CD1B_RABIT
ID CD1B_RABIT Reviewed; 109 AA.
AC P23042;
DT 01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1991, sequence version 1.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=T-cell surface glycoprotein CD1b;
DE AltName: Full=Leukocyte differentiation-like antigen Ta;
DE AltName: CD_antigen=CD1b;
DE Flags: Precursor; Fragment;
GN Name=CD1B;
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2478462; DOI=10.1007/bf02425277;
RA Calabi F., Belt K.T., Yu C.Y., Bradbury A., Mandy W.J., Milstein C.;
RT "The rabbit CD1 and the evolutionary conservation of the CD1 gene family.";
RL Immunogenetics 30:370-377(1989).
CC -!- FUNCTION: Antigen-presenting protein that binds self and non-self lipid
CC and glycolipid antigens and presents them to T-cell receptors on
CC natural killer T-cells. {ECO:0000250}.
CC -!- SUBUNIT: Heterodimer with B2M (beta-2-microglobulin). Interacts with
CC saposin C (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P29016};
CC Single-pass type I membrane protein {ECO:0000255}. Endosome membrane
CC {ECO:0000250|UniProtKB:P29016}; Single-pass type I membrane protein
CC {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:P29016};
CC Single-pass type I membrane protein {ECO:0000255}. Note=Subject to
CC intracellular trafficking between the cell membrane, endosomes and
CC lysosomes. {ECO:0000250|UniProtKB:P29016}.
CC -!- TISSUE SPECIFICITY: Expressed on cortical thymocytes, on certain T-cell
CC leukemias, and in various other tissues.
CC -!- MISCELLANEOUS: During protein synthesis and maturation, CD1 family
CC members bind endogenous lipids that are replaced by lipid or glycolipid
CC antigens when the proteins are internalized and pass through endosomes
CC or lysosomes, before trafficking back to the cell surface. Interaction
CC with saposin C is required for the loading of bacterial lipid antigens
CC onto CD1B in the lysosome (By similarity). {ECO:0000250}.
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DR EMBL; M26248; AAA31196.1; -; Genomic_DNA.
DR PIR; A45887; A45887.
DR AlphaFoldDB; P23042; -.
DR SMR; P23042; -.
DR STRING; 9986.ENSOCUP00000009701; -.
DR eggNOG; ENOG502SJH6; Eukaryota.
DR InParanoid; P23042; -.
DR Proteomes; UP000001811; Unplaced.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR Gene3D; 3.30.500.10; -; 1.
DR InterPro; IPR011161; MHC_I-like_Ag-recog.
DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR Pfam; PF16497; MHC_I_3; 1.
DR SUPFAM; SSF54452; SSF54452; 1.
PE 2: Evidence at transcript level;
KW Adaptive immunity; Cell membrane; Endosome; Glycoprotein; Immunity;
KW Immunoglobulin domain; Lysosome; Membrane; Reference proteome; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..>109
FT /note="T-cell surface glycoprotein CD1b"
FT /id="PRO_0000014594"
FT CARBOHYD 38
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 75
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT NON_TER 109
SQ SEQUENCE 109 AA; 12576 MW; 12E033FF5097C5FE CRC64;
MLLLPLLLLA GRFPGGDNED ALQGPTSYHV MQISSFTNST WTENRGSGWL EDLQIHRWDS
ETGTAIFLKP WSKGNLSDEE ITELVELFRV YFFGLVRELR DHVTEFQMK
