CD048_MOUSE
ID CD048_MOUSE Reviewed; 90 AA.
AC Q3UR78; B9EJP7; Q3V2U0;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 2.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Neuropeptide-like protein C4orf48 homolog;
DE Flags: Precursor;
GN Name=Gm1673;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND PARTIAL NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP ALTERNATIVE SPLICING (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RX PubMed=21287218; DOI=10.1007/s10048-011-0275-8;
RA Endele S., Nelkenbrecher C., Bordlein A., Schlickum S., Winterpacht A.;
RT "C4ORF48, a gene from the Wolf-Hirschhorn syndrome critical region, encodes
RT a putative neuropeptide and is expressed during neocortex and cerebellar
RT development.";
RL Neurogenetics 12:155-163(2011).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q3UR78-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3UR78-2; Sequence=VSP_034397;
CC -!- TISSUE SPECIFICITY: Specifically expressed during neocortex and
CC cerebellum development. {ECO:0000269|PubMed:21287218}.
CC -!- DEVELOPMENTAL STAGE: First expressed in the cerebral cortex after the
CC preplate stage (>E12). At embryonic stage 15.5 dpc and up to 17.5 dpc,
CC it is expressed in cortical plate and in the marginal zone, whereas in
CC adult brain, it is present in all cortical and subcortical regions of
CC the brain. In the developing cerebellum, expressed in the intermediate
CC zone at stage 17.5 dpc, in the molecular layer in newborn, and in the
CC granular as well as molecular layer in adult. In the adult brain,
CC expression in interneurons is also observed.
CC {ECO:0000269|PubMed:21287218}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI47445.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI47469.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAE24810.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK131594; BAE20707.1; -; mRNA.
DR EMBL; AK141724; BAE24810.1; ALT_INIT; mRNA.
DR EMBL; BC147444; AAI47445.1; ALT_INIT; mRNA.
DR EMBL; BC147468; AAI47469.1; ALT_INIT; mRNA.
DR CCDS; CCDS19209.2; -. [Q3UR78-1]
DR CCDS; CCDS80261.1; -. [Q3UR78-1]
DR RefSeq; NP_001028630.2; NM_001033458.4. [Q3UR78-2]
DR RefSeq; NP_001297475.1; NM_001310546.1. [Q3UR78-1]
DR RefSeq; NP_001297476.1; NM_001310547.1. [Q3UR78-1]
DR AlphaFoldDB; Q3UR78; -.
DR STRING; 10090.ENSMUSP00000092467; -.
DR PaxDb; Q3UR78; -.
DR PRIDE; Q3UR78; -.
DR ProteomicsDB; 279960; -. [Q3UR78-1]
DR ProteomicsDB; 279961; -. [Q3UR78-2]
DR Antibodypedia; 64905; 5 antibodies from 5 providers.
DR Ensembl; ENSMUST00000094869; ENSMUSP00000092467; ENSMUSG00000070858. [Q3UR78-2]
DR Ensembl; ENSMUST00000114382; ENSMUSP00000110024; ENSMUSG00000070858. [Q3UR78-1]
DR Ensembl; ENSMUST00000114383; ENSMUSP00000110025; ENSMUSG00000070858. [Q3UR78-1]
DR GeneID; 381633; -.
DR KEGG; mmu:381633; -.
DR UCSC; uc008xbp.1; mouse. [Q3UR78-1]
DR UCSC; uc008xbr.1; mouse. [Q3UR78-2]
DR MGI; MGI:2686519; Gm1673.
DR VEuPathDB; HostDB:ENSMUSG00000070858; -.
DR eggNOG; ENOG502S5WR; Eukaryota.
DR GeneTree; ENSGT00390000013043; -.
DR HOGENOM; CLU_153985_0_0_1; -.
DR InParanoid; Q3UR78; -.
DR OrthoDB; 1556209at2759; -.
DR PhylomeDB; Q3UR78; -.
DR TreeFam; TF336171; -.
DR BioGRID-ORCS; 381633; 1 hit in 67 CRISPR screens.
DR ChiTaRS; Gm1673; mouse.
DR PRO; PR:Q3UR78; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q3UR78; protein.
DR Bgee; ENSMUSG00000070858; Expressed in embryonic brain and 152 other tissues.
DR ExpressionAtlas; Q3UR78; baseline and differential.
DR Genevisible; Q3UR78; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR028147; Neuropep-like.
DR PANTHER; PTHR35451; PTHR35451; 1.
DR Pfam; PF15161; Neuropep_like; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; Secreted; Signal.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..90
FT /note="Neuropeptide-like protein C4orf48 homolog"
FT /id="PRO_0000342195"
FT VAR_SEQ 1
FT /note="M -> MTTTSGGPGWGRLGRMRARAGRGRSSRVARAACSRFLEPRAAWAPSA
FT M (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034397"
SQ SEQUENCE 90 AA; 9806 MW; FC5869583AD637E2 CRC64;
MAPALRSLLS PRTLLLLLLS LALLGARAEP ATGSAVPAQS RPCVDCHAFE FMQRALQDLR
KTAYSLDART ETLLLQAERR ALCACWPAGR