CD1D_PANTR
ID CD1D_PANTR Reviewed; 335 AA.
AC Q4ACW4; Q4ACU8;
DT 11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Antigen-presenting glycoprotein CD1d;
DE AltName: CD_antigen=CD1d;
DE Flags: Precursor;
GN Name=CD1D;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=16305684; DOI=10.1111/j.1399-0039.2005.00504.x;
RA Saito N., Takahashi M., Akahata W., Ido E., Hidaka C., Ibuki K., Miura T.,
RA Hayami M., Takahashi H.;
RT "Analysis of evolutionary conservation in CD1d molecules among primates.";
RL Tissue Antigens 66:674-682(2005).
CC -!- FUNCTION: Antigen-presenting protein that binds self and non-self
CC glycolipids and presents them to T-cell receptors on natural killer T-
CC cells. {ECO:0000250}.
CC -!- SUBUNIT: Heterodimer with B2M (beta-2-microglobulin). Interacts with
CC MHC II (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P15813};
CC Single-pass type I membrane protein {ECO:0000250|UniProtKB:P15813}.
CC Basolateral cell membrane {ECO:0000250|UniProtKB:P15813}; Single-pass
CC type I membrane protein {ECO:0000250|UniProtKB:P15813}. Endosome
CC membrane {ECO:0000250|UniProtKB:P15813}; Single-pass type I membrane
CC protein {ECO:0000250|UniProtKB:P15813}. Lysosome membrane
CC {ECO:0000250|UniProtKB:P15813}; Single-pass type I membrane protein
CC {ECO:0000250|UniProtKB:P15813}. Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:P15813}; Single-pass type I membrane protein
CC {ECO:0000250|UniProtKB:P15813}. Note=Subject to intracellular
CC trafficking between the cell membrane, endosomes and lysosomes.
CC {ECO:0000250|UniProtKB:P15813}.
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DR EMBL; AB222997; BAE16552.2; -; Genomic_DNA.
DR EMBL; AB222998; BAE16553.1; -; Genomic_DNA.
DR EMBL; AB223044; BAE16753.2; -; Genomic_DNA.
DR RefSeq; NP_001065272.1; NM_001071804.1.
DR RefSeq; XP_009432153.2; XM_009433878.2.
DR AlphaFoldDB; Q4ACW4; -.
DR SMR; Q4ACW4; -.
DR STRING; 9598.ENSPTRP00000002527; -.
DR PaxDb; Q4ACW4; -.
DR GeneID; 469524; -.
DR KEGG; ptr:469524; -.
DR CTD; 912; -.
DR eggNOG; ENOG502SJH6; Eukaryota.
DR HOGENOM; CLU_047501_9_2_1; -.
DR InParanoid; Q4ACW4; -.
DR OrthoDB; 827472at2759; -.
DR TreeFam; TF336723; -.
DR Proteomes; UP000002277; Unplaced.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005764; C:lysosome; ISS:UniProtKB.
DR GO; GO:0030883; F:endogenous lipid antigen binding; IBA:GO_Central.
DR GO; GO:0030884; F:exogenous lipid antigen binding; ISS:UniProtKB.
DR GO; GO:0030882; F:lipid antigen binding; ISS:UniProtKB.
DR GO; GO:0071723; F:lipopeptide binding; IBA:GO_Central.
DR GO; GO:0048006; P:antigen processing and presentation, endogenous lipid antigen via MHC class Ib; ISS:UniProtKB.
DR GO; GO:0048007; P:antigen processing and presentation, exogenous lipid antigen via MHC class Ib; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 3.30.500.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011161; MHC_I-like_Ag-recog.
DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF16497; MHC_I_3; 1.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR SUPFAM; SSF54452; SSF54452; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 3: Inferred from homology;
KW Cell membrane; Endoplasmic reticulum; Endosome; Glycoprotein; Immunity;
KW Immunoglobulin domain; Innate immunity; Lysosome; Membrane;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..335
FT /note="Antigen-presenting glycoprotein CD1d"
FT /id="PRO_0000042220"
FT TOPO_DOM 20..301
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 302..322
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 323..335
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 185..292
FT /note="Ig-like"
FT MOTIF 331..334
FT /note="Internalization signal"
FT /evidence="ECO:0000250"
FT BINDING 98
FT /ligand="a D-galactosylceramide"
FT /ligand_id="ChEBI:CHEBI:36498"
FT /evidence="ECO:0000250|UniProtKB:P15813"
FT BINDING 169..172
FT /ligand="a D-galactosylceramide"
FT /ligand_id="ChEBI:CHEBI:36498"
FT /evidence="ECO:0000250|UniProtKB:P15813"
FT BINDING 169
FT /ligand="a D-galactosylceramide"
FT /ligand_id="ChEBI:CHEBI:36498"
FT /evidence="ECO:0000250"
FT BINDING 172
FT /ligand="a D-galactosylceramide"
FT /ligand_id="ChEBI:CHEBI:36498"
FT /evidence="ECO:0000250"
FT CARBOHYD 38
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 60
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 126
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 181
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 335 AA; 37758 MW; 2F90B2741110001D CRC64;
MGCLLFLLLW ALLQAWGSAE VPQRLFPLRC LQISSFANSS WTRTDGLAWL GELQTHSWSN
DSDTVRSLKP WSQGTFSDQQ WETLQHIFRV YRSSFTRDVK EFAKMLRLSY PLELQVSAGC
EVHPGNASNN FFHVAFQGKD ILSFQGTSWE PTQEAPLWVN LAIQVLNQDK WTRETVQWLL
NGTCPQFVSG LLESGKSELE KQVKPKAWLS RGPSPGPGRL LLVCHVSGFY PKPVWVKWMR
GEQEQQDTQP GDILPNADET WYLRATLDVA AGEAAGLSCR VKHSSLEGQD IILYWGGSYT
SVGLIVLAVL ACLLFLLIVG FTSRFKRQTS YQGVL
