CD050_HUMAN
ID CD050_HUMAN Reviewed; 276 AA.
AC Q6ZRC1;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Uncharacterized protein C4orf50;
GN Name=C4orf50;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thymus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP VARIANT [LARGE SCALE ANALYSIS] PRO-150.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
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DR EMBL; AK128339; BAC87391.1; -; mRNA.
DR AlphaFoldDB; Q6ZRC1; -.
DR SMR; Q6ZRC1; -.
DR IntAct; Q6ZRC1; 1.
DR iPTMnet; Q6ZRC1; -.
DR PhosphoSitePlus; Q6ZRC1; -.
DR BioMuta; C4orf50; -.
DR DMDM; 74711113; -.
DR PaxDb; Q6ZRC1; -.
DR PeptideAtlas; Q6ZRC1; -.
DR PRIDE; Q6ZRC1; -.
DR Antibodypedia; 71691; 10 antibodies from 8 providers.
DR Ensembl; ENST00000324058.9; ENSP00000317287.5; ENSG00000181215.15.
DR UCSC; uc062uxv.1; human.
DR GeneCards; C4orf50; -.
DR HGNC; HGNC:33766; C4orf50.
DR HPA; ENSG00000181215; Tissue enriched (brain).
DR neXtProt; NX_Q6ZRC1; -.
DR OpenTargets; ENSG00000181215; -.
DR VEuPathDB; HostDB:ENSG00000181215; -.
DR eggNOG; ENOG502S96Q; Eukaryota.
DR GeneTree; ENSGT00390000003220; -.
DR HOGENOM; CLU_1024990_0_0_1; -.
DR InParanoid; Q6ZRC1; -.
DR OMA; WIFQDME; -.
DR PhylomeDB; Q6ZRC1; -.
DR PathwayCommons; Q6ZRC1; -.
DR SignaLink; Q6ZRC1; -.
DR ChiTaRS; C4orf50; human.
DR Pharos; Q6ZRC1; Tdark.
DR PRO; PR:Q6ZRC1; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q6ZRC1; protein.
DR Bgee; ENSG00000181215; Expressed in nucleus accumbens and 35 other tissues.
DR ExpressionAtlas; Q6ZRC1; baseline and differential.
DR InterPro; IPR032771; DUF4527.
DR Pfam; PF15030; DUF4527; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..276
FT /note="Uncharacterized protein C4orf50"
FT /id="PRO_0000329449"
FT COILED 37..72
FT /evidence="ECO:0000255"
FT VARIANT 86
FT /note="R -> W (in dbSNP:rs16837960)"
FT /id="VAR_042680"
FT VARIANT 150
FT /note="A -> P (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_042681"
FT VARIANT 177
FT /note="I -> V (in dbSNP:rs6839295)"
FT /id="VAR_042682"
FT VARIANT 199
FT /note="V -> M (in dbSNP:rs7695618)"
FT /id="VAR_042683"
SQ SEQUENCE 276 AA; 30622 MW; 1C072E76576E7A7D CRC64;
MLRDSEAEVT EEDPRLRAQQ LHHRVLTLQC QLRDQGAAHQ ASLDEATRLQ EELQAKLEEL
QKKQHEAKLA VTPLKAKIAS LVRKCRERNR LITHLLQELH RHGLGNLLLS ELAQNMLNDV
ALAEYTATFL APGVPETSHH LDVKSEMTAA LRAQTYLLNP EMDSVLQSSL SSESWPIPEP
EWPAQTAQLD SLKLPLSLVS TLDPGTCLAA VTVEPGLPAQ RLQEKGGMPC PALQVDNVPA
PSELLSPARI LAFHQELRQS ICSNSQVHKS PLELEM
