ID   CD123_DANRE             Reviewed;         348 AA.
AC   Q6PC40;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Cell division cycle protein 123 homolog;
GN   Name=cdc123; ORFNames=zgc:73119;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo, and Retina;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for S phase entry of the cell cycle. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CDC123 family. {ECO:0000305}.
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DR   EMBL; BX323869; CAI11758.1; -; Genomic_DNA.
DR   EMBL; BC059483; AAH59483.1; -; mRNA.
DR   EMBL; BC071332; AAH71332.1; -; mRNA.
DR   RefSeq; NP_957015.1; NM_200721.1.
DR   AlphaFoldDB; Q6PC40; -.
DR   SMR; Q6PC40; -.
DR   STRING; 7955.ENSDARP00000103868; -.
DR   PaxDb; Q6PC40; -.
DR   Ensembl; ENSDART00000111986; ENSDARP00000103868; ENSDARG00000075025.
DR   GeneID; 393694; -.
DR   KEGG; dre:393694; -.
DR   CTD; 8872; -.
DR   ZFIN; ZDB-GENE-040426-1680; cdc123.
DR   eggNOG; KOG2983; Eukaryota.
DR   GeneTree; ENSGT00390000003057; -.
DR   HOGENOM; CLU_034402_0_0_1; -.
DR   InParanoid; Q6PC40; -.
DR   OMA; RDLNHFD; -.
DR   OrthoDB; 1539674at2759; -.
DR   PhylomeDB; Q6PC40; -.
DR   TreeFam; TF323348; -.
DR   PRO; PR:Q6PC40; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 4.
DR   Bgee; ENSDARG00000075025; Expressed in somite and 27 other tissues.
DR   ExpressionAtlas; Q6PC40; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   InterPro; IPR009772; CDC123.
DR   PANTHER; PTHR15323; PTHR15323; 1.
DR   Pfam; PF07065; D123; 1.
DR   PIRSF; PIRSF007807; Cdc123; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Cytoplasm; Reference proteome.
FT   CHAIN           1..348
FT                   /note="Cell division cycle protein 123 homolog"
FT                   /id="PRO_0000228666"
FT   REGION          49..68
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        49..64
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   348 AA;  39887 MW;  FE50DED69426C2D3 CRC64;
     MKKEQVVNCQ FSVWYPLFKK HTIKSLILPI PQNVIDYLLD DGTLVVSGSE NNNSQTQANN
     SDSDEEDIQW TDDETTTTVT APEFPEFNVK VQEAINVLGG CIFPKLNWSA PRDANWIALN
     SSLQCQSLSE IFLLFKSSDF ITHDLTQPFL HCSDDSPDPT INYELVLRKW SELIPGGEFR
     CFVKENKLIA ICQRDYTQHY QHIGKQEASI STSILQFFRD NIQYQFPDED FVLDVYRDSS
     GRVWLIDFNP FGEVTDSLLF TWEELTSGKN LTANQTQEET ALPDGPAFRC TNSEVTVQPS
     PCLSYRIPRD FLDLTTGEDA YKLIDFLKLK RGQQEEEEES NEEGEEPQ