CD24_RAT
ID CD24_RAT Reviewed; 76 AA.
AC Q07490; Q0P5T1;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Signal transducer CD24;
DE AltName: Full=Heat-stable antigen;
DE Short=HSA;
DE AltName: Full=Nectadrin;
DE AltName: CD_antigen=CD24;
DE Flags: Precursor;
GN Name=Cd24; Synonyms=Cd24a;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Wistar; TISSUE=Embryonic brain;
RX PubMed=8292828; DOI=10.1002/aja.1001980102;
RA Shirasawa T., Akashi T., Sakamoto K., Takahashi H., Maruyama N.,
RA Hirokawa K.;
RT "Gene expression of CD24 core peptide molecule in developing brain and
RT developing non-neural tissues.";
RL Dev. Dyn. 198:1-13(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Fischer;
RX PubMed=9004038; DOI=10.1242/jcs.109.13.3035;
RA Magnaldo T.A., Barrandon Y.;
RT "CD24 (heat stable antigen, nectadrin), a novel keratinocyte
RT differentiation marker, is preferentially expressed in areas of the hair
RT follicle containing the colony-forming cells.";
RL J. Cell Sci. 109:3035-3045(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney, and Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May have a pivotal role in cell differentiation of different
CC cell types. Signaling could be triggered by the binding of a lectin-
CC like ligand to the CD24 carbohydrates, and transduced by the release of
CC second messengers derived from the GPI-anchor. Modulates B-cell
CC activation responses. In association with SIGLEC10 may be involved in
CC the selective suppression of the immune response to danger-associated
CC molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role
CC in the control of autoimmunity (By similarity).
CC {ECO:0000250|UniProtKB:P24807, ECO:0000250|UniProtKB:P25063}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
CC -!- TISSUE SPECIFICITY: Expressed in the central nervous system, in
CC postmitotic cells of spinal cord, hindbrain, midbrain and forebrain.
CC Expressed in epithelium during the development of non-neural tissues.
CC Expressed in tooth development, specifically in mesenchymal cells
CC differentiating into odontoblast in dental papilla, as well as in the
CC developing eye and hair follicle.
CC -!- DEVELOPMENTAL STAGE: Detected in primitive ectoderm, mesoderm and
CC ventral endoderm; down-regulated when organogenesis is completed.
CC -!- PTM: Extensively O-glycosylated (By similarity). The carbohydrate
CC structure may be regulated in a tissue-specific and developmental
CC stage-specific manner. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CD24 family. {ECO:0000305}.
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DR EMBL; Z11663; CAA77731.1; -; mRNA.
DR EMBL; U49062; AAA91470.1; -; mRNA.
DR EMBL; BC064439; AAH64439.1; -; mRNA.
DR EMBL; BC081851; AAH81851.1; -; mRNA.
DR PIR; I53107; I53107.
DR RefSeq; NP_036884.1; NM_012752.3.
DR AlphaFoldDB; Q07490; -.
DR STRING; 10116.ENSRNOP00000000352; -.
DR GlyGen; Q07490; 3 sites.
DR PaxDb; Q07490; -.
DR GeneID; 25145; -.
DR KEGG; rno:25145; -.
DR UCSC; RGD:2298; rat.
DR CTD; 100133941; -.
DR RGD; 2298; Cd24.
DR VEuPathDB; HostDB:ENSRNOG00000000321; -.
DR eggNOG; ENOG502RVSX; Eukaryota.
DR HOGENOM; CLU_198463_1_0_1; -.
DR InParanoid; Q07490; -.
DR OMA; PQNTWTA; -.
DR OrthoDB; 1640445at2759; -.
DR PhylomeDB; Q07490; -.
DR TreeFam; TF338512; -.
DR PRO; PR:Q07490; -.
DR Proteomes; UP000002494; Chromosome 20.
DR Bgee; ENSRNOG00000000321; Expressed in colon and 20 other tissues.
