CD123_CANAL
ID CD123_CANAL Reviewed; 345 AA.
AC Q5AFX2; A0A1D8PLN5; Q5AF86;
DT 23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2017, sequence version 2.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Cell division cycle protein 123;
GN Name=CDC123; OrderedLocusNames=CAALFM_C402770CA;
GN ORFNames=CaO19.10236, CaO19.2721;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: Regulates the cell cycle in a nutrient dependent manner.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CDC123 family. {ECO:0000305}.
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DR EMBL; CP017626; AOW29044.1; -; Genomic_DNA.
DR RefSeq; XP_720471.2; XM_715378.2.
DR AlphaFoldDB; Q5AFX2; -.
DR SMR; Q5AFX2; -.
DR STRING; 237561.Q5AFX2; -.
DR GeneID; 3637903; -.
DR KEGG; cal:CAALFM_C402770CA; -.
DR CGD; CAL0000179097; orf19.10236.
DR VEuPathDB; FungiDB:C4_02770C_A; -.
DR eggNOG; KOG2983; Eukaryota.
DR HOGENOM; CLU_034402_2_0_1; -.
DR InParanoid; Q5AFX2; -.
DR OrthoDB; 1539674at2759; -.
DR PRO; PR:Q5AFX2; -.
DR Proteomes; UP000000559; Chromosome 4.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:1905143; P:eukaryotic translation initiation factor 2 complex assembly; IEA:EnsemblFungi.
DR GO; GO:0045948; P:positive regulation of translational initiation; IEA:EnsemblFungi.
DR InterPro; IPR009772; CDC123.
DR PANTHER; PTHR15323; PTHR15323; 1.
DR Pfam; PF07065; D123; 1.
DR PIRSF; PIRSF007807; Cdc123; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Cytoplasm; Reference proteome.
FT CHAIN 1..345
FT /note="Cell division cycle protein 123"
FT /id="PRO_0000350941"
SQ SEQUENCE 345 AA; 40106 MW; C58E2AD89A4D555B CRC64;
MTERDYTTFE TIDLTSEEVL QCSYSNWSKL FPGKTFPSKI IKPLPSTFLD YLASESIRLP
SNTNNKKITV LEADSDNEYS DWDDEEDQQQ DAEHNDNVFS QFQDIQDKID ASIQEMGGAV
FTKLNWSSPK DAKWIMPGNT IKCQNVSDVY LLLNSSDHIG DDLDNPFSEV QKKKTIPEKV
DYELVLTKWQ EINPAYEFRV FVKDHRIIGI SQRDNNKYEF LQGLKSELNE KITQFVEDHV
IPKLKSDTQL SKYIVDVYVS KNDIYIIDIN PFSRKSDSCL FTWVELLDKK DKHDNHHELR
LVENQNFAKE FSESQVPIEV VGATMDTEAM VELAREWDKL QAKEK
