CD20B_HUMAN
ID CD20B_HUMAN Reviewed; 519 AA.
AC Q86Y33; B7WNV8; B9EGL8; C9J6X8; C9JHE9; C9JKL5; Q86Y31; Q86Y32; Q8IUZ8;
AC Q8N1S1; Q8NG56;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-AUG-2010, sequence version 3.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Cell division cycle protein 20 homolog B;
GN Name=CDC20B; ORFNames=G6VTS76519;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), AND VARIANTS CYS-121;
RP ALA-496 AND TRP-503.
RA Hayashi A., Saito T.;
RT "CDC20-like protein.";
RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANTS CYS-121
RP AND ALA-496.
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANTS CYS-121 AND
RP ALA-496.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 5), AND VARIANTS
RP CYS-121; ALA-496 AND TRP-503.
RC TISSUE=Lung, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q86Y33; Q2TAC2: CCDC57; NbExp=3; IntAct=EBI-10260504, EBI-2808286;
CC Q86Y33; Q08379: GOLGA2; NbExp=3; IntAct=EBI-10260504, EBI-618309;
CC Q86Y33; Q15323: KRT31; NbExp=3; IntAct=EBI-10260504, EBI-948001;
CC Q86Y33; Q6A162: KRT40; NbExp=3; IntAct=EBI-10260504, EBI-10171697;
CC Q86Y33; P43364-2: MAGEA11; NbExp=3; IntAct=EBI-10260504, EBI-10178634;
CC Q86Y33; Q5JR59: MTUS2; NbExp=3; IntAct=EBI-10260504, EBI-742948;
CC Q86Y33; Q9NYY3: PLK2; NbExp=3; IntAct=EBI-10260504, EBI-721354;
CC Q86Y33; Q96R06: SPAG5; NbExp=3; IntAct=EBI-10260504, EBI-413317;
CC Q86Y33; Q12933: TRAF2; NbExp=3; IntAct=EBI-10260504, EBI-355744;
CC Q86Y33; P36406: TRIM23; NbExp=3; IntAct=EBI-10260504, EBI-740098;
CC Q86Y33; P14373: TRIM27; NbExp=3; IntAct=EBI-10260504, EBI-719493;
CC Q86Y33; O94972: TRIM37; NbExp=3; IntAct=EBI-10260504, EBI-741602;
CC Q86Y33-5; Q9H2G9: BLZF1; NbExp=5; IntAct=EBI-11983537, EBI-2548012;
CC Q86Y33-5; Q5TD97: FHL5; NbExp=3; IntAct=EBI-11983537, EBI-750641;
CC Q86Y33-5; P57678: GEMIN4; NbExp=3; IntAct=EBI-11983537, EBI-356700;
CC Q86Y33-5; O76003: GLRX3; NbExp=3; IntAct=EBI-11983537, EBI-374781;
CC Q86Y33-5; Q08379: GOLGA2; NbExp=3; IntAct=EBI-11983537, EBI-618309;
CC Q86Y33-5; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-11983537, EBI-2556193;
CC Q86Y33-5; O76011: KRT34; NbExp=3; IntAct=EBI-11983537, EBI-1047093;
CC Q86Y33-5; Q99750: MDFI; NbExp=3; IntAct=EBI-11983537, EBI-724076;
CC Q86Y33-5; Q9H8W4: PLEKHF2; NbExp=3; IntAct=EBI-11983537, EBI-742388;
CC Q86Y33-5; Q9Y6A5: TACC3; NbExp=3; IntAct=EBI-11983537, EBI-2554984;
CC Q86Y33-5; Q99081-3: TCF12; NbExp=3; IntAct=EBI-11983537, EBI-11952764;
CC Q86Y33-5; Q12933: TRAF2; NbExp=3; IntAct=EBI-11983537, EBI-355744;
CC Q86Y33-5; P14373: TRIM27; NbExp=3; IntAct=EBI-11983537, EBI-719493;
CC Q86Y33-5; O94972: TRIM37; NbExp=3; IntAct=EBI-11983537, EBI-741602;
CC Q86Y33-5; Q8N1B4: VPS52; NbExp=3; IntAct=EBI-11983537, EBI-2799833;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q86Y33-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q86Y33-2; Sequence=VSP_034095;
CC Name=3;
CC IsoId=Q86Y33-3; Sequence=VSP_034094;
CC Name=4;
CC IsoId=Q86Y33-4; Sequence=VSP_034092, VSP_034093;
CC Name=5;
CC IsoId=Q86Y33-5; Sequence=VSP_034089, VSP_034090, VSP_034091;
CC -!- SIMILARITY: Belongs to the WD repeat CDC20/Fizzy family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB97393.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB077043; BAC67701.1; -; mRNA.
