ID   CD123_ASPNC             Reviewed;         371 AA.
AC   A2R4R1;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Cell division cycle protein 123;
GN   Name=cdc123; ORFNames=An15g01290;
OS   Aspergillus niger (strain CBS 513.88 / FGSC A1513).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=425011;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 513.88 / FGSC A1513 / ATCC MYA-4892;
RX   PubMed=17259976; DOI=10.1038/nbt1282;
RA   Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA   Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA   Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X.,
RA   Contreras R., Cornell M., Coutinho P.M., Danchin E.G.J., Debets A.J.M.,
RA   Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M.,
RA   d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J.,
RA   Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W.,
RA   van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M.,
RA   Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA   van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A.,
RA   Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E.,
RA   Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J.,
RA   Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H.,
RA   Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.;
RT   "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT   niger CBS 513.88.";
RL   Nat. Biotechnol. 25:221-231(2007).
CC   -!- FUNCTION: Regulates the cell cycle in a nutrient dependent manner.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CDC123 family. {ECO:0000305}.
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DR   EMBL; AM270336; CAL00943.1; -; Genomic_DNA.
DR   AlphaFoldDB; A2R4R1; -.
DR   SMR; A2R4R1; -.
DR   PaxDb; A2R4R1; -.
DR   EnsemblFungi; CAL00943; CAL00943; An15g01290.
DR   VEuPathDB; FungiDB:An15g01290; -.
DR   HOGENOM; CLU_034402_2_0_1; -.
DR   Proteomes; UP000006706; Chromosome 3R.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:EnsemblFungi.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:EnsemblFungi.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:1905143; P:eukaryotic translation initiation factor 2 complex assembly; IEA:EnsemblFungi.
DR   GO; GO:0045948; P:positive regulation of translational initiation; IEA:EnsemblFungi.
DR   InterPro; IPR009772; CDC123.
DR   PANTHER; PTHR15323; PTHR15323; 1.
DR   Pfam; PF07065; D123; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cytoplasm; Reference proteome.
FT   CHAIN           1..371
FT                   /note="Cell division cycle protein 123"
FT                   /id="PRO_0000350937"
FT   REGION          73..101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        84..99
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   371 AA;  42660 MW;  F8D3F2E378C93B2A CRC64;
     MPHIDSEAPA PAAEAPTEQL TRLPFPPVTY SHILHCSYHH WQPRYRTLVP KSRAIRLTAP
     FVKYLRADGI VLPPEAAPPT DDDNLDTFSD DGADEEPDPS VEWPEIHNQI KSTITEYGGK
     VTPKLNWSAP KDATWMSATN DTQCRTANDI YLLLKSSDFI SHDLEHPFDD CVSDTTTTDD
     SSSTPPEIPY YLVLRKYVNF NPSLEFRCFV RNRVLLCMCQ RDQNHFDFLF PMRDSLRSRI
     QTFFDEKLKD TFTDPNFVFD VYIPPPHDRV WLIDINPWAE RTDSLLFSWM EILHMKDPVD
     DAPLFPEFRL IKRDDPEAYA FTTPQYSAHK LPKEVVDASI SGPGGMSEFL GKWQDILAKQ
     AQESDSDNED Q