CD123_HUMAN
ID CD123_HUMAN Reviewed; 336 AA.
AC O75794; A8JZZ7; Q14107; Q5T0L4; Q5T0L5; Q5T0L7; Q5T0L8; Q5T0L9;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Cell division cycle protein 123 homolog;
DE Short=Protein D123;
DE AltName: Full=HT-1080;
DE AltName: Full=PZ32;
GN Name=CDC123; Synonyms=C10orf7, D123;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Foreskin;
RX PubMed=8601400; DOI=10.1006/excr.1996.0078;
RA Okuda A., Kimura G.;
RT "An amino acid change in novel protein D123 is responsible for temperature-
RT sensitive G1-phase arrest in a mutant of rat fibroblast line 3Y1.";
RL Exp. Cell Res. 223:242-249(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Fibrosarcoma;
RX PubMed=9683532; DOI=10.1006/excr.1998.4074;
RA Onisto M., Zeilante P., Scannapieco P., Pellati D., Pozza M., Caenazzo C.,
RA Negro A., Garbisa S.;
RT "Expression study on D123 gene product: evidence for high positivity in
RT testis.";
RL Exp. Cell Res. 242:451-459(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Bone marrow, and Lymph;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- FUNCTION: Required for S phase entry of the cell cycle. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Widely expressed. Expressed in spleen, thymus,
CC prostate, testis, ovary, small intestine, colon and leukocytes with the
CC highest expression in testis. {ECO:0000269|PubMed:9683532}.
CC -!- SIMILARITY: Belongs to the CDC123 family. {ECO:0000305}.
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DR EMBL; D14878; BAA03593.1; -; mRNA.
DR EMBL; U27112; AAC34738.1; -; mRNA.
DR EMBL; CR456966; CAG33247.1; -; mRNA.
DR EMBL; AK289362; BAF82051.1; -; mRNA.
DR EMBL; AL512770; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471072; EAW86317.1; -; Genomic_DNA.
DR EMBL; BC001600; AAH01600.1; -; mRNA.
DR EMBL; BC009598; AAH09598.1; -; mRNA.
DR CCDS; CCDS7090.1; -.
DR RefSeq; NP_006014.2; NM_006023.2.
DR AlphaFoldDB; O75794; -.
DR SMR; O75794; -.
DR BioGRID; 114392; 45.
DR IntAct; O75794; 15.
DR MINT; O75794; -.
DR STRING; 9606.ENSP00000281141; -.
DR GlyGen; O75794; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; O75794; -.
DR PhosphoSitePlus; O75794; -.
DR SwissPalm; O75794; -.
DR BioMuta; CDC123; -.
DR EPD; O75794; -.
DR jPOST; O75794; -.
DR MassIVE; O75794; -.
DR MaxQB; O75794; -.
DR PaxDb; O75794; -.
DR PeptideAtlas; O75794; -.
DR PRIDE; O75794; -.
DR ProteomicsDB; 50198; -.
DR Antibodypedia; 24692; 425 antibodies from 31 providers.
DR DNASU; 8872; -.
DR Ensembl; ENST00000281141.9; ENSP00000281141.4; ENSG00000151465.14.
DR GeneID; 8872; -.
DR KEGG; hsa:8872; -.
DR MANE-Select; ENST00000281141.9; ENSP00000281141.4; NM_006023.3; NP_006014.2.
DR UCSC; uc001ill.4; human.
DR CTD; 8872; -.
DR DisGeNET; 8872; -.
DR GeneCards; CDC123; -.
DR HGNC; HGNC:16827; CDC123.
DR HPA; ENSG00000151465; Low tissue specificity.
DR MIM; 617708; gene.
DR neXtProt; NX_O75794; -.
DR OpenTargets; ENSG00000151465; -.
DR PharmGKB; PA162382148; -.
DR VEuPathDB; HostDB:ENSG00000151465; -.
DR eggNOG; KOG2983; Eukaryota.
DR GeneTree; ENSGT00390000003057; -.
DR InParanoid; O75794; -.
DR OMA; RDLNHFD; -.
DR OrthoDB; 1539674at2759; -.
DR PhylomeDB; O75794; -.
DR TreeFam; TF323348; -.
DR PathwayCommons; O75794; -.
DR SignaLink; O75794; -.
DR BioGRID-ORCS; 8872; 806 hits in 1064 CRISPR screens.
DR ChiTaRS; CDC123; human.
DR GeneWiki; CDC123; -.
DR GenomeRNAi; 8872; -.
DR Pharos; O75794; Tbio.
DR PRO; PR:O75794; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; O75794; protein.
DR Bgee; ENSG00000151465; Expressed in rectum and 210 other tissues.
DR ExpressionAtlas; O75794; baseline and differential.
DR Genevisible; O75794; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:1905143; P:eukaryotic translation initiation factor 2 complex assembly; ISS:BHF-UCL.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; TAS:ProtInc.
DR GO; GO:0045948; P:positive regulation of translational initiation; ISS:BHF-UCL.
DR GO; GO:0051726; P:regulation of cell cycle; TAS:ProtInc.
DR InterPro; IPR009772; CDC123.
DR PANTHER; PTHR15323; PTHR15323; 1.
DR Pfam; PF07065; D123; 1.
DR PIRSF; PIRSF007807; Cdc123; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Cytoplasm; Phosphoprotein; Reference proteome.
FT CHAIN 1..336
FT /note="Cell division cycle protein 123 homolog"
FT /id="PRO_0000228662"
FT MOD_RES 60
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT CONFLICT 93
FT /note="A -> P (in Ref. 1; BAA03593)"
FT /evidence="ECO:0000305"
FT CONFLICT 317
FT /note="E -> R (in Ref. 1; BAA03593)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 336 AA; 39135 MW; B13CF241D06C9D25 CRC64;
MKKEHVLHCQ FSAWYPFFRG VTIKSVILPL PQNVKDYLLD DGTLVVSGRD DPPTHSQPDS
DDEAEEIQWS DDENTATLTA PEFPEFATKV QEAINSLGGS VFPKLNWSAP RDAYWIAMNS
SLKCKTLSDI FLLFKSSDFI TRDFTQPFIH CTDDSPDPCI EYELVLRKWC ELIPGAEFRC
FVKENKLIGI SQRDYTQYYD HISKQKEEIR RCIQDFFKKH IQYKFLDEDF VFDIYRDSRG
KVWLIDFNPF GEVTDSLLFT WEELISENNL NGDFSEVDAQ EQDSPAFRCT NSEVTVQPSP
YLSYRLPKDF VDLSTGEDAH KLIDFLKLKR NQQEDD