DR EMBL; AB077044; BAB97393.1; ALT_INIT; mRNA.
DR EMBL; AB081750; BAC67702.1; -; mRNA.
DR EMBL; AB086378; BAC67705.1; -; mRNA.
DR EMBL; AK095246; BAC04508.1; -; mRNA.
DR EMBL; AC091977; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471123; EAW54901.1; -; Genomic_DNA.
DR EMBL; BC037547; AAH37547.1; -; mRNA.
DR EMBL; BC136572; AAI36573.1; -; mRNA.
DR CCDS; CCDS3966.1; -. [Q86Y33-2]
DR CCDS; CCDS47207.1; -. [Q86Y33-3]
DR CCDS; CCDS54852.1; -. [Q86Y33-1]
DR RefSeq; NP_001139206.2; NM_001145734.2. [Q86Y33-3]
DR RefSeq; NP_001163873.1; NM_001170402.1. [Q86Y33-1]
DR RefSeq; NP_689836.2; NM_152623.2. [Q86Y33-2]
DR AlphaFoldDB; Q86Y33; -.
DR SMR; Q86Y33; -.
DR BioGRID; 127940; 33.
DR IntAct; Q86Y33; 29.
DR STRING; 9606.ENSP00000370781; -.
DR GlyGen; Q86Y33; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q86Y33; -.
DR PhosphoSitePlus; Q86Y33; -.
DR BioMuta; CDC20B; -.
DR DMDM; 302393826; -.
DR jPOST; Q86Y33; -.
DR MassIVE; Q86Y33; -.
DR PaxDb; Q86Y33; -.
DR PeptideAtlas; Q86Y33; -.
DR PRIDE; Q86Y33; -.
DR ProteomicsDB; 70361; -. [Q86Y33-1]
DR ProteomicsDB; 70362; -. [Q86Y33-2]
DR ProteomicsDB; 70363; -. [Q86Y33-3]
DR ProteomicsDB; 70364; -. [Q86Y33-4]
DR ProteomicsDB; 70365; -. [Q86Y33-5]
DR Antibodypedia; 23375; 139 antibodies from 20 providers.
DR DNASU; 166979; -.
DR Ensembl; ENST00000296733.5; ENSP00000296733.1; ENSG00000164287.13. [Q86Y33-2]
DR Ensembl; ENST00000322374.10; ENSP00000315720.6; ENSG00000164287.13. [Q86Y33-3]
DR Ensembl; ENST00000381375.7; ENSP00000370781.2; ENSG00000164287.13. [Q86Y33-1]
DR Ensembl; ENST00000507931.1; ENSP00000423919.1; ENSG00000164287.13. [Q86Y33-5]
DR Ensembl; ENST00000513180.5; ENSP00000426776.1; ENSG00000164287.13. [Q86Y33-4]
DR GeneID; 166979; -.
DR KEGG; hsa:166979; -.
DR MANE-Select; ENST00000381375.7; ENSP00000370781.2; NM_001170402.1; NP_001163873.1.
DR UCSC; uc003jpn.3; human. [Q86Y33-1]
DR CTD; 166979; -.
DR DisGeNET; 166979; -.
DR GeneCards; CDC20B; -.
DR HGNC; HGNC:24222; CDC20B.
DR HPA; ENSG00000164287; Tissue enhanced (fallopian tube, kidney, testis).
DR neXtProt; NX_Q86Y33; -.
DR OpenTargets; ENSG00000164287; -.
DR PharmGKB; PA145149217; -.
DR VEuPathDB; HostDB:ENSG00000164287; -.
DR eggNOG; KOG0305; Eukaryota.
DR GeneTree; ENSGT00950000183104; -.
DR HOGENOM; CLU_014831_6_2_1; -.
DR InParanoid; Q86Y33; -.
DR OMA; IDWCPWQ; -.
DR OrthoDB; 1220675at2759; -.
DR PhylomeDB; Q86Y33; -.
DR TreeFam; TF337979; -.
DR PathwayCommons; Q86Y33; -.
DR SignaLink; Q86Y33; -.
