CD158_MOUSE
ID CD158_MOUSE Reviewed; 1109 AA.
AC Q8CDI6; Q3TU97;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Coiled-coil domain-containing protein 158;
GN Name=Ccdc158;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8CDI6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8CDI6-2; Sequence=VSP_032393, VSP_032394;
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DR EMBL; AK029997; BAC26724.1; -; mRNA.
DR EMBL; AK160895; BAE36074.1; -; mRNA.
DR CCDS; CCDS19434.1; -. [Q8CDI6-1]
DR CCDS; CCDS89939.1; -. [Q8CDI6-2]
DR RefSeq; NP_796204.1; NM_177230.3. [Q8CDI6-1]
DR AlphaFoldDB; Q8CDI6; -.
DR SMR; Q8CDI6; -.
DR BioGRID; 236222; 7.
DR STRING; 10090.ENSMUSP00000063050; -.
DR iPTMnet; Q8CDI6; -.
DR PhosphoSitePlus; Q8CDI6; -.
DR PaxDb; Q8CDI6; -.
DR PRIDE; Q8CDI6; -.
DR ProteomicsDB; 281260; -. [Q8CDI6-1]
DR ProteomicsDB; 281261; -. [Q8CDI6-2]
DR Antibodypedia; 6349; 78 antibodies from 19 providers.
DR DNASU; 320696; -.
DR Ensembl; ENSMUST00000060930; ENSMUSP00000063050; ENSMUSG00000050050. [Q8CDI6-1]
DR Ensembl; ENSMUST00000150359; ENSMUSP00000123259; ENSMUSG00000050050. [Q8CDI6-2]
DR Ensembl; ENSMUST00000151180; ENSMUSP00000117894; ENSMUSG00000050050. [Q8CDI6-2]
DR GeneID; 320696; -.
DR KEGG; mmu:320696; -.
DR UCSC; uc008ydr.1; mouse. [Q8CDI6-1]
DR UCSC; uc008yds.1; mouse. [Q8CDI6-2]
DR CTD; 339965; -.
DR MGI; MGI:2444555; Ccdc158.
DR VEuPathDB; HostDB:ENSMUSG00000050050; -.
DR eggNOG; ENOG502QX0B; Eukaryota.
DR GeneTree; ENSGT00390000013339; -.
DR HOGENOM; CLU_009414_0_0_1; -.
DR InParanoid; Q8CDI6; -.
DR OMA; SYPGKEH; -.
DR OrthoDB; 197998at2759; -.
DR PhylomeDB; Q8CDI6; -.
DR TreeFam; TF337019; -.
DR BioGRID-ORCS; 320696; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Ccdc158; mouse.
DR PRO; PR:Q8CDI6; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q8CDI6; protein.
DR Bgee; ENSMUSG00000050050; Expressed in spermatocyte and 66 other tissues.
DR ExpressionAtlas; Q8CDI6; baseline and differential.
DR Genevisible; Q8CDI6; MM.
DR InterPro; IPR031809; CCDC158.
DR PANTHER; PTHR47615; PTHR47615; 1.
DR Pfam; PF15921; CCDC158; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..1109
FT /note="Coiled-coil domain-containing protein 158"
FT /id="PRO_0000325761"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 843..897
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 952..1061
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 71..166
FT /evidence="ECO:0000255"
FT COILED 242..828
FT /evidence="ECO:0000255"
FT COILED 1053..1109
FT /evidence="ECO:0000255"
FT COMPBIAS 13..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 844..886
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 952..972
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 987..1061
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 343..354
FT /note="IEELEKQLVLAN -> EPPEFPFTNLDQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_032393"
FT VAR_SEQ 355..1109
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_032394"
SQ SEQUENCE 1109 AA; 126826 MW; 0EC006908D66C9B0 CRC64;
MESKACESKN EDLLPSGITS KGGSSSPFFV TSTHGTIIEN TSSTGTLTQM PFFPKYEVEL
DSPRKSTPYP GKEHIERVLE EYSHQVKDLQ RRLNESNELH EKQKFYLRQS VIDLQTKLQE
MQMERDAMAD IRRRESQSQE ESRNQLQNTV RELEAAKCLK EDMLKDSSTQ IEQLRKMMLS
HEGVLQEIRS ILVDFEEASG KKICEHDSMS TMHFRSLGSA ISKILRELDT EISFLKGRIF
PVEDQLETLK SESQNKIELL LQQHQDRIEQ LISEHEVEIT GLTEKASSAR SQANSVQSQL
EIIQEQARNQ NSMYMRQLSD LESTVSQLRS ELRESKRMYE DKIEELEKQL VLANSELTEA
RTERDQFSQE SGNLDDQLQK LLADLHKREK ELSLEKEQNK RLWDRDTGNS ITIDHLRREL
DDRNMEVQRL EALLKAMKSE CQGQMERQMA AIQGKNESLE KVSSLTAQLE STKEMLRKVV
EELTAKKMNL ESSERTVSDL TASLQEKERA IEATNAEITK LRSRVDLKLQ ELQHLKNEGD
HLRNVQTECE ALKLQMAEKD KVIEILRQQI ENMTQLVGQH GRTAGAMQVE KAQLEKEIND
RKLELQEFKI LKDKKDAKIR ELEARVSDLE LEKVKLVNAG SERLRAVKDI RHERDQLLNE
VKTSRTELNH LSEDYEVLKR NFRNKSEEME STTNRLKMQL KSAQSELEQT RNTLKTMEGS
DGHAMKVAMG MQKQITAKRG QIDALQSKVQ FLEEAVTSAN KERHFLKEEK SKLSQELSTV
ATEKNKMAGE LEVLRSQERR LKEKVANMEV ALDKFAECQD IIQRQEQESV RLKLQHTLDV
KELQGPGYTS NSSVKPRLLQ PASVTRSHSN IPSSQSTTSF LSHHSIKTNT PKEDPTRDLK
QLLQELRTVI NEEPAMALSK TEEDGRTPSL GALEDRVRDC ITESSLRAEL CHRSNNSLRE
STEGSKSSET LSREPVPLHP GDLEDPSSCF TFTSTASPSG KMSASRSFSS SPKKSPVHSL
LTSSAEESVN STPQYRSTKP IHSPTSAKDS QSPSLETTGK TCQKLQNRLE SLQTLVEDLQ
LKNQAMSSMI RNQEKRIQKV KDQEKMLLK
