CD158_HUMAN
ID CD158_HUMAN Reviewed; 1113 AA.
AC Q5M9N0; Q8IYQ1; Q8N7D4; Q8N7E3;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 2.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Coiled-coil domain-containing protein 158;
GN Name=CCDC158;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 160-1113 (ISOFORM 1).
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 15-1113 (ISOFORM 2), AND
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 611-1113 (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- INTERACTION:
CC Q5M9N0-2; P07550: ADRB2; NbExp=3; IntAct=EBI-21796846, EBI-491169;
CC Q5M9N0-2; P22607: FGFR3; NbExp=3; IntAct=EBI-21796846, EBI-348399;
CC Q5M9N0-2; Q14957: GRIN2C; NbExp=3; IntAct=EBI-21796846, EBI-8285963;
CC Q5M9N0-2; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-21796846, EBI-5235340;
CC Q5M9N0-2; Q86WV8: TSC1; NbExp=3; IntAct=EBI-21796846, EBI-12806590;
CC Q5M9N0-2; P54577: YARS1; NbExp=3; IntAct=EBI-21796846, EBI-1048893;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q5M9N0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5M9N0-2; Sequence=VSP_032391;
CC Name=3;
CC IsoId=Q5M9N0-3; Sequence=VSP_032390, VSP_032392;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC05347.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC05359.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BC035224; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AC034139; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC096743; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC035224; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC086869; AAH86869.1; -; mRNA.
DR EMBL; AK098600; BAC05347.1; ALT_INIT; mRNA.
DR EMBL; AK098636; BAC05359.1; ALT_INIT; mRNA.
DR CCDS; CCDS43242.1; -. [Q5M9N0-1]
DR RefSeq; NP_001036249.1; NM_001042784.1. [Q5M9N0-1]
DR RefSeq; XP_005263031.1; XM_005262974.4. [Q5M9N0-1]
DR AlphaFoldDB; Q5M9N0; -.
DR SMR; Q5M9N0; -.
DR BioGRID; 130969; 19.
DR DIP; DIP-47314N; -.
DR IntAct; Q5M9N0; 20.
DR MINT; Q5M9N0; -.
DR STRING; 9606.ENSP00000373566; -.
DR GlyGen; Q5M9N0; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q5M9N0; -.
DR PhosphoSitePlus; Q5M9N0; -.
DR BioMuta; CCDC158; -.
DR DMDM; 172045891; -.
DR EPD; Q5M9N0; -.
DR MassIVE; Q5M9N0; -.
DR MaxQB; Q5M9N0; -.
DR PaxDb; Q5M9N0; -.
DR PeptideAtlas; Q5M9N0; -.
DR PRIDE; Q5M9N0; -.
DR ProteomicsDB; 63568; -. [Q5M9N0-1]
DR ProteomicsDB; 63569; -. [Q5M9N0-2]
DR ProteomicsDB; 63570; -. [Q5M9N0-3]
DR Antibodypedia; 6349; 78 antibodies from 19 providers.
DR DNASU; 339965; -.
DR Ensembl; ENST00000388914.7; ENSP00000373566.2; ENSG00000163749.18. [Q5M9N0-1]
DR Ensembl; ENST00000434846.2; ENSP00000401742.2; ENSG00000163749.18. [Q5M9N0-3]
DR GeneID; 339965; -.
DR KEGG; hsa:339965; -.
DR UCSC; uc003hkb.5; human. [Q5M9N0-1]
DR CTD; 339965; -.
DR DisGeNET; 339965; -.
DR GeneCards; CCDC158; -.
DR HGNC; HGNC:26374; CCDC158.
DR HPA; ENSG00000163749; Tissue enriched (testis).
DR neXtProt; NX_Q5M9N0; -.
DR OpenTargets; ENSG00000163749; -.
DR PharmGKB; PA164717707; -.
DR VEuPathDB; HostDB:ENSG00000163749; -.
DR eggNOG; KOG1836; Eukaryota.
DR GeneTree; ENSGT00390000013339; -.
DR HOGENOM; CLU_009414_0_0_1; -.
DR InParanoid; Q5M9N0; -.
DR OMA; SYPGKEH; -.
DR OrthoDB; 197998at2759; -.
DR PhylomeDB; Q5M9N0; -.
DR TreeFam; TF337019; -.
DR PathwayCommons; Q5M9N0; -.
DR SignaLink; Q5M9N0; -.
