CD151_RAT
ID CD151_RAT Reviewed; 253 AA.
AC Q9QZA6;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 2.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=CD151 antigen;
DE AltName: Full=Platelet-endothelial tetraspan antigen 3;
DE Short=PETA-3;
DE AltName: CD_antigen=CD151;
GN Name=Cd151; Synonyms=Peta3;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Wistar;
RX PubMed=11682256; DOI=10.1016/s0893-133x(01)00269-x;
RA Hua L.V., Green M., Wong A., Warsh J.J., Li P.P.;
RT "Tetraspan protein CD151: a common target of mood stabilizing drugs?";
RL Neuropsychopharmacology 25:729-736(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PROTEIN SEQUENCE OF 9-17 AND 134-148, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RA Lubec G., Kang S.U., Lubec S.;
RL Submitted (SEP-2007) to UniProtKB.
CC -!- FUNCTION: Essential for the proper assembly of the glomerular and
CC tubular basement membranes in kidney. {ECO:0000250|UniProtKB:P48509}.
CC -!- SUBUNIT: Interacts with integrins ITGA3:ITGB1, ITGA5:ITGB1, ITGA3:ITGB1
CC and ITGA6:ITGB4 and with CD9 and CD181. Interacts (via the second
CC extracellular domain) with integrin ITGAV:ITGB3.
CC {ECO:0000250|UniProtKB:P48509}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- PTM: Palmitoylated. Palmitoylation by ZDHHC2 regulates CD151
CC expression, association with other tetraspanin family proteins and
CC function in cell adhesion. {ECO:0000250|UniProtKB:P48509}.
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
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DR EMBL; AF192547; AAF05763.2; -; mRNA.
DR EMBL; BC072515; AAH72515.1; -; mRNA.
DR RefSeq; NP_071968.1; NM_022523.1.
DR RefSeq; XP_003749065.1; XM_003749017.4.
DR RefSeq; XP_006230638.1; XM_006230576.3.
DR RefSeq; XP_006230660.1; XM_006230598.3.
DR RefSeq; XP_017445147.1; XM_017589658.1.
DR RefSeq; XP_017445148.1; XM_017589659.1.
DR RefSeq; XP_017445742.1; XM_017590253.1.
DR RefSeq; XP_017445743.1; XM_017590254.1.
DR RefSeq; XP_017459719.1; XM_017604230.1.
DR RefSeq; XP_017459724.1; XM_017604235.1.
DR RefSeq; XP_017459725.1; XM_017604236.1.
DR RefSeq; XP_017459726.1; XM_017604237.1.
DR AlphaFoldDB; Q9QZA6; -.
DR SMR; Q9QZA6; -.
DR STRING; 10116.ENSRNOP00000066223; -.
DR GlyGen; Q9QZA6; 1 site, 3 N-linked glycans (1 site).
DR iPTMnet; Q9QZA6; -.
DR PhosphoSitePlus; Q9QZA6; -.
DR jPOST; Q9QZA6; -.
DR PaxDb; Q9QZA6; -.
DR PRIDE; Q9QZA6; -.
DR Ensembl; ENSRNOT00000089241; ENSRNOP00000073673; ENSRNOG00000062573.
DR GeneID; 64315; -.
DR KEGG; rno:64315; -.
DR UCSC; RGD:621290; rat.
DR CTD; 977; -.
DR RGD; 621290; Cd151.
DR eggNOG; KOG3882; Eukaryota.
DR GeneTree; ENSGT00940000157760; -.
DR HOGENOM; CLU_055524_5_0_1; -.
DR InParanoid; Q9QZA6; -.
DR OMA; WADSLWI; -.
DR OrthoDB; 1051357at2759; -.
DR PhylomeDB; Q9QZA6; -.
DR TreeFam; TF352892; -.
DR Reactome; R-RNO-2022090; Assembly of collagen fibrils and other multimeric structures.
DR Reactome; R-RNO-446107; Type I hemidesmosome assembly.
DR PRO; PR:Q9QZA6; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000019215; Expressed in ovary and 19 other tissues.
DR Genevisible; Q9QZA6; RN.
DR GO; GO:0005604; C:basement membrane; ISO:RGD.
DR GO; GO:0009986; C:cell surface; ISO:RGD.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005178; F:integrin binding; IPI:RGD.
DR GO; GO:0016477; P:cell migration; ISO:RGD.
DR GO; GO:0030335; P:positive regulation of cell migration; ISO:RGD.
DR GO; GO:0045807; P:positive regulation of endocytosis; ISO:RGD.
DR GO; GO:0042098; P:T cell proliferation; ISO:RGD.
DR GO; GO:0044319; P:wound healing, spreading of cells; ISO:RGD.
DR Gene3D; 1.10.1450.10; -; 1.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR000301; Tetraspanin_animals.
DR InterPro; IPR018503; Tetraspanin_CS.
DR InterPro; IPR008952; Tetraspanin_EC2_sf.
DR PANTHER; PTHR19282; PTHR19282; 1.
DR Pfam; PF00335; Tetraspanin; 1.
DR PIRSF; PIRSF002419; Tetraspanin; 1.
DR SUPFAM; SSF48652; SSF48652; 1.
DR PROSITE; PS00421; TM4_1; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Glycoprotein; Lipoprotein; Membrane; Palmitate;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..253
FT /note="CD151 antigen"
FT /id="PRO_0000219233"
FT TOPO_DOM 1..18
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 19..39
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 40..57
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..91
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 113..221
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 222..242
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 243..253
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT LIPID 11
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250|UniProtKB:P48509"
FT LIPID 15
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250|UniProtKB:P48509"
FT LIPID 242
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250|UniProtKB:P48509"
FT LIPID 243
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250|UniProtKB:P48509"
FT CARBOHYD 159
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 253 AA; 28355 MW; 51876AF31B4DCB2B CRC64;
MGEFNEKKAT CGTVCLKYLL FTYNCCFWLA GLAVMAVGIW TLALKSDYIS LLASSTYLAT
AYILVVAGVV VMVTGVLGCC ATFKERRNLL RLYFILLLII FLLEIIAGIL AYVYYQQLNT
ELKENLKDTM IKRYHQSGHE GVTNAVDKLQ QEFHCCGSNN SRDWRDSEWI RSGEADSRVV
PDSCCKTVVT GCGKREHASN IYKVEGGCIT KLESFIQEHL RVIGAVGIGI ACVQVFGMIF
TCCLYRSLKL EHY