ID   CD123_YEAS7             Reviewed;         360 AA.
AC   A7A1A3;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Cell division cycle protein 123;
GN   Name=CDC123; ORFNames=SCY_3781;
OS   Saccharomyces cerevisiae (strain YJM789) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=307796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJM789;
RX   PubMed=17652520; DOI=10.1073/pnas.0701291104;
RA   Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z.,
RA   Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X.,
RA   Jia P., Luedi P., Oefner P.J., David L., Dietrich F.S., Li Y., Davis R.W.,
RA   Steinmetz L.M.;
RT   "Genome sequencing and comparative analysis of Saccharomyces cerevisiae
RT   strain YJM789.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007).
CC   -!- FUNCTION: Regulates the cell cycle in a nutrient dependent manner.
CC       Accumulates in presence of nutrients and directs the destabilization of
CC       DMA1 and DMA2, whose accumulation results in a G1 block. Regulates also
CC       the abundance of GCD11 an essential component of the translational
CC       initiation factor 2 (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with DMA1, DMA2 and GCD11. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CDC123 family. {ECO:0000305}.
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DR   EMBL; AAFW02000169; EDN59436.1; -; Genomic_DNA.
DR   AlphaFoldDB; A7A1A3; -.
DR   SMR; A7A1A3; -.
DR   PRIDE; A7A1A3; -.
DR   EnsemblFungi; EDN59436; EDN59436; SCY_3781.
DR   HOGENOM; CLU_034402_2_0_1; -.
DR   Proteomes; UP000007060; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   InterPro; IPR009772; CDC123.
DR   PANTHER; PTHR15323; PTHR15323; 1.
DR   Pfam; PF07065; D123; 1.
DR   PIRSF; PIRSF007807; Cdc123; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cytoplasm.
FT   CHAIN           1..360
FT                   /note="Cell division cycle protein 123"
FT                   /id="PRO_0000350952"
SQ   SEQUENCE   360 AA;  41825 MW;  61CCD82CEAFA1197 CRC64;
     MSSQEYTTFI DIPVTRAQVE HCSYSFWSSL YPKYVPKSIV LKSLPKKFIQ YLEQDGIKLP
     QEENSRSVYT EEIIRNEDND YSDWEDDEDT ATEFVQEVEP LIDFPELHQK LKDALNELGA
     VAPKLNWSAP RDATWILPNN TMKCNEVNEL YLLLNASNYI MHDLQRAFKG CVDGDDIKGL
     KFDLVLRQWC DMNPALEFRV FVKNAHIVGA TQRDLNYYDY LDELSDTFKD LIDEIVHDVV
     LPKFPDKSFV LDVYIPRPFN KIFIVDINPF ARKTDSLLFS WNEIAAIAPP KNDVEDYELR
     LVTRHNTGRF ASKEHSENHV PQDLVEASLN PEAIRELTQK WKELLSQQAK EESSDSESET