ID   CD123_AJECN             Reviewed;         424 AA.
AC   A6R687;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Cell division cycle protein 123;
GN   Name=CDC123; ORFNames=HCAG_05145;
OS   Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma;
OC   unclassified Histoplasma.
OX   NCBI_TaxID=2059318;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NAm1 / WU24;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- FUNCTION: Regulates the cell cycle in a nutrient dependent manner.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CDC123 family. {ECO:0000305}.
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DR   EMBL; CH476659; EDN08646.1; -; Genomic_DNA.
DR   RefSeq; XP_001539678.1; XM_001539628.1.
DR   AlphaFoldDB; A6R687; -.
DR   SMR; A6R687; -.
DR   STRING; 339724.A6R687; -.
DR   PRIDE; A6R687; -.
DR   EnsemblFungi; EDN08646; EDN08646; HCAG_05145.
DR   GeneID; 5445886; -.
DR   KEGG; aje:HCAG_05145; -.
DR   VEuPathDB; FungiDB:HCAG_05145; -.
DR   HOGENOM; CLU_034402_2_0_1; -.
DR   OMA; RDLNHFD; -.
DR   OrthoDB; 1539674at2759; -.
DR   Proteomes; UP000009297; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   InterPro; IPR009772; CDC123.
DR   PANTHER; PTHR15323; PTHR15323; 1.
DR   Pfam; PF07065; D123; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cytoplasm; Reference proteome.
FT   CHAIN           1..424
FT                   /note="Cell division cycle protein 123"
FT                   /id="PRO_0000350934"
FT   REGION          64..95
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          325..351
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        81..95
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        325..339
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   424 AA;  48087 MW;  F5F80FBE7058DC92 CRC64;
     MAGNNNTPLG SSSGLPFPTL KRSHILHCSY HYWHPKYRSV TPKARLIPLN DAFLNYLRAD
     GIILPPQDEN PPGADDDSGI YSLSDDSDPD DDDVDPSIQW QEIHAQIKAT IEELGGKVAP
     KLNWSAPKDA TWISATNDMQ CRTPNDIYLL LKSSDFVTHD LEHAFDGCVS DTEEKSDGEV
     EVEVEEGKEK EQKQAEQSRI PYHLVLRKYI TLNPSLEFRC FVRDRKLLCL CQRDLNHFNF
     LFGLRDNLRD KIQTFFDIRL RDTFPDPDFV FDVYVPPPHN RVWLIDINPF ALRTDPLLFS
     WLEILNLKVP SCDDDGESDT VRVEMRRGGA ERGTENGIGD EESEGGDEDD LDAATTFSFV
     PEFRLVEHDD PEAYGFATPR YSAHKLPRDV VDASRSGPGG MNEFLGQWQD ILAKRIQEDE
     EGGA