CD054_MOUSE
ID CD054_MOUSE Reviewed; 1786 AA.
AC E0CYV9;
DT 25-APR-2018, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 1.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=Uncharacterized protein C4orf54 homolog {ECO:0000305};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-721 AND SER-1179, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, and Heart;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-1767, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, and Embryo;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
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DR EMBL; AC131122; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS89691.1; -.
DR RefSeq; XP_006502617.1; XM_006502554.1.
DR AlphaFoldDB; E0CYV9; -.
DR iPTMnet; E0CYV9; -.
DR PhosphoSitePlus; E0CYV9; -.
DR MaxQB; E0CYV9; -.
DR PaxDb; E0CYV9; -.
DR PRIDE; E0CYV9; -.
DR ProteomicsDB; 322615; -.
DR Ensembl; ENSMUST00000163080; ENSMUSP00000123851; ENSMUSG00000090066.
DR MGI; MGI:1915066; 1110002E22Rik.
DR VEuPathDB; HostDB:ENSMUSG00000090066; -.
DR eggNOG; ENOG502QW5W; Eukaryota.
DR GeneTree; ENSGT00730000111645; -.
DR HOGENOM; CLU_003127_0_0_1; -.
DR InParanoid; E0CYV9; -.
DR OMA; IYHQPPL; -.
DR OrthoDB; 231950at2759; -.
DR TreeFam; TF343894; -.
DR PRO; PR:E0CYV9; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; E0CYV9; protein.
DR Bgee; ENSMUSG00000090066; Expressed in gastrocnemius medialis and 119 other tissues.
DR InterPro; IPR027838; DUF4585.
DR Pfam; PF15232; DUF4585; 1.
PE 1: Evidence at protein level;
KW Methylation; Phosphoprotein; Reference proteome.
FT CHAIN 1..1786
FT /note="Uncharacterized protein C4orf54 homolog"
FT /id="PRO_0000444030"
FT REGION 140..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 400..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 746..907
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1081..1180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1218..1242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1291..1348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1362..1460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1477..1550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..274
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..304
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..329
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 416..437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..465
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 746..806
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 807..832
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 884..906
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1081..1108
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1110..1124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1222..1242
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1307..1321
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1334..1348
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1388..1404
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1488..1525
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 721
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1179
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1767
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
SQ SEQUENCE 1786 AA; 189749 MW; 6B4F132CF0440B96 CRC64;
MLSVHFWQTP VRPTDAASSL ANGIQTPTHR RCQTSNWTGQ LSSRTLATIA ARAAAPWLQT
TSAASFGSPP TSLWLAEAPP QGLKNWAVVA TVAVVPTALG PAQARGNLFQ ATLWPLRDQR
GTQDSPSAHH CLILSLKPGQ GLRMEGGTSD MNSQTSLTPA EDPVSRPQDS PEPRQQLRPL
PEPSASTLPE AKYVETCASA GLRRESPQTL KLPPEQQASR SPKTKAQDEP SGHAPEAPAP
GESPASSQCL PSQACENDFS SSSSSSSSLV DSAEDNGLSK MDDPTKLLGV LATSSSSLGF
ESDPETSCRQ HREEAGDRAG AGEDKRGGVD DGIASCKDII AKSHSKRGPL RNEDAHYITT
HEIQLTEVEQ GMDFDVGLAS RWDFEDNNVI YSFVDYASFG GSDETPGDIT TEEDDDNSCY
VSTTPSTNTT RTPSPISSDL ARPGAGSSGR DTSSTEVGSG PSDSDTVPPP TGPGTATPPE
PLLELREAAL GASATAASSC GSAASQILLS IKPTSRAINE PSNVRAKQNI IYAAKHEGDM
SLRVSSAAEH NSSSLKQNSA AAVAQDHAKK FIAVPARLQT RCGAIRAKEL VDYASGASSA
VSELDDADKE VRNLTSRAFR SLAYPYFEAL NISSRESSTT LSEVGFGRWS TFLDLKCGGV
GARVEQSLLR SSAASVAAGL RKGGGTRATA DQLYLQTKKS QTKALEFVVS KVEGEIKHVE
TPLCFQKQVQ TGSRVVTLLE PLNLRSESKA SSATGPCRIT KGSSKGPGSV YTDDGSETSE
SSKPASRSDG PQKKSKFASS LLKNVISKKM QREHEFKMER GEVTDTSHRN PPSTKETEGP
PGAEKPWERG LQRQSSRHSE ASSEYTVVSV SDAGGEGSVV GSKSPIFKAS TPRESHTGSG
QNVSDGHTEV CEIKKSASET VKGIFLRSQN SAFRTWKEKE AEKLEEKAPV GRLKLRKGGD
WRADLGEISA SKSTIMSRLF VPNIQQTPKD KQPEKQATKY PAAAAQATSV AVIRPKAPEI
KIRLGSVQQP SSDFNIAKLL TPKLASGSSS KLFKTIEDNS RTQQKLFRGG DNLEKVPQFQ
VRDVRDKSKA SGPLHQVRDV RKLIKGSGDS SDKGSVTPEQ GLTGPKPRQL TPASGGSRSL
SPMVIMCQAV ANPREEGVDR EPREGVSQVS NGGRLLNSSP EGTVLVHRAS GRLPVATIAP
NKSEQGSYLP VLKIVSKASA QRTPEKPKEE EAKEEGKAPK PARNALEKLT AAVRSMEELY
SFNRNEWKRK SDPLPMMADS HVLSLIASEE KEGVAGPEGG DPDKLAKQLG QVEERDTGHK
GGVVLRAAPI ERLQRRNSNP STESVSARAA AFENMARERP RSLYIPPVHK DVERTQPLQP
LPPLPGNRNV FTVSSSSTQK TGGVAGKFPQ GPSPEGLSTA KGIKAQGLRS LKISPATRAP
PEDASNRKTA VSLEKSNSDC ENYLTIPLKG SAASAELLGR PGASRDGPPS SSAATLCSLP
PLSARSQVPS NPKGSQVSGT SRPAWRTKPD NHRETVVAAP TGPQSPEHTP TAVYHQQALP
FTLQGAQPQV LCFSPPGMPA PAPAGPAAVP TDPFQQPQPQ QTQRKMLLDV TTGQYYLVDT
PVQPMTRRLF DPETGQYVDV PMTSQQQPVA PMSLPVPPLA LSPGAYGPTY MIYPGFLPTV
LPPNALQPTP MAHTPGGSEL SVATEPPSKE TAAAFTEAPY FMASSQSPAS SSSSAPAATP
QLVGAKGFAQ LHGKPVISIT SQPLGPRIIA PPSFDGTTMS FVVEHR
