CD276_RAT
ID CD276_RAT Reviewed; 316 AA.
AC Q7TPB4;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=CD276 antigen;
DE AltName: Full=B7 homolog 3;
DE Short=B7-H3;
DE AltName: Full=Costimulatory molecule;
DE AltName: CD_antigen=CD276;
DE Flags: Precursor;
GN Name=Cd276; Synonyms=B7h3;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12925852; DOI=10.1038/ni967;
RA Suh W.-K., Gajewska B.U., Okada H., Gronski M.A., Bertram E.M., Dawicki W.,
RA Duncan G.S., Bukczynski J., Plyte S., Elia A., Wakeham A., Itie A.,
RA Chung S., Da Costa J., Arya S., Horan T., Campbell P., Gaida K.,
RA Ohashi P.S., Watts T.H., Yoshinaga S.K., Bray M.R., Jordana M., Mak T.W.;
RT "The B7 family member B7-H3 preferentially down-regulates T helper type 1-
RT mediated immune responses.";
RL Nat. Immunol. 4:899-906(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Modulates T-cell-mediated immune responses and the
CC development of acute and chronic transplant rejection. May play a
CC positive regulatory role in bone formation and has a dual role in the
CC bone-immune interface. Induces antitumor immunity as it activates both
CC acquired and innate immunity leading to natural killer cell and CD8 T-
CC cell dependent killing of tumor cells (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with TREML2 and this interaction enhances T-cell
CC activation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. BTN/MOG family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY190319; AAP04008.1; -; mRNA.
DR EMBL; BC100064; AAI00065.1; -; mRNA.
DR RefSeq; NP_877976.1; NM_182824.2.
DR AlphaFoldDB; Q7TPB4; -.
DR SMR; Q7TPB4; -.
DR BioGRID; 261125; 1.
DR STRING; 10116.ENSRNOP00000049249; -.
DR GlyGen; Q7TPB4; 3 sites.
DR SwissPalm; Q7TPB4; -.
DR jPOST; Q7TPB4; -.
DR PaxDb; Q7TPB4; -.
DR PRIDE; Q7TPB4; -.
DR GeneID; 315716; -.
DR KEGG; rno:315716; -.
DR UCSC; RGD:727815; rat.
DR CTD; 80381; -.
DR RGD; 727815; Cd276.
DR VEuPathDB; HostDB:ENSRNOG00000033608; -.
DR eggNOG; ENOG502QU94; Eukaryota.
DR HOGENOM; CLU_013137_8_1_1; -.
DR InParanoid; Q7TPB4; -.
DR OMA; AQLSLIW; -.
DR OrthoDB; 1254753at2759; -.
DR PhylomeDB; Q7TPB4; -.
DR TreeFam; TF331083; -.
DR PRO; PR:Q7TPB4; -.
DR Proteomes; UP000002494; Chromosome 8.
DR Bgee; ENSRNOG00000033608; Expressed in ovary and 19 other tissues.
DR Genevisible; Q7TPB4; RN.
DR GO; GO:0009897; C:external side of plasma membrane; ISO:RGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR GO; GO:0005102; F:signaling receptor binding; ISO:RGD.
DR GO; GO:0050728; P:negative regulation of inflammatory response; ISO:RGD.
DR GO; GO:0032689; P:negative regulation of interferon-gamma production; ISO:RGD.
DR GO; GO:0032703; P:negative regulation of interleukin-2 production; ISO:RGD.
DR GO; GO:0042130; P:negative regulation of T cell proliferation; ISO:RGD.
DR GO; GO:0030501; P:positive regulation of bone mineralization; ISO:RGD.
DR GO; GO:0032729; P:positive regulation of interferon-gamma production; ISO:RGD.
DR GO; GO:0032743; P:positive regulation of interleukin-2 production; ISO:RGD.
DR GO; GO:0045669; P:positive regulation of osteoblast differentiation; ISO:RGD.
DR GO; GO:0042102; P:positive regulation of T cell proliferation; ISO:RGD.
DR GO; GO:0001817; P:regulation of cytokine production; IBA:GO_Central.
DR GO; GO:0050776; P:regulation of immune response; ISO:RGD.
DR GO; GO:0042110; P:T cell activation; ISO:RGD.
DR GO; GO:0050852; P:T cell receptor signaling pathway; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; SSF48726; 2.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..316
FT /note="CD276 antigen"
FT /id="PRO_0000045803"
FT TOPO_DOM 29..248
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 270..316
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 29..139
FT /note="Ig-like V-type"
FT DOMAIN 145..238
FT /note="Ig-like C2-type"
FT REGION 281..316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..316
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 104
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 189
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 215
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 165..220
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 316 AA; 34075 MW; 80FB9D68D0A4143B CRC64;
MLRGWGGPSV GVSMGTALGV LCLCLTGAVE VQVSEDPVVA LVDTDATLRC SFSPEPGFSL
RQLNLIWQLT DTKQLVHSFT EGRDQGSAYA NRTALFPDLL VQGNASLRLQ RVRVTDEGSY
TCFVSIQDFD SAAVSLQVAA PYSKPSMTLE PNKDLRPGDM VTITCSSYQG YPEAEVFWKD
GQGLPLTGNV TTSQMANERG LFDVHSVLRV VLGANGTYSC LVRNPVLQQD AHGSVTITGQ
PMTFPPEALW VTVGLSVCLV ILLVALAFVC WRKIKQSCEE ENAGAEDQDG DGEGSKTALR
PLKHSENKED DGQEIA
