ID   CD123_KLULA             Reviewed;         366 AA.
AC   Q6CL84;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Cell division cycle protein 123;
GN   Name=CDC123; OrderedLocusNames=KLLA0F04972g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Regulates the cell cycle in a nutrient dependent manner.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CDC123 family. {ECO:0000305}.
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DR   EMBL; CR382126; CAG98013.1; -; Genomic_DNA.
DR   RefSeq; XP_455305.1; XM_455305.1.
DR   AlphaFoldDB; Q6CL84; -.
DR   SMR; Q6CL84; -.
DR   STRING; 28985.XP_455305.1; -.
DR   EnsemblFungi; CAG98013; CAG98013; KLLA0_F04972g.
DR   GeneID; 2895928; -.
DR   KEGG; kla:KLLA0_F04972g; -.
DR   eggNOG; KOG2983; Eukaryota.
DR   HOGENOM; CLU_034402_2_0_1; -.
DR   InParanoid; Q6CL84; -.
DR   OMA; RDLNHFD; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:EnsemblFungi.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:EnsemblFungi.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:1905143; P:eukaryotic translation initiation factor 2 complex assembly; IEA:EnsemblFungi.
DR   GO; GO:0045948; P:positive regulation of translational initiation; IEA:EnsemblFungi.
DR   InterPro; IPR009772; CDC123.
DR   PANTHER; PTHR15323; PTHR15323; 1.
DR   Pfam; PF07065; D123; 1.
DR   PIRSF; PIRSF007807; Cdc123; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cytoplasm; Reference proteome.
FT   CHAIN           1..366
FT                   /note="Cell division cycle protein 123"
FT                   /id="PRO_0000350944"
FT   REGION          79..108
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        81..100
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   366 AA;  42831 MW;  916AF3227BFAA776 CRC64;
     MAAESYTPLV DIKVRSDDIR ACSFSSWYDK FKKYTPKAKI IQPLPEEFLR YLAQDGIRLS
     LEENDSTYND HCLKRDDDNE YSDWEADDDG DNDSDSDDDK NGKEEEMVPM VNFPDLHREI
     AEVIGEYGAV TPKLNWSAPR DATWILPNNT SKCMNVNDIY LLLNASNYIA YDLDHAFDEC
     EDRDNSDNQS IQFELVLRKW FDINPALEFR VFVRDSEIWG ISQRDLNYYN YLEPLQDTFT
     NLIEEFVYDI VLPNFDLKSF VLDVYLPRPF ESCWLIDINP WSRTTDPLLF SWNELASKDL
     DSDASPEIRL ITEHNMGRFV TKEHSENQVP KDVVQASLDP ESMRELTYKW KEILKMQEAE
     SDSDSN