.
DR SMR; Q504U0; -.
DR BioGRID; 128401; 15.
DR IntAct; Q504U0; 10.
DR STRING; 9606.ENSP00000368503; -.
DR iPTMnet; Q504U0; -.
DR PhosphoSitePlus; Q504U0; -.
DR BioMuta; C4orf46; -.
DR DMDM; 74740214; -.
DR EPD; Q504U0; -.
DR MassIVE; Q504U0; -.
DR MaxQB; Q504U0; -.
DR PaxDb; Q504U0; -.
DR PeptideAtlas; Q504U0; -.
DR PRIDE; Q504U0; -.
DR ProteomicsDB; 62404; -.
DR Antibodypedia; 53666; 139 antibodies from 17 providers.
DR DNASU; 201725; -.
DR Ensembl; ENST00000379205.5; ENSP00000368503.4; ENSG00000205208.5.
DR GeneID; 201725; -.
DR KEGG; hsa:201725; -.
DR MANE-Select; ENST00000379205.5; ENSP00000368503.4; NM_001008393.4; NP_001008394.1.
DR UCSC; uc003iqa.4; human.
DR CTD; 201725; -.
DR DisGeNET; 201725; -.
DR GeneCards; C4orf46; -.
DR HGNC; HGNC:27320; C4orf46.
DR HPA; ENSG00000205208; Low tissue specificity.
DR MIM; 616210; gene.
DR neXtProt; NX_Q504U0; -.
DR OpenTargets; ENSG00000205208; -.
DR PharmGKB; PA162379968; -.
DR VEuPathDB; HostDB:ENSG00000205208; -.
DR eggNOG; ENOG502SUFC; Eukaryota.
DR GeneTree; ENSGT00390000003125; -.
DR HOGENOM; CLU_171943_0_0_1; -.
DR InParanoid; Q504U0; -.
DR OMA; FKCMENA; -.
DR OrthoDB; 1562931at2759; -.
DR PhylomeDB; Q504U0; -.
DR TreeFam; TF338687; -.
DR PathwayCommons; Q504U0; -.
DR SignaLink; Q504U0; -.
DR BioGRID-ORCS; 201725; 21 hits in 1049 CRISPR screens.
DR ChiTaRS; C4orf46; human.
DR GenomeRNAi; 201725; -.
DR Pharos; Q504U0; Tdark.
DR PRO; PR:Q504U0; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q504U0; protein.
DR Bgee; ENSG00000205208; Expressed in buccal mucosa cell and 142 other tissues.
DR ExpressionAtlas; Q504U0; baseline and differential.
DR Genevisible; Q504U0; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR InterPro; IPR031457; RCDG1.
DR PANTHER; PTHR31641; PTHR31641; 1.
DR Pfam; PF15725; RCDG1; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Reference proteome.
FT CHAIN 1..113
FT /note="Renal cancer differentiation gene 1 protein"
FT /id="PRO_0000335689"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 113 AA; 11899 MW; 6FE4325ED2C2CAB2 CRC64;
MADPEELQVS SPPPPPPSSP SSSDASAASS PGGPVSLGWP VPSRSSGPTV DQLEEVELQI
GDAAFSLTKL LEATSAVSAQ VEELAFKCTE NARFLKTWRD LLKEGYDSLK PDD
