ID   CD28_CHICK              Reviewed;         221 AA.
AC   P31043;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   03-AUG-2022, entry version 140.
DE   RecName: Full=T-cell-specific surface glycoprotein CD28 homolog;
DE   AltName: Full=CHT28;
DE   Flags: Precursor;
GN   Name=CD28;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=White leghorn; TISSUE=Spleen;
RX   PubMed=8144954;
RA   Young J.R., Davison T.F., Tregaskes C.A., Rennie M.C., Vainio O.;
RT   "Monomeric homologue of mammalian CD28 is expressed on chicken T cells.";
RL   J. Immunol. 152:3848-3851(1994).
CC   -!- FUNCTION: Possibly involved in T-cell activation.
CC       {ECO:0000250|UniProtKB:P10747}.
CC   -!- SUBUNIT: Monomer.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
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DR   EMBL; X67915; CAA48114.1; -; mRNA.
DR   PIR; I50619; S25168.
DR   RefSeq; NP_990642.1; NM_205311.1.
DR   AlphaFoldDB; P31043; -.
DR   SMR; P31043; -.
DR   STRING; 9031.ENSGALP00000014099; -.
DR   PaxDb; P31043; -.
DR   GeneID; 396249; -.
DR   KEGG; gga:396249; -.
DR   CTD; 940; -.
DR   VEuPathDB; HostDB:geneid_396249; -.
DR   eggNOG; ENOG502SAVP; Eukaryota.
DR   HOGENOM; CLU_085095_1_0_1; -.
DR   InParanoid; P31043; -.
DR   OrthoDB; 1222373at2759; -.
DR   PhylomeDB; P31043; -.
DR   TreeFam; TF335679; -.
DR   PRO; PR:P31043; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0044214; C:spanning component of plasma membrane; ISS:AgBase.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0042102; P:positive regulation of T cell proliferation; IBA:GO_Central.
DR   GO; GO:0042110; P:T cell activation; IBA:GO_Central.
DR   GO; GO:0031295; P:T cell costimulation; IBA:GO_Central.
DR   GO; GO:0050852; P:T cell receptor signaling pathway; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR008093; CD28.
DR   InterPro; IPR040216; CTLA4/CD28.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013106; Ig_V-set.
DR   PANTHER; PTHR11494; PTHR11494; 1.
DR   Pfam; PF15910; V-set_2; 1.
DR   PRINTS; PR01717; CD28ANTIGEN.
DR   SUPFAM; SSF48726; SSF48726; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..13
FT                   /evidence="ECO:0000255"
FT   CHAIN           14..221
FT                   /note="T-cell-specific surface glycoprotein CD28 homolog"
FT                   /id="PRO_0000014656"
FT   TOPO_DOM        14..149
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        175..221
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          28..137
FT                   /note="Ig-like V-type"
FT   REGION          188..209
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        33
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        41
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        45
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        71
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        100
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        128
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        40..111
FT                   /evidence="ECO:0000250"
FT   DISULFID        66..85
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   221 AA;  25401 MW;  60245A3D493CF109 CRC64;
     MLGILVVLCL IPAADVTENK ILVAQRPLLI VANRTATLVC NYTYNGTGKE FRASLHKGTD
     SAVEVCFISW NMTKINSNSN KEFNCRGIHD KDKVIFNLWN MSASQTDIYF CKIEAMYPPP
     YVYNEKSNGT VIHVRETPIQ TQEPESATSY WVMVAVTGLL GFYSMLITAV FIIYRQKSKR
     NRYRQSDYMN MTPRHPPHQK NKGYPSYAPT RDYTAYRSWQ P