CD205_ARATH
ID CD205_ARATH Reviewed; 450 AA.
AC Q3E906;
DT 18-SEP-2013, integrated into UniProtKB/Swiss-Prot.
DT 31-JAN-2018, sequence version 3.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Cell division cycle 20.5, cofactor of APC complex;
DE Short=AtCDC20.5;
GN Name=CDC20-5; Synonyms=CDC20_5; OrderedLocusNames=At5g27570;
GN ORFNames=F15A18.30;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP REVIEW.
RX PubMed=12597875; DOI=10.1016/s1360-1385(02)00028-6;
RA Capron A., Okresz L., Genschik P.;
RT "First glance at the plant APC/C, a highly conserved ubiquitin-protein
RT ligase.";
RL Trends Plant Sci. 8:83-89(2003).
RN [4]
RP REVIEW, AND GENE FAMILY.
RX PubMed=21087491; DOI=10.1186/1471-2229-10-254;
RA Lima M.D.F., Eloy N.B., Pegoraro C., Sagit R., Rojas C., Bretz T.,
RA Vargas L., Elofsson A., de Oliveira A.C., Hemerly A.S., Ferreira P.C.G.;
RT "Genomic evolution and complexity of the Anaphase-promoting Complex (APC)
RT in land plants.";
RL BMC Plant Biol. 10:254-254(2010).
RN [5]
RP INTERACTION WITH GIG1 AND PYM.
RX PubMed=22167058; DOI=10.1105/tpc.111.092049;
RA Iwata E., Ikeda S., Matsunaga S., Kurata M., Yoshioka Y., Criqui M.-C.,
RA Genschik P., Ito M.;
RT "GIGAS CELL1, a novel negative regulator of the anaphase-promoting
RT complex/cyclosome, is required for proper mitotic progression and cell fate
RT determination in Arabidopsis.";
RL Plant Cell 23:4382-4393(2011).
RN [6]
RP SUBCELLULAR LOCATION, AND INTERACTION WITH MAD2 AND BUB1.
RX PubMed=21687678; DOI=10.1371/journal.pone.0020618;
RA Kevei Z., Baloban M., Da Ines O., Tiricz H., Kroll A., Regulski K.,
RA Mergaert P., Kondorosi E.;
RT "Conserved CDC20 cell cycle functions are carried out by two of the five
RT isoforms in Arabidopsis thaliana.";
RL PLoS ONE 6:E20618-E20618(2011).
CC -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex
CC that controls progression through mitosis and the G1 phase of the cell
CC cycle. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: The APC/C is composed of at least 11 subunits that stay
CC tightly associated throughout the cell cycle (By similarity). Binds to
CC GIG1 and PYM. Part of the mitotic checkpoint complex (MCC); interacts
CC with MAD2 and BUB1. {ECO:0000250, ECO:0000269|PubMed:21687678,
CC ECO:0000269|PubMed:22167058}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21687678}.
CC -!- SIMILARITY: Belongs to the WD repeat CDC20/Fizzy family. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Arabidopsis APC/C subunits;
CC URL="http://personal.rhul.ac.uk/ujba/110/apc/APC.htm";
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DR EMBL; AC007478; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002688; AED93702.2; -; Genomic_DNA.
DR RefSeq; NP_198109.2; NM_122639.2.
DR AlphaFoldDB; Q3E906; -.
DR SMR; Q3E906; -.
DR ELM; Q3E906; -.
DR IntAct; Q3E906; 1.
DR STRING; 3702.AT5G27570.1; -.
DR PaxDb; Q3E906; -.
DR PRIDE; Q3E906; -.
DR EnsemblPlants; AT5G27570.1; AT5G27570.1; AT5G27570.
DR GeneID; 832817; -.
DR Gramene; AT5G27570.1; AT5G27570.1; AT5G27570.
DR KEGG; ath:AT5G27570; -.
DR Araport; AT5G27570; -.
DR TAIR; locus:2143636; AT5G27570.
DR eggNOG; KOG0305; Eukaryota.
DR HOGENOM; CLU_014831_6_1_1; -.
DR InParanoid; Q3E906; -.
DR OMA; GCASSWP; -.
DR OrthoDB; 1220675at2759; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q3E906; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q3E906; baseline and differential.
DR Genevisible; Q3E906; AT.
DR GO; GO:0005680; C:anaphase-promoting complex; IBA:GO_Central.
DR GO; GO:0080008; C:Cul4-RING E3 ubiquitin ligase complex; ISS:TAIR.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0010997; F:anaphase-promoting complex binding; IBA:GO_Central.
DR GO; GO:0019900; F:kinase binding; IPI:UniProtKB.
DR GO; GO:1990757; F:ubiquitin ligase activator activity; IBA:GO_Central.
DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:1905786; P:positive regulation of anaphase-promoting complex-dependent catabolic process; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR024977; Apc4_WD40_dom.
DR InterPro; IPR033010; Cdc20/Fizzy.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR19918; PTHR19918; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Mitosis; Nucleus; Reference proteome; Repeat;
KW Ubl conjugation pathway; WD repeat.
FT CHAIN 1..450
FT /note="Cell division cycle 20.5, cofactor of APC complex"
FT /id="PRO_0000423310"
FT REPEAT 129..166
FT /note="WD 1"
FT REPEAT 171..210
FT /note="WD 2"
FT REPEAT 214..251
FT /note="WD 3"
FT REPEAT 255..294
FT /note="WD 4"
FT REPEAT 304..346
FT /note="WD 5"
FT REPEAT 348..389
FT /note="WD 6"
FT REPEAT 392..431
FT /note="WD 7"
SQ SEQUENCE 450 AA; 50099 MW; 76B8B9B59CD17F7F CRC64;
MMNTSSHLKA QASCPLVEHF LRRKLSKENF DRFIPNRSAM DFDFANYALT QGRKRNVDEV
TSASRKAYMT QLAEAMNQNR TRILAFRNKP KALLSSNHSD PPHQQPISVK PRRYIPQNSE
RVLDAPGIAD DFYLNLLDWG SSNVLAIALG DTVYLWDASS GSTYKLVTID EEEGPVTSIN
WTQDGLDLAI GLDNSEVQLW DCVSNRQVRT LRGGHESRVG SLAWNNHILT TGGMDGKIVN
NDVRIRSSIV ETYLGHTEEV CGLKWSESGK KLASGGNDNV VHIWDHRSVA SSNPTRQWLH
RFEEHTAAVR ALAWCPFQAS LLATGGGVGD GKIKFWNTHT GACLNSVETG SQVCSLLWSK
SERELLSSHG FTQNQLTLWK YPSMVKMAEL NGHTSRVLFM AQSPDGCTVA SAAGDETLRL
WNVFGEPPKT TKKAASKKYT DPFAHVNHIR