DR BioGRID-ORCS; 166979; 10 hits in 1061 CRISPR screens.
DR ChiTaRS; CDC20B; human.
DR GenomeRNAi; 166979; -.
DR Pharos; Q86Y33; Tbio.
DR PRO; PR:Q86Y33; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q86Y33; protein.
DR Bgee; ENSG00000164287; Expressed in secondary oocyte and 31 other tissues.
DR Genevisible; Q86Y33; HS.
DR GO; GO:0005680; C:anaphase-promoting complex; IBA:GO_Central.
DR GO; GO:0010997; F:anaphase-promoting complex binding; IBA:GO_Central.
DR GO; GO:1990757; F:ubiquitin ligase activator activity; IBA:GO_Central.
DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IBA:GO_Central.
DR GO; GO:1905786; P:positive regulation of anaphase-promoting complex-dependent catabolic process; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR033010; Cdc20/Fizzy.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR19918; PTHR19918; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..519
FT /note="Cell division cycle protein 20 homolog B"
FT /id="PRO_0000339110"
FT REPEAT 229..266
FT /note="WD 1"
FT REPEAT 271..310
FT /note="WD 2"
FT REPEAT 311..341
FT /note="WD 3"
FT REPEAT 353..392
FT /note="WD 4"
FT REPEAT 399..441
FT /note="WD 5"
FT REPEAT 443..484
FT /note="WD 6"
FT REPEAT 487..519
FT /note="WD 7"
FT REGION 79..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 22..42
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034089"
FT VAR_SEQ 194..213
FT /note="GCKDGVRDESFHLKSSGDIN -> DHFSGSMKKRFEQEDVGGKD (in
FT isoform 5)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034090"
FT VAR_SEQ 214..519
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034091"
FT VAR_SEQ 330..372
FT /note="SGSRLGRVYHHDVRVAQHHVGTLRHKQAVCALKWSPDGRLLSS -> RLEFS
FT GVISAHCNLHLPSSWDYRRPPPCLVGQDWGVFIITMFG (in isoform 4)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_034092"
FT VAR_SEQ 373..519
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_034093"
FT VAR_SEQ 406..447
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_034094"
FT VAR_SEQ 483..486
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039, ECO:0000303|Ref.1"
FT /id="VSP_034095"
FT VARIANT 8
FT /note="T -> P (in dbSNP:rs173042)"
FT /id="VAR_043860"
FT VARIANT 17
FT /note="E -> K (in dbSNP:rs423074)"
FT /id="VAR_043861"
FT VARIANT 97
FT /note="T -> S (in dbSNP:rs34132993)"
FT /id="VAR_043862"
FT VARIANT 121
FT /note="R -> C (in dbSNP:rs1021580)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1,
FT ECO:0000269|Ref.4"
FT /id="VAR_043863"
FT VARIANT 496
FT /note="S -> A (in dbSNP:rs3104230)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1,
FT ECO:0000269|Ref.4"
FT /id="VAR_043864"
FT VARIANT 503
FT /note="R -> W (in dbSNP:rs444527)"
FT /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1"
FT /id="VAR_043865"
SQ SEQUENCE 519 AA; 57335 MW; 2D40A57A4363A349 CRC64;
MEWKLERTAP RRVRTEEEML WESIMRVLSK DLKQKRSQDS ANVLDSVNAT YSDFKSNFAK
RLSAEVPVAS SPITTRWQQS QTRALSSDSF GEEQSTTYLP EASGSVLKTP PEKETLTLGS
RKEQLKTPSK GISETSNSAL HFCKAPHAMD RDWKESVASK GQKCLKQLFV TQNVVQQANG
KMQLCEQSEC VWKGCKDGVR DESFHLKSSG DINDSILQPE VKIHITGLRN DYYLNILDWS
FQNLVAIALG SAVYIWNGEN HNGIENIDLS LTCNYISSVS WIKEGTCLAV GTSEGEVQLW
DVVTKKRLRN MLGHLSVVGA LSWNHFILSS GSRLGRVYHH DVRVAQHHVG TLRHKQAVCA
LKWSPDGRLL SSGCSDGLLT IWPHDPGASA QGQPLKVITQ STAVKAMDWC PWQSGVLAIG
GGMKDGRLHI LDINAGKSIQ TPSTNSQICS LIWLPKTKEI ATGQGTPKND VTVWTCPTVS
RSGGFFGHRG RVLHLSLSPD QTRVFSAAAD GTASVWNCY
