CD123_MOUSE
ID CD123_MOUSE Reviewed; 336 AA.
AC Q8CII2; Q3TTR0; Q8VE51;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Cell division cycle protein 123 homolog;
GN Name=Cdc123;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Spinal cord, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N, and FVB/N-3; TISSUE=Eye, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, Liver, Lung, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Required for S phase entry of the cell cycle. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8CII2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8CII2-2; Sequence=VSP_017691, VSP_017692;
CC -!- PTM: Phosphorylated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CDC123 family. {ECO:0000305}.
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DR EMBL; AK090122; BAC41103.1; -; mRNA.
DR EMBL; AK141463; BAE24692.1; -; mRNA.
DR EMBL; AK159208; BAE34899.1; -; mRNA.
DR EMBL; AK161246; BAE36265.1; -; mRNA.
DR EMBL; BC019753; AAH19753.1; -; mRNA.
DR EMBL; BC022972; AAH22972.1; -; mRNA.
DR EMBL; BC023821; AAH23821.1; -; mRNA.
DR EMBL; BC024787; AAH24787.1; -; mRNA.
DR CCDS; CCDS15666.1; -. [Q8CII2-1]
DR RefSeq; NP_598598.1; NM_133837.4. [Q8CII2-1]
DR RefSeq; XP_006497629.1; XM_006497566.2.
DR AlphaFoldDB; Q8CII2; -.
DR SMR; Q8CII2; -.
DR BioGRID; 221145; 1.
DR STRING; 10090.ENSMUSP00000043033; -.
DR iPTMnet; Q8CII2; -.
DR PhosphoSitePlus; Q8CII2; -.
DR EPD; Q8CII2; -.
DR MaxQB; Q8CII2; -.
DR PaxDb; Q8CII2; -.
DR PeptideAtlas; Q8CII2; -.
DR PRIDE; Q8CII2; -.
DR ProteomicsDB; 281131; -. [Q8CII2-1]
DR ProteomicsDB; 281132; -. [Q8CII2-2]
DR Antibodypedia; 24692; 425 antibodies from 31 providers.
DR Ensembl; ENSMUST00000043864; ENSMUSP00000043033; ENSMUSG00000039128. [Q8CII2-1]
DR GeneID; 98828; -.
DR KEGG; mmu:98828; -.
DR UCSC; uc008ift.1; mouse. [Q8CII2-1]
DR UCSC; uc008ifu.1; mouse. [Q8CII2-2]
DR CTD; 8872; -.
DR MGI; MGI:2138811; Cdc123.
DR VEuPathDB; HostDB:ENSMUSG00000039128; -.
DR eggNOG; KOG2983; Eukaryota.
DR GeneTree; ENSGT00390000003057; -.
DR HOGENOM; CLU_034402_0_0_1; -.
DR InParanoid; Q8CII2; -.
DR OMA; RDLNHFD; -.
DR OrthoDB; 1539674at2759; -.
DR PhylomeDB; Q8CII2; -.
DR TreeFam; TF323348; -.
DR BioGRID-ORCS; 98828; 23 hits in 73 CRISPR screens.
DR ChiTaRS; Cdc123; mouse.
DR PRO; PR:Q8CII2; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8CII2; protein.
DR Bgee; ENSMUSG00000039128; Expressed in ventricular zone and 269 other tissues.
DR ExpressionAtlas; Q8CII2; baseline and differential.
DR Genevisible; Q8CII2; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR InterPro; IPR009772; CDC123.
DR PANTHER; PTHR15323; PTHR15323; 1.
DR Pfam; PF07065; D123; 1.
DR PIRSF; PIRSF007807; Cdc123; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell cycle; Cell division; Cytoplasm; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..336
FT /note="Cell division cycle protein 123 homolog"
FT /id="PRO_0000228664"
FT REGION 48..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 60
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O75794"
FT VAR_SEQ 164..194
FT /note="LVLRKWCELIPGAEFRCFVKENKLIGISQRD -> PNLVQCLYLHDLCLPAR
FT ATTYLLSIAFKIAP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_017691"
FT VAR_SEQ 195..336
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_017692"
FT CONFLICT 213
FT /note="I -> T (in Ref. 2; AAH23821)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 336 AA; 38816 MW; 1E59461A424B7A76 CRC64;
MKKEHVSHCQ FSAWYPLFRS LTIKSVILPL PQNVKDYLLD DGTLVVSGRE DPPTCSQSDS
GNEAEETQWS DDESTATLTA PEFPEFNTQV QEAINSLGGS VFPKLNWSAP RDAYWIAMNS
SLKCKTLSDI FLLFKSSDFI THDFTQPFIH CTDDSPDPCI EYELVLRKWC ELIPGAEFRC
FVKENKLIGI SQRDYTQYYD HISKQKEEIC RCIQDFFKEH LQYKFLDEDF VFDIYRDSRG
KVWLIDFNPF GEVTDSLLFT WEELTSENNL RGEVTEGDAQ EQDSPAFRCT NSEVTVQPSP
YLSFGLPKDF VDLSTGEDAH KLIDFLKLKR NEQEDD
