ID   CD047_HUMAN             Reviewed;         309 AA.
AC   A7E2U8; Q5BLP7;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=UPF0602 protein C4orf47;
GN   Name=C4orf47; ORFNames=Chr4_1746;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 38-129, AND TISSUE SPECIFICITY.
RX   PubMed=15809229; DOI=10.1093/nar/gki328;
RA   Castelo R., Reymond A., Wyss C., Camara F., Parra G., Antonarakis S.E.,
RA   Guigo R., Eyras E.;
RT   "Comparative gene finding in chicken indicates that we are closing in on
RT   the set of multi-exonic widely expressed human genes.";
RL   Nucleic Acids Res. 33:1935-1939(2005).
RN   [3]
RP   SUBCELLULAR LOCATION.
RX   PubMed=25074808; DOI=10.1242/jcs.157008;
RA   Firat-Karalar E.N., Sante J., Elliott S., Stearns T.;
RT   "Proteomic analysis of mammalian sperm cells identifies new components of
RT   the centrosome.";
RL   J. Cell Sci. 127:4128-4133(2014).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000269|PubMed:25074808}.
CC   -!- TISSUE SPECIFICITY: Detected in testis and fetal liver.
CC       {ECO:0000269|PubMed:15809229}.
CC   -!- SIMILARITY: Belongs to the UPF0602 family. {ECO:0000305}.
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DR   EMBL; BC150574; AAI50575.1; -; mRNA.
DR   EMBL; AY947525; AAX21786.1; -; mRNA.
DR   CCDS; CCDS47169.1; -.
DR   RefSeq; NP_001107829.1; NM_001114357.2.
DR   RefSeq; XP_005263076.1; XM_005263019.3.
DR   RefSeq; XP_011530291.1; XM_011531989.2.
DR   RefSeq; XP_016863725.1; XM_017008236.1.
DR   RefSeq; XP_016863726.1; XM_017008237.1.
DR   RefSeq; XP_016863727.1; XM_017008238.1.
DR   RefSeq; XP_016863728.1; XM_017008239.1.
DR   RefSeq; XP_016863729.1; XM_017008240.1.
DR   AlphaFoldDB; A7E2U8; -.
DR   BioGRID; 137120; 6.
DR   IntAct; A7E2U8; 1.
DR   STRING; 9606.ENSP00000368127; -.
DR   iPTMnet; A7E2U8; -.
DR   PhosphoSitePlus; A7E2U8; -.
DR   BioMuta; C4orf47; -.
DR   jPOST; A7E2U8; -.
DR   MassIVE; A7E2U8; -.
DR   PaxDb; A7E2U8; -.
DR   PeptideAtlas; A7E2U8; -.
DR   PRIDE; A7E2U8; -.
DR   ProteomicsDB; 1796; -.
DR   Antibodypedia; 52303; 21 antibodies from 11 providers.
DR   DNASU; 441054; -.
DR   Ensembl; ENST00000378850.5; ENSP00000368127.4; ENSG00000205129.9.
DR   GeneID; 441054; -.
DR   KEGG; hsa:441054; -.
DR   MANE-Select; ENST00000378850.5; ENSP00000368127.4; NM_001114357.3; NP_001107829.1.
DR   UCSC; uc003ixt.3; human.
DR   CTD; 441054; -.
DR   DisGeNET; 441054; -.
DR   GeneCards; C4orf47; -.
DR   HGNC; HGNC:34346; C4orf47.
DR   HPA; ENSG00000205129; Tissue enhanced (choroid plexus, fallopian tube, retina, testis).
DR   MalaCards; C4orf47; -.
DR   neXtProt; NX_A7E2U8; -.
DR   OpenTargets; ENSG00000205129; -.
DR   PharmGKB; PA162379983; -.
DR   VEuPathDB; HostDB:ENSG00000205129; -.
DR   eggNOG; ENOG502QVET; Eukaryota.
DR   GeneTree; ENSGT00390000010980; -.
DR   HOGENOM; CLU_078899_0_0_1; -.
DR   InParanoid; A7E2U8; -.
DR   OMA; YMMEEAK; -.
DR   OrthoDB; 1015843at2759; -.
DR   PhylomeDB; A7E2U8; -.
DR   TreeFam; TF329198; -.
DR   PathwayCommons; A7E2U8; -.
DR   SignaLink; A7E2U8; -.
DR   BioGRID-ORCS; 441054; 11 hits in 1039 CRISPR screens.
DR   ChiTaRS; C4orf47; human.
DR   GenomeRNAi; 441054; -.
DR   Pharos; A7E2U8; Tdark.
DR   PRO; PR:A7E2U8; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   RNAct; A7E2U8; protein.
DR   Bgee; ENSG00000205129; Expressed in oocyte and 128 other tissues.
DR   ExpressionAtlas; A7E2U8; baseline and differential.
DR   Genevisible; A7E2U8; HS.
DR   GO; GO:0097731; C:9+0 non-motile cilium; IDA:GO_Central.
DR   GO; GO:0005813; C:centrosome; IDA:UniProtKB.
DR   GO; GO:0005881; C:cytoplasmic microtubule; IDA:GO_Central.
DR   InterPro; IPR029358; DUF4586.
DR   PANTHER; PTHR31144; PTHR31144; 1.
DR   Pfam; PF15239; DUF4586; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..309
FT                   /note="UPF0602 protein C4orf47"
FT                   /id="PRO_0000341950"
FT   REGION          220..249
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   309 AA;  34376 MW;  E47AA27E6FDFFAA0 CRC64;
     MPAEGGKTDM ERIGLFSEME YITVGDKYVS QFNRPFNEAA SKNKQMLPGG SKEMSDLQAG
     YFDPHFVRIF EGEGYINLNQ VRRRDMVEAA KKNLGKAFLP SNGEKKPCGL GSYYGTIGGP
     VPFFSAQSKP REKYKAPGKN LYTNPGKKGT GYGYANITIG KQFSHSADFY DAAKLKYKKA
     NEEHHRLLKG APFKLNLHPR DYFDANPYFS EESLPPIKKE EKKKTISNTF KPSSPGKKPG
     GMKAGTFDPY PSHSADPYVA KLANISGKDD KIFHPPSGPK SRPVESIMTL NVRRALNSKN
     YKTSSVPSY