ID   CD123_DICDI             Reviewed;         384 AA.
AC   Q75JF9; Q552G1;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Cell division cycle protein 123 homolog;
GN   Name=cdc123; ORFNames=DDB_G0276129;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Required for S phase entry of the cell cycle. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CDC123 family. {ECO:0000305}.
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DR   EMBL; AAFI02000014; EAL69364.1; -; Genomic_DNA.
DR   RefSeq; XP_643249.1; XM_638157.1.
DR   AlphaFoldDB; Q75JF9; -.
DR   SMR; Q75JF9; -.
DR   STRING; 44689.DDB0266706; -.
DR   PaxDb; Q75JF9; -.
DR   EnsemblProtists; EAL69364; EAL69364; DDB_G0276129.
DR   GeneID; 8620292; -.
DR   KEGG; ddi:DDB_G0276129; -.
DR   dictyBase; DDB_G0276129; cdc123.
DR   eggNOG; KOG2983; Eukaryota.
DR   HOGENOM; CLU_034402_2_0_1; -.
DR   InParanoid; Q75JF9; -.
DR   OMA; RDLNHFD; -.
DR   PhylomeDB; Q75JF9; -.
DR   PRO; PR:Q75JF9; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   InterPro; IPR009772; CDC123.
DR   PANTHER; PTHR15323; PTHR15323; 1.
DR   Pfam; PF07065; D123; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cytoplasm; Reference proteome.
FT   CHAIN           1..384
FT                   /note="Cell division cycle protein 123 homolog"
FT                   /id="PRO_0000331560"
FT   REGION          90..115
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   384 AA;  45038 MW;  0733A103BEEA8133 CRC64;
     MEKHDIKYFE NKKQCQFQEW YEKFKSVTFS SIVIPLPKIF IDYLQSDQFT TPHEGFPEFK
     VDEHDDLFDD NNWSTSKNHI STLDPKYYQG YSDEEDESSD DDDSNDNDKD KKPKRIVNET
     EFKELSNQII KSIEKLGGNI FPKLNWSSPK DASWMNVYNS LKCTNTTDIY LLLKSSDFIN
     HDLMQFSINQ DDKDDSLTPY VLVLRKWQNL QPSMEFRCFV KDNQLLGISQ RDISTYFKFL
     KDKKQKIQDA IVKFYNESIC GKFSNNSFTF DCYVTKDEQV WLIDFNPIHP STEALLFVWD
     ELIPELIEQD QDEKENEETK QAKEELPIEP LTKLEFRIID DESGIKPNLA MTSRLPLDLL
     QSSGGTGQGN INDILLNFKN QNLN