ID   CD123_YARLI             Reviewed;         371 AA.
AC   Q6C101;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Cell division cycle protein 123;
GN   Name=CDC123; OrderedLocusNames=YALI0F20394g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Regulates the cell cycle in a nutrient dependent manner.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CDC123 family. {ECO:0000305}.
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DR   EMBL; CR382132; CAG78470.1; -; Genomic_DNA.
DR   RefSeq; XP_505661.1; XM_505661.1.
DR   AlphaFoldDB; Q6C101; -.
DR   SMR; Q6C101; -.
DR   STRING; 4952.CAG78470; -.
DR   EnsemblFungi; CAG78470; CAG78470; YALI0_F20394g.
DR   GeneID; 2907865; -.
DR   KEGG; yli:YALI0F20394g; -.
DR   VEuPathDB; FungiDB:YALI0_F20394g; -.
DR   HOGENOM; CLU_034402_2_0_1; -.
DR   InParanoid; Q6C101; -.
DR   OMA; FTWHELL; -.
DR   Proteomes; UP000001300; Chromosome F.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:EnsemblFungi.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:EnsemblFungi.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:1905143; P:eukaryotic translation initiation factor 2 complex assembly; IEA:EnsemblFungi.
DR   GO; GO:0045948; P:positive regulation of translational initiation; IEA:EnsemblFungi.
DR   InterPro; IPR009772; CDC123.
DR   PANTHER; PTHR15323; PTHR15323; 1.
DR   Pfam; PF07065; D123; 1.
DR   PIRSF; PIRSF007807; Cdc123; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cytoplasm; Reference proteome.
FT   CHAIN           1..371
FT                   /note="Cell division cycle protein 123"
FT                   /id="PRO_0000350951"
FT   REGION          334..371
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        346..371
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   371 AA;  42506 MW;  02E4A29754D4C694 CRC64;
     MIINDKKDQE TKVDDTTTLT LTREHLLNCQ FSAWYKLYKS ITPKTRIIKP LPEDFVNYLS
     EDGVILPDEE KTSYGSDSGV FEEYSDDEDE LDSYVSKLDD FHPKVQAVID EFGAVAPKLN
     WSSPQDAIWI SPSNSTRCVT VNDVYLLLKS SDYIAHDLTM LDKLGGIPKD FSFELVLRKW
     ININPALEFR CFVKDRELIA VTQRDQNYYE FLIKLKERFL GEIELFFYEH IKDTFPDSSF
     VFDVYIPEPY DKVWLMDFNV FYPTTDSLIE WSTLVNLDAT SPSFDLDLLL IDKELRNASF
     ACQRHSQNKV PMDIVNASMD TEAMVEMLRS QQREMDRLDG DQGGEASATG DTTGDSVANE
     TTAANTTSQD S