ID   CD276_XENLA             Reviewed;         308 AA.
AC   Q68EV1;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=CD276 antigen homolog;
DE   AltName: CD_antigen=CD276;
DE   Flags: Precursor;
GN   Name=cd276;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Modulates immune responses. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the immunoglobulin superfamily. BTN/MOG family.
CC       {ECO:0000305}.
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DR   EMBL; BC080099; AAH80099.1; -; mRNA.
DR   RefSeq; NP_001087555.1; NM_001094086.1.
DR   AlphaFoldDB; Q68EV1; -.
DR   SMR; Q68EV1; -.
DR   MEROPS; I43.001; -.
DR   DNASU; 447379; -.
DR   GeneID; 447379; -.
DR   KEGG; xla:447379; -.
DR   CTD; 447379; -.
DR   Xenbase; XB-GENE-921543; cd276.S.
DR   OrthoDB; 1254753at2759; -.
DR   Proteomes; UP000186698; Chromosome 3S.
DR   Bgee; 447379; Expressed in blastula and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR013162; CD80_C2-set.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF08205; C2-set_2; 1.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 2.
DR   SMART; SM00407; IGc1; 1.
DR   SMART; SM00408; IGc2; 2.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   PROSITE; PS50835; IG_LIKE; 2.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Immunoglobulin domain; Membrane; Reference proteome;
KW   Repeat; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255"
FT   CHAIN           16..308
FT                   /note="CD276 antigen homolog"
FT                   /id="PRO_0000045804"
FT   TOPO_DOM        16..236
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        258..308
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          21..125
FT                   /note="Ig-like V-type"
FT   DOMAIN          135..228
FT                   /note="Ig-like C2-type"
FT   REGION          270..308
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        270..287
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        37..112
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        155..210
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   308 AA;  34020 MW;  63814006E6CE4265 CRC64;
     MAALCLLLLL SLAEAIDLRV PELPVIGLLD KDVILPCWFT PSEGFTPKNL SVFWKLPNQQ
     QDYGFVLGED LQENQSPQYK DRISLFHEEL SKGNMSVLLQ QVRLTDEGIY TCFVNVQNSS
     SASVSLQVGA PFTKPTLHLE PSEALKPGDQ VTVTCHTYDG YPEANILWQN GEGQNMTENI
     TTSQVANEKG LFHVQSSLSV ILETSDTYTC LVFNPVLQDV THASLTVTGQ HLSFPPLVLW
     VTVGLSICLL CLLVALACVC RKHLKQTCEE EQENAGNEEH EENGELKTAM QPLKVTSPGE
     DDDAECLE