DR Genevisible; Q07490; RN.
DR GO; GO:0031362; C:anchored component of external side of plasma membrane; IDA:MGI.
DR GO; GO:0046658; C:anchored component of plasma membrane; TAS:RGD.
DR GO; GO:0009986; C:cell surface; ISS:UniProtKB.
DR GO; GO:0060170; C:ciliary membrane; ISO:RGD.
DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
DR GO; GO:0016020; C:membrane; ISS:UniProtKB.
DR GO; GO:0045121; C:membrane raft; ISS:UniProtKB.
DR GO; GO:0031528; C:microvillus membrane; ISO:RGD.
DR GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:0030246; F:carbohydrate binding; ISO:RGD.
DR GO; GO:0030544; F:Hsp70 protein binding; ISO:RGD.
DR GO; GO:0051879; F:Hsp90 protein binding; ISO:RGD.
DR GO; GO:0019901; F:protein kinase binding; ISS:UniProtKB.
DR GO; GO:0030296; F:protein tyrosine kinase activator activity; ISS:UniProtKB.
DR GO; GO:0008637; P:apoptotic mitochondrial changes; ISO:RGD.
DR GO; GO:0030262; P:apoptotic nuclear changes; ISO:RGD.
DR GO; GO:0097190; P:apoptotic signaling pathway; ISO:RGD.
DR GO; GO:0032597; P:B cell receptor transport into membrane raft; ISS:UniProtKB.
DR GO; GO:0001775; P:cell activation; ISS:UniProtKB.
DR GO; GO:0007155; P:cell adhesion; TAS:RGD.
DR GO; GO:0016477; P:cell migration; ISS:UniProtKB.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; ISO:RGD.
DR GO; GO:0098609; P:cell-cell adhesion; NAS:RGD.
DR GO; GO:0007267; P:cell-cell signaling; TAS:RGD.
DR GO; GO:0032600; P:chemokine receptor transport out of membrane raft; ISS:UniProtKB.
DR GO; GO:0042632; P:cholesterol homeostasis; ISS:UniProtKB.
DR GO; GO:0072139; P:glomerular parietal epithelial cell differentiation; ISS:UniProtKB.
DR GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; ISO:RGD.
DR GO; GO:0034109; P:homotypic cell-cell adhesion; ISO:RGD.
DR GO; GO:0006955; P:immune response; IEP:RGD.
DR GO; GO:0007159; P:leukocyte cell-cell adhesion; ISO:RGD.
DR GO; GO:0002523; P:leukocyte migration involved in inflammatory response; ISO:RGD.
DR GO; GO:0030889; P:negative regulation of B cell proliferation; ISO:RGD.
DR GO; GO:0034119; P:negative regulation of erythrocyte aggregation; ISO:RGD.
DR GO; GO:0034107; P:negative regulation of erythrocyte clearance; ISO:RGD.
DR GO; GO:0106015; P:negative regulation of inflammatory response to wounding; ISO:RGD.
DR GO; GO:0032715; P:negative regulation of interleukin-6 production; ISO:RGD.
DR GO; GO:0071638; P:negative regulation of monocyte chemotactic protein-1 production; ISO:RGD.
DR GO; GO:0007406; P:negative regulation of neuroblast proliferation; ISO:RGD.
DR GO; GO:0050768; P:negative regulation of neurogenesis; ISO:RGD.
DR GO; GO:0045665; P:negative regulation of neuron differentiation; ISO:RGD.
DR GO; GO:0046014; P:negative regulation of T cell homeostatic proliferation; ISO:RGD.
DR GO; GO:0032913; P:negative regulation of transforming growth factor beta3 production; ISS:UniProtKB.
DR GO; GO:0032720; P:negative regulation of tumor necrosis factor production; ISO:RGD.
DR GO; GO:0007274; P:neuromuscular synaptic transmission; ISO:RGD.
DR GO; GO:0031175; P:neuron projection development; ISO:RGD.
DR GO; GO:0072112; P:podocyte differentiation; ISS:UniProtKB.
DR GO; GO:0042104; P:positive regulation of activated T cell proliferation; ISS:UniProtKB.
DR GO; GO:0046641; P:positive regulation of alpha-beta T cell proliferation; ISO:RGD.
DR GO; GO:0002904; P:positive regulation of B cell apoptotic process; ISO:RGD.
DR GO; GO:0050850; P:positive regulation of calcium-mediated signaling; ISO:RGD.
DR GO; GO:0033630; P:positive regulation of cell adhesion mediated by integrin; ISO:RGD.
DR GO; GO:0022409; P:positive regulation of cell-cell adhesion; ISO:RGD.
DR GO; GO:0033634; P:positive regulation of cell-cell adhesion mediated by integrin; ISO:RGD.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISS:UniProtKB.
DR GO; GO:0002863; P:positive regulation of inflammatory response to antigenic stimulus; ISO:RGD.
DR GO; GO:0106016; P:positive regulation of inflammatory response to wounding; ISO:RGD.
DR GO; GO:0033625; P:positive regulation of integrin activation; ISO:RGD.
DR GO; GO:0043406; P:positive regulation of MAP kinase activity; ISS:UniProtKB.
DR GO; GO:2000768; P:positive regulation of nephron tubule epithelial cell differentiation; ISS:UniProtKB.
DR GO; GO:0010976; P:positive regulation of neuron projection development; ISO:RGD.
DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISO:RGD.
DR GO; GO:0042103; P:positive regulation of T cell homeostatic proliferation; ISO:RGD.
DR GO; GO:0002842; P:positive regulation of T cell mediated immune response to tumor cell; ISO:RGD.
DR GO; GO:0002329; P:pre-B cell differentiation; ISO:RGD.
DR GO; GO:0045577; P:regulation of B cell differentiation; ISO:RGD.
DR GO; GO:0022407; P:regulation of cell-cell adhesion; ISO:RGD.
DR GO; GO:0033632; P:regulation of cell-cell adhesion mediated by integrin; ISO:RGD.
DR GO; GO:0001959; P:regulation of cytokine-mediated signaling pathway; ISS:UniProtKB.
DR GO; GO:0043408; P:regulation of MAPK cascade; ISS:UniProtKB.
DR GO; GO:0042325; P:regulation of phosphorylation; ISS:UniProtKB.
DR GO; GO:0045730; P:respiratory burst; ISS:UniProtKB.
DR GO; GO:0043627; P:response to estrogen; ISS:UniProtKB.
DR GO; GO:0001666; P:response to hypoxia; ISS:UniProtKB.
DR GO; GO:0002237; P:response to molecule of bacterial origin; ISS:UniProtKB.
DR GO; GO:0048488; P:synaptic vesicle endocytosis; ISO:RGD.
DR GO; GO:0031295; P:T cell costimulation; ISS:UniProtKB.
DR InterPro; IPR028029; CD24.
DR PANTHER; PTHR16676; PTHR16676; 1.
DR Pfam; PF14984; CD24; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Developmental protein; Differentiation; Glycoprotein;
KW GPI-anchor; Lipoprotein; Membrane; Reference proteome; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT PEPTIDE 27..56
FT /note="Signal transducer CD24"
FT /id="PRO_0000020897"
FT PROPEP 57..76
FT /note="Removed in mature form"
FT /evidence="ECO:0000250"
FT /id="PRO_0000020898"
FT LIPID 56
FT /note="GPI-anchor amidated serine"
FT /evidence="ECO:0000255"
FT CARBOHYD 27
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 37
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 48
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 76 AA; 7862 MW; 42846E70EC39D958 CRC64;
MGRAMVVRLG LGLLLLALLL PTQIYCNQTS VAPFSGNQSI SAAPNPTNAT TRSGCSSLQS
TAGLLALSLS LLHLYC
