CD123_SCHPO
ID CD123_SCHPO Reviewed; 319 AA.
AC Q9P7N5;
DT 23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 111.
DE RecName: Full=Cell division cycle protein 123;
GN Name=cdc123; ORFNames=SPAP27G11.03;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Regulates the cell cycle in a nutrient dependent manner.
CC {ECO:0000250}.
CC -!- INTERACTION:
CC Q9P7N5; P32481: GCD11; Xeno; NbExp=4; IntAct=EBI-16165908, EBI-8924;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the CDC123 family. {ECO:0000305}.
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DR EMBL; CU329670; CAB76024.1; -; Genomic_DNA.
DR RefSeq; NP_593407.1; NM_001018840.2.
DR PDB; 4ZGN; X-ray; 2.90 A; A=1-319.
DR PDB; 4ZGO; X-ray; 2.06 A; A/B=1-319.
DR PDB; 4ZGP; X-ray; 1.85 A; A/B=1-274.
DR PDB; 4ZGQ; X-ray; 3.00 A; A=1-319.
DR PDBsum; 4ZGN; -.
DR PDBsum; 4ZGO; -.
DR PDBsum; 4ZGP; -.
DR PDBsum; 4ZGQ; -.
DR AlphaFoldDB; Q9P7N5; -.
DR SMR; Q9P7N5; -.
DR BioGRID; 278360; 1.
DR DIP; DIP-61798N; -.
DR IntAct; Q9P7N5; 1.
DR STRING; 4896.SPAP27G11.03.1; -.
DR iPTMnet; Q9P7N5; -.
DR SwissPalm; Q9P7N5; -.
DR MaxQB; Q9P7N5; -.
DR PaxDb; Q9P7N5; -.
DR PRIDE; Q9P7N5; -.
DR EnsemblFungi; SPAP27G11.03.1; SPAP27G11.03.1:pep; SPAP27G11.03.
DR GeneID; 2541870; -.
DR KEGG; spo:SPAP27G11.03; -.
DR PomBase; SPAP27G11.03; cdc123.
DR VEuPathDB; FungiDB:SPAP27G11.03; -.
DR eggNOG; KOG2983; Eukaryota.
DR HOGENOM; CLU_034402_2_0_1; -.
DR InParanoid; Q9P7N5; -.
DR OMA; RDLNHFD; -.
DR PhylomeDB; Q9P7N5; -.
DR PRO; PR:Q9P7N5; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IDA:PomBase.
DR GO; GO:0000287; F:magnesium ion binding; IDA:PomBase.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; ISO:PomBase.
DR InterPro; IPR009772; CDC123.
DR PANTHER; PTHR15323; PTHR15323; 1.
DR Pfam; PF07065; D123; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell cycle; Cell division; Cytoplasm; Nucleus;
KW Reference proteome.
FT CHAIN 1..319
FT /note="Cell division cycle protein 123"
FT /id="PRO_0000350948"
FT HELIX 7..12
FT /evidence="ECO:0007829|PDB:4ZGP"
FT HELIX 15..21
FT /evidence="ECO:0007829|PDB:4ZGP"
FT HELIX 23..25
FT /evidence="ECO:0007829|PDB:4ZGP"
FT STRAND 29..34
FT /evidence="ECO:0007829|PDB:4ZGP"
FT HELIX 37..43
FT /evidence="ECO:0007829|PDB:4ZGP"
FT STRAND 45..47
FT /evidence="ECO:0007829|PDB:4ZGN"
FT HELIX 76..88
FT /evidence="ECO:0007829|PDB:4ZGP"
FT STRAND 93..96
FT /evidence="ECO:0007829|PDB:4ZGP"
FT HELIX 103..108
FT /evidence="ECO:0007829|PDB:4ZGP"
FT STRAND 109..114
FT /evidence="ECO:0007829|PDB:4ZGP"
FT STRAND 116..118
FT /evidence="ECO:0007829|PDB:4ZGN"
FT HELIX 119..127
FT /evidence="ECO:0007829|PDB:4ZGP"
FT HELIX 130..138
FT /evidence="ECO:0007829|PDB:4ZGP"
FT TURN 139..142
FT /evidence="ECO:0007829|PDB:4ZGP"
FT STRAND 161..165
FT /evidence="ECO:0007829|PDB:4ZGP"
FT HELIX 171..173
FT /evidence="ECO:0007829|PDB:4ZGP"
FT STRAND 174..180
FT /evidence="ECO:0007829|PDB:4ZGP"
FT STRAND 183..193
FT /evidence="ECO:0007829|PDB:4ZGP"
FT HELIX 197..200
FT /evidence="ECO:0007829|PDB:4ZGP"
FT HELIX 202..214
FT /evidence="ECO:0007829|PDB:4ZGP"
FT TURN 215..218
FT /evidence="ECO:0007829|PDB:4ZGP"
FT STRAND 222..231
FT /evidence="ECO:0007829|PDB:4ZGP"
FT STRAND 234..244
FT /evidence="ECO:0007829|PDB:4ZGP"
FT HELIX 254..259
FT /evidence="ECO:0007829|PDB:4ZGP"
FT STRAND 268..270
FT /evidence="ECO:0007829|PDB:4ZGP"
FT HELIX 299..308
FT /evidence="ECO:0007829|PDB:4ZGN"
FT TURN 309..314
FT /evidence="ECO:0007829|PDB:4ZGN"
SQ SEQUENCE 319 AA; 36897 MW; 352B195577263030 CRC64;
MTLILTKNQV LHCQFSSWYS LFRKLTPKAK VIKPIPATVL KYLHEDSIYV EQPMNTVEEV
DSEEDEESAP AYYPEREAIQ LIEKAIKELG GAVVPKLNWS TPKDALWITT TGSLKCTTAE
EVLLLLKSSD FVAHDLNHAF DDCKDFDNAD GSVPKDFSFE LVLKEWFPMH ASTEFRCFVK
SKRLIAFCQR DDNYYEFLKE NIDCYEKLIS DLLKKLDTFP DPDFVFDVYI HKDRAWLIDI
NPFYPRTDGL LFSWSELESM NSENMKPEIR LIPKGSMPST GSAKYYTNRV PFDMIAASEG
ENLLEFAQKW QDLTNKSNE
