CD27_MOUSE
ID CD27_MOUSE Reviewed; 250 AA.
AC P41272;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 173.
DE RecName: Full=CD27 antigen;
DE AltName: Full=CD27L receptor;
DE AltName: Full=T-cell activation antigen CD27;
DE AltName: Full=Tumor necrosis factor receptor superfamily member 7;
DE AltName: CD_antigen=CD27;
DE Flags: Precursor;
GN Name=Cd27; Synonyms=Tnfrsf7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6 X CBA; TISSUE=Thymus;
RX PubMed=8384562; DOI=10.1002/eji.1830230427;
RA Gravestein L.A., Blom B., Nolten L.A., de Vries E., van der Horst G.,
RA Ossendorp F., Borst J., Loenen W.A.;
RT "Cloning and expression of murine CD27: comparison with 4-1BB, another
RT lymphocyte-specific member of the nerve growth factor receptor family.";
RL Eur. J. Immunol. 23:943-950(1993).
CC -!- FUNCTION: Receptor for CD70/CD27L. May play a role in survival of
CC activated T-cells. May play a role in apoptosis through association
CC with SIVA1.
CC -!- SUBUNIT: Homodimer. Interacts with SIVA1 and TRAF2 (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC -!- TISSUE SPECIFICITY: In thymus and spleen, but not in non-lymphoid
CC tissues.
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DR EMBL; L24495; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS39639.1; -.
DR PIR; A49053; A49053.
DR RefSeq; NP_001028298.1; NM_001033126.2.
DR AlphaFoldDB; P41272; -.
DR SMR; P41272; -.
DR BioGRID; 204252; 2.
DR IntAct; P41272; 1.
DR STRING; 10090.ENSMUSP00000032486; -.
DR GlyGen; P41272; 2 sites.
DR iPTMnet; P41272; -.
DR PhosphoSitePlus; P41272; -.
DR EPD; P41272; -.
DR PaxDb; P41272; -.
DR PRIDE; P41272; -.
DR ProteomicsDB; 283746; -.
DR Antibodypedia; 3716; 2002 antibodies from 50 providers.
DR DNASU; 21940; -.
DR Ensembl; ENSMUST00000032486; ENSMUSP00000032486; ENSMUSG00000030336.
DR GeneID; 21940; -.
DR KEGG; mmu:21940; -.
DR UCSC; uc009duc.1; mouse.
DR CTD; 939; -.
DR MGI; MGI:88326; Cd27.
DR VEuPathDB; HostDB:ENSMUSG00000030336; -.
DR eggNOG; ENOG502SBE3; Eukaryota.
DR GeneTree; ENSGT00510000049297; -.
DR InParanoid; P41272; -.
DR OMA; HGEAAQC; -.
DR OrthoDB; 1240949at2759; -.
DR PhylomeDB; P41272; -.
DR TreeFam; TF336960; -.
DR Reactome; R-MMU-5669034; TNFs bind their physiological receptors.
DR BioGRID-ORCS; 21940; 2 hits in 75 CRISPR screens.
DR ChiTaRS; Cd27; mouse.
DR PRO; PR:P41272; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; P41272; protein.
DR Bgee; ENSMUSG00000030336; Expressed in thymus and 77 other tissues.
DR ExpressionAtlas; P41272; baseline and differential.
DR Genevisible; P41272; MM.
DR GO; GO:0009986; C:cell surface; IDA:UniProtKB.
DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; ISO:MGI.
DR GO; GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; ISS:UniProtKB.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0042100; P:B cell proliferation; NAS:UniProtKB.
DR GO; GO:0097191; P:extrinsic apoptotic signaling pathway; ISO:MGI.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
DR GO; GO:0070233; P:negative regulation of T cell apoptotic process; IPI:MGI.
DR GO; GO:0045579; P:positive regulation of B cell differentiation; IEA:InterPro.
DR GO; GO:0002639; P:positive regulation of immunoglobulin production; NAS:UniProtKB.
DR GO; GO:0032729; P:positive regulation of interferon-gamma production; NAS:UniProtKB.
DR GO; GO:0046330; P:positive regulation of JNK cascade; IDA:UniProtKB.
DR GO; GO:0045582; P:positive regulation of T cell differentiation; NAS:UniProtKB.
DR CDD; cd13408; TNFRSF7; 1.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR022328; TNFR_7.
DR InterPro; IPR034000; TNFRSF7_N.
DR PRINTS; PR01960; TNFACTORR7.
DR SMART; SM00208; TNFR; 2.
DR PROSITE; PS00652; TNFR_NGFR_1; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; Disulfide bond; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..250
FT /note="CD27 antigen"
FT /id="PRO_0000034572"
FT TOPO_DOM 24..182
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 204..250
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 26..63
FT /note="TNFR-Cys 1"
FT REPEAT 64..104
FT /note="TNFR-Cys 2"
FT REPEAT 105..141
FT /note="TNFR-Cys 3"
FT REGION 128..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 209..250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..148
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 95
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 162
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 27..39
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 40..53
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 43..62
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 65..81
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 84..96
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 87..104
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 106..117
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 112..120
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 250 AA; 28164 MW; 48477C2E0C244697 CRC64;
MAWPPPYWLC MLGTLVGLSA TLAPNSCPDK HYWTGGGLCC RMCEPGTFFV KDCEQDRTAA
QCDPCIPGTS FSPDYHTRPH CESCRHCNSG FLIRNCTVTA NAECSCSKNW QCRDQECTEC
DPPLNPALTR QPSETPSPQP PPTHLPHGTE KPSWPLHRQL PNSTVYSQRS SHRPLCSSDC
IRIFVTFSSM FLIFVLGAIL FFHQRRNHGP NEDRQAVPEE PCPYSCPREE EGSAIPIQED
YRKPEPAFYP