DR BioGRID-ORCS; 339965; 14 hits in 1060 CRISPR screens.
DR GenomeRNAi; 339965; -.
DR Pharos; Q5M9N0; Tdark.
DR PRO; PR:Q5M9N0; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q5M9N0; protein.
DR Bgee; ENSG00000163749; Expressed in sperm and 92 other tissues.
DR Genevisible; Q5M9N0; HS.
DR InterPro; IPR031809; CCDC158.
DR PANTHER; PTHR47615; PTHR47615; 1.
DR Pfam; PF15921; CCDC158; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..1113
FT /note="Coiled-coil domain-containing protein 158"
FT /id="PRO_0000325760"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 848..902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 955..1062
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 72..183
FT /evidence="ECO:0000255"
FT COILED 243..833
FT /evidence="ECO:0000255"
FT COILED 1061..1113
FT /evidence="ECO:0000255"
FT COMPBIAS 8..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 849..891
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 955..978
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 994..1062
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 344..406
FT /note="TEELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLLADLHKREKELSL
FT EKEQNKRLWDR -> ENLQNSPLRIWTSRSCHYWLCRFGFTLNFRFLTTKISPDVDSAF
FT IFTTLKAVGAEFCIKKVMI (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032390"
FT VAR_SEQ 368..947
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_032391"
FT VAR_SEQ 407..1113
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032392"
FT VARIANT 232
FT /note="E -> D (in dbSNP:rs17001889)"
FT /id="VAR_039909"
FT VARIANT 297
FT /note="I -> V (in dbSNP:rs17001885)"
FT /id="VAR_039910"
SQ SEQUENCE 1113 AA; 127140 MW; D56CE9B93AFAF24D CRC64;
MESKAWESNN EDLLSSSGVT SNGGSSSSFF VSSIRGTIIE NTSSAGTLTQ VPFFPKYEVE
LDSPRKIIPS PGKEHFERVL EEYSHQVKDL QRRLNESNEL HEKQKFYLRQ SVIDLQTKLQ
EMQMERDAMA DIRRRESQSQ EDLRNQLQNT VHELEAAKCL KEDMLKDSNT QIEQLRKMML
SHEGVLQEIR SILVDFEEAS GKKICEHDSM STLHFRSLGS AISKILRELD TEISYLKGRI
FPVEDQLEAL KSESQNKIEL LLQQHQDRIE QLISEHEVEI TGLTEKASSA RSQANSIQSQ
MEIIQEQARN QNSMYMRQLS DLESTVSQLR SELREAKRMY EDKTEELEKQ LVLANSELTE
ARTERDQFSQ ESGNLDDQLQ KLLADLHKRE KELSLEKEQN KRLWDRDTGN SITIDHLRRE
LDNRNMEVQR LEALLKALKS ECQGQMERQM AAIQGKNESL EKVSSLTAQL ESTKEMLRKV
VEELTAKKMT LESSERTISD LTTSLQEKER AIEATNAEIT KLRSRVDLKL QELQHLKNEG
DHLRNVQTEC EALKLQMTEK DKVIEILRQQ IENMTQLVGQ HGRTAGAMQV EKAQLEKEIN
DRRMELKELK ILKDKKDAKI RELEARVSDL ELEKVKLVNA GSERLRAVKD IKQERDQLLN
EVKTSRSELN NLSEEYEVLK RNFRNKSEEM EMTTNKLKMQ LKSAQSELEQ TRNTLKSMEG
SDGHAMKVAM GMQKQITAKR GQIDALQSKI QFLEEAMTNA NKEKHFLKEE KSKLSQELST
VATEKNKMAG ELEVLRSQER RLKEKVTNME VALDKASLQF AECQDIIQRQ EQESVRLKLQ
HTLDIKELQG PGYTSNSSLK PRLLQPASVT RSHSNVPSSQ STASFLSHHS TKANTLKEDP
TRDLKQLLQE LRSVINEEPA VSLSKTEEDG RTSLGALEDR VRDCITESSL RSDMCHRSNN
SLRDSTEGSK SSETLSREPV TLHAGDREDP SGCFTFTSAA SPSVKNSASR SFNSSPKKSP
VHSLLTSSVE GSIGSTSQYR SAKPIHSSDS VKDSQSPPIE TTGKTCRKLQ NRLESLQTLV
EDLQLKNQAM SSMIRNQEKR IQKVKDQEKM LLK
