CD123_EMENI
ID CD123_EMENI Reviewed; 407 AA.
AC Q5AYN6; C8V129;
DT 23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 79.
DE RecName: Full=Cell division cycle protein 123;
GN Name=cdc123; ORFNames=AN6594;
OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS M139) (Aspergillus nidulans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=227321;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=16372000; DOI=10.1038/nature04341;
RA Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT fumigatus and A. oryzae.";
RL Nature 438:1105-1115(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA Oliver S.G., Turner G.;
RT "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT effort.";
RL Fungal Genet. Biol. 46:S2-13(2009).
CC -!- FUNCTION: Regulates the cell cycle in a nutrient dependent manner.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CDC123 family. {ECO:0000305}.
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DR EMBL; AACD01000110; EAA58123.1; -; Genomic_DNA.
DR EMBL; BN001301; CBF71058.1; -; Genomic_DNA.
DR RefSeq; XP_664198.1; XM_659106.1.
DR AlphaFoldDB; Q5AYN6; -.
DR SMR; Q5AYN6; -.
DR STRING; 162425.CADANIAP00007372; -.
DR EnsemblFungi; CBF71058; CBF71058; ANIA_06594.
DR EnsemblFungi; EAA58123; EAA58123; AN6594.2.
DR GeneID; 2870661; -.
DR KEGG; ani:AN6594.2; -.
DR VEuPathDB; FungiDB:AN6594; -.
DR eggNOG; KOG2983; Eukaryota.
DR HOGENOM; CLU_034402_2_0_1; -.
DR InParanoid; Q5AYN6; -.
DR OMA; RDLNHFD; -.
DR OrthoDB; 1539674at2759; -.
DR Proteomes; UP000000560; Chromosome I.
DR Proteomes; UP000005890; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:EnsemblFungi.
DR GO; GO:0000287; F:magnesium ion binding; IEA:EnsemblFungi.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:1905143; P:eukaryotic translation initiation factor 2 complex assembly; IEA:EnsemblFungi.
DR GO; GO:0045948; P:positive regulation of translational initiation; IEA:EnsemblFungi.
DR InterPro; IPR009772; CDC123.
DR PANTHER; PTHR15323; PTHR15323; 1.
DR Pfam; PF07065; D123; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Cytoplasm; Reference proteome.
FT CHAIN 1..407
FT /note="Cell division cycle protein 123"
FT /id="PRO_0000350943"
FT REGION 68..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 312..346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 374..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..94
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 407 AA; 46623 MW; 4834F41AC41AE4D2 CRC64;
MPLIESDATG SPTDQLQRLP FPPVTYSHIL HCSYDYWQPK YRALTPKSRI IPLTSSFVSY
LHADGIVLPP ENTPPTNDDD DFSDDPDAEE EADPSKDWPE VHAQIKSAIA ELDGKVTPKL
NWSAPKDATW MAATNDLQCR TPNDIYLLLK SSDFITHDLE HPFDDCVPDT SYSPAPISTP
PEVKYNLVLR KYVNFNPSLE FRCFVRNRIL LCICQRDQNH FDFLFELRDT LRSRIQSFFD
EKLKDSFPDS SFVFDVYIPA PHQRVWLIDI NPWAERTDPL LFSWLEILRM KDPIGIQEED
DSAEEQFVRL SLNGHSNGDQ KPESESESEE EVEKAEDDAP LLPEFRLVKR DDPEAYSFTT
PQYSAHKLPK EVVDASMTGP GGMSEFLGQW QDILSRQGQE SDTESDN